MICROSECOND RESPONSE ELECTROCHEMICAL SENSORS AND METHODS THEREOF
First Claim
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1. A system for the measurement of analyte concentration comprising:
- an electrochemical cell comprising a working electrode coated with a protein layer and a diffusion limiting barrier covering the protein layer, anda counter electrode;
a voltage source which provides a voltage between the working electrode and the counter electrode when electrically connected through a conductive medium; and
a computing system which measures the dynamic voltage output to the counter electrode within a time period prior to a response from the working electrode.
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Abstract
A system for the measurement of analyte concentration includes an electrochemical cell having a working electrode coated with a protein layer and a diffusion limiting barrier covering the protein layer, and a counter electrode; a voltage source which provides a voltage between the working electrode and the counter electrode when electrically connected by a conductive medium; and a computing system which measures the dynamic voltage output to the counter electrode within a time period prior to a response from the working electrode and method for use is disclosed.
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Citations
20 Claims
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1. A system for the measurement of analyte concentration comprising:
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an electrochemical cell comprising a working electrode coated with a protein layer and a diffusion limiting barrier covering the protein layer, and a counter electrode; a voltage source which provides a voltage between the working electrode and the counter electrode when electrically connected through a conductive medium; and a computing system which measures the dynamic voltage output to the counter electrode within a time period prior to a response from the working electrode. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
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15. An electronic circuit for measuring voltage or charge of a counter electrode within a time period prior to a working electrode response comprising a voltage waveform source between a counter and working electrode and an analog to digital converter capable of sampling the voltages at a rate sufficient to yield two or more voltage measurements within a time period between 0 and a time point defined by tVmax.
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16. A method for determining a concentration of at least one analyte, the method comprising:
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providing an electrochemical cell comprising a working electrode coated with a protein layer and a diffusion limiting barrier covering the protein layer, and a counter electrode;
a voltage source which provides a voltage between the working electrode and the counter electrode; and
a computing system which measures the dynamic voltage output to the counter electrode;positioning the working electrode and the counter electrode in an electrically conductive medium; applying voltage from the voltage source to the working electrode and the counter electrode; detecting the applied voltage to the counter electrode prior to the working electrode response; and determining a concentration of at least one analyte. - View Dependent Claims (17, 18, 19, 20)
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Specification