COATING OF DEVICES WITH EFFECTOR COMPOUNDS

• US 20100215708A1
• Filed: 06/28/2007
• Published: 08/26/2010
• Est. Priority Date: 06/29/2006
• Status: Abandoned Application

• Current Assignee: Andreas Zumbuehl, Danial S. Kohane, Gerald R. Fink, Lino Da Silva Ferreira, Robert S. Langer
• Original Assignee: Andreas Zumbuehl, Danial S. Kohane, Gerald R. Fink, Lino Da Silva Ferreira, Robert S. Langer
• Inventors: Da Silva Ferreira, Lino, Kohane, Danial S., Langer, Robert S., Zumbuehl, Andreas, Fink, Gerald R.
• Application Number:
  US12/306,794
• Publication Number:
  US 20100215708A1
• Time in Patent Office: Days
• US Class Current: 424/422
• CPC Class Codes: A61L 2300/404 Biocides, antimicrobial agents, antiseptic agents
• CPC Class Codes: A61L 2300/602 Type of release, e.g. controlled, sustained, slow
• CPC Class Codes: A61L 27/34 Macromolecular materials
• CPC Class Codes: A61L 27/54 Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence
• CPC Class Codes: A61P 31/00 Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics

Abstract

This invention is directed to substrates, materials and devices coated with a gel, foam, film, particle or composition comprising a polymei solvent and effector compounds attached thereto, processes of producing the same, and methods of use thereof, of in, inter-alia, biological applications, including preventing infection and the treatment of various diseases.

Claims

3-4. -4. (canceled)

6. (canceled)

8. (canceled)

14. (canceled)

16. (canceled)

18. (canceled)

23. (canceled)

26-34. -34. (canceled)

35. A process for preparing a coated material comprising an effector compound associated thereto, said process comprising the steps of:

a. preparing a gel or film comprising a polymer dispersed in a solvent;

b. loading said gel or film with an effector compound; and

c. attaching said gel or film in (b) to at least a portion of a surface of a substrate;

thereby preparing a coated material.

1. A coated material comprising:

a. a substrate;

b. a gel or film comprising a polymer, said gel or film attached on at least a portion of a surface of said substrate; and

c. at least one effector compound associated with said gel or film.

2. The coated material of claim 1, wherein polymer is a block copolymer or a polysaccharide.

7. The coated material of claim 1, wherein said compound is covalently associated with said gel or film or forms a physical interaction with said gel or film.

9. The coated material of claim 1, wherein said substrate is a part of, or in the form of a bead, microparticle, bandage, suture, catheter, stent, valve, pacemaker, conduit, cannula, appliance, scaffold, central line, pessary, tube, drain, trochar or plug.

10. The coated material of claim 9, wherein said catheter is a PA, pericardial, pleural, urinary or intra-abdominal catheter.

11. The coated material of claim 9, wherein said drain is a cerebrospinal fluid drain.

12. The coated material of claim 9, wherein said tube is a tracheostomy, endotracheal or chest tube.

13. The coated material of claim 1, wherein said substrate is a part of, or in the form of an implant, a rod, a screw, an orthopedic appliance, a pipe lining, a reactor, or equipment which comes into contact with food or seawater.

15. The coated material of claim 1, wherein said compound is released slowly, over a course of time or is minimally released over a course of time.

17. The coated material of claim 1, wherein said coated material may be affixed, glued, sutured to the skin, pierce the skin, or serves as a portal through which other coated materials are passed through the skin.

19. The coated material of claim 1, wherein said effector compound is an antibiotic, an antiviral, an antifungal, an anti-helminth, an anti-inflammatory, an antihistamine, an immunomodulatory, an anticoagulant, a surfactant, a bronchodilator, an antibody, a beta-adrenergic receptor inhibitor, a calcium channel blocker, an ace inhibitor, a growth factor, a hormone, a DNA, an siRNA, a vector or any combination thereof.

20. The coated material of claim 19, wherein said antifungal is a polyene antifungal.

21. The coated material of claim 20, wherein said antifungal is Amphotericin B.

22. The process of claim 35 wherein the gel or film is covalently attached to the coated material and to the effector compound, said process further comprising the step of

chemically reacting said gel or film with the effector compound.

