Peritoneal Dialysis Methods and Apparatus
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0 Petitions
Accused Products
Abstract
A peritoneal-based (“bloodless”) artificial kidney processes peritoneal fluid without need for additional fluids (“waterless”). Fluid is separated into a protein-rich stream and a protein-free stream. The protein-rich stream is regenerated using a sorbent assembly, and its protein composition can be modified by removal of selected protein(s) (“dialysate-pheresis”). It is then reconstituted with additives and returned into the peritoneal cavity, thereby reducing protein-loss and providing oncotic-pressure for ultrafiltration. The protein-free stream is used to produce free water, and an alkaline or acid fluid for optimization of the composition of the regenerated stream. The unused protein-free stream can be used to “reverse flush” the separator to maintain its patency and the excess discarded for fluid-balance regulation. Compared to prior art, immobilization of urease allows more protein rich fluid to be regenerated and re-circulated into the peritoneal cavity for toxin removal and allows practicable development of portable and wearable artificial kidneys.
111 Citations
63 Claims
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1-38. -38. (canceled)
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39. A peritoneal dialysis system, comprising:
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a first fluid line that carries a fluid stream from a peritoneal cavity of the user; a separator that separates the fluid stream into a relatively protein-rich stream and a relatively protein-free stream, wherein the relatively protein-rich stream averages at least 15 vol % of the fluid stream over at least some period time; and a processing line that processes at least some of the relatively protein-rich stream to produce a modified dialysate stream; and a second fluid line that introduces at least some of the modified dialysate stream into the peritoneal cavity. - View Dependent Claims (40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63)
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Specification