24. The process of claim 22, wherein reacting comprises activating said gel to produce an active ester, amine- or thiol-reactive group or photoreactive group in said gel or film.

25. The process of claim 24, wherein said ester is N-hydroxy-succinimide ester.

36. The process of claim 35, wherein preparing said gel or film comprises the step of dispersing said polymer in water, dimethylsulfoxide, dimethylformamide or N-methylpyrrolidinone (NMP).

37. The process of claim 35, wherein attaching said gel or film to said substrate is via chemically reacting said gel or film with at least a portion of a surface of said substrate

38. The process of claim 37, wherein attaching comprises activating at least a portion of a surface of said coated material, and providing conditions whereby said gel or film reacts with said activated surface of said substrate.

39. The process of claim 35, wherein said polymer is a block copolymer or polysaccharide.

41. The process of claim 39, wherein said polysaccharide is a poly(pyranose) or a poly(furanose) or a combination thereof, or a dextran or an inulin.

40. (canceled)

41-1. The process of claim 35, wherein said effector compound is an antibiotic, an antiviral, an antifungal, an anti-helminth, an anti-inflammatory, an antihistamine, an immunomodulatory, an anticoagulant, a surfactant, a bronchodilator, an antibody, a beta-adrenergic receptor inhibitor, a calcium channel blocker, an ace inhibitor, a growth factor, a hormone, or any combination thereof.

42. (canceled)

44. The process of claim 43, wherein said antifungal is a polyene antifungal.

45. The process of claim 44, wherein said antifungal is Amphotericin B.

46. A method of preventing, diminishing or reducing the incidence of microbial attachment to a biomedical substrate or infection caused by introduction or implantation of a substrate in a subject, the method comprising attaching to a portion of a surface of said substrate, a gel or film comprising a polymer and at least one effector compound, wherein said effector compound is associated with the prevention, diminishment or reduction in microbial attachment or incidence of infection.

47. A method of preventing, diminishing or reducing the incidence of local fungal infection in a subject, said method comprising contacting a site of, or predisposed to infection with:

a. a substrate;

b. a gel or film comprising a polymer attached to said substrate in (a), on at least a portion of a surface of said substrate; and

c. said gel or film being associated with at least one effector compound;

wherein said at least one effector compound is associated with the prevention, diminiution or reduction of the incidence of said fungal infection.

48. The method of claim 47, wherein said compound is released slowly as a function of time, at said site of infection.

49. The method of claim 47, wherein said method results in diminished systemic toxicity of said effector compound.

50. The method of claim 47, wherein said effector compound is a polyene antifungal compound.

51. The method of claim 50, wherein said polyene antifungal compound is Amphotericin B.

52. The method of claim 47, wherein said substrate is a bead or particle ranging in size from about 50 nanometers-300 microns.

53. The method of claim 47, wherein said substrate is a contraceptive device.

54. (canceled)

55. A method of controlled release of an effector compound in a subject, said method comprising administering to or implanting in said subject:

a. a substrate;

b. a gel or film comprising a polymer attached on at least a portion of a surface of said substrate; and

c. at least one effector compound associated with said gel or film;

whereby said effector compound is released slowly, as a function of time, from said gel or film.

56. A topical composition for controlled delivery of a compound of interest, the composition comprising:

a. a particle;

b. a gel or film comprising a polymer attached on at least a portion of a surface of said particle; and

c. at least one compound of interest associated with said gel or film.

58. A method of controlled delivery of a compound of interest to a subject, said method comprising administering to said subject a composition comprising:

a. a particle

b. a gel or film comprising a polymer attached on at least a portion of a surface of said particle; and

c. at least one compound of interest associated with said gel or film.

57. The method of claim 58 wherein the delivery is topical c.

59. A method of treating, preventing, diminishing incidence, prolonging remission, prolonging latency, preventing relapse, preventing latency, ameliorating symptoms, or a combination thereof, of a disease in a subject, said method comprising administering to said subject:

a. a substrate

b. a gel or film comprising a polymer attached on at least a portion of a surface of said substrate; and

c. an effector compound associated with said gel or film;

whereby said effector compound is associated with treating, diminishing incidence, prolonging remission, preventing relapse, ameliorating symptoms of a disease in said subject.