METHODS FOR APPLYING ENERGY TO TISSUE USING ISOLATED ENERGY SOURCES

• US 20100217254A1
• Filed: 04/20/2009
• Published: 08/26/2010
• Est. Priority Date: 02/25/2009
• Status: Abandoned Application

• Current Assignee: Syneron Medical Limited (Syneron Incorporated)
• Original Assignee: Primaeva Medical, Inc. (Syneron Incorporated)
• Inventors: MEHTA, Bankim H.
• Application Number:
  US12/426,747
• Publication Number:
  US 20100217254A1
• Time in Patent Office: Days
• US Class Current: 606/33
• CPC Class Codes: A61B 18/14 Probes or electrodes therefor
• CPC Class Codes: A61B 18/1477 Needle-like probes
• CPC Class Codes: A61B 18/18 by applying electromagnetic radiation, e.g. microwaves radiation therapy A61N5/00
• CPC Class Codes: A61B 18/1815 using microwaves
• CPC Class Codes: A61B 18/203 applying laser energy to the outside of the body
• CPC Class Codes: A61B 2018/00005 Cooling or heating of the probe or tissue immediately surrounding the probe
• CPC Class Codes: A61B 2018/00011 with fluids
• CPC Class Codes: A61B 2018/00023 closed, i.e. without wound contact by the fluid
• CPC Class Codes: A61B 2018/00047 using Peltier effect
• CPC Class Codes: A61B 2018/0016 Energy applicators arranged in a two- or three dimensional array
• CPC Class Codes: A61B 2018/00452 Skin
• CPC Class Codes: A61B 2018/00458 Deeper parts of the skin, e.g. treatment of vascular disorders or port wine stains
• CPC Class Codes: A61B 2018/00464 Subcutaneous fat, e.g. liposuction, lipolysis
• CPC Class Codes: A61B 2018/0047 Upper parts of the skin, e.g. skin peeling or treatment of wrinkles
• CPC Class Codes: A61B 2018/00779 Power or energy
• CPC Class Codes: A61B 2018/00791 Temperature
• CPC Class Codes: A61B 2018/00875 Resistance or impedance
• CPC Class Codes: A61B 2018/1253 monopolar
• CPC Class Codes: A61B 2018/126 bipolar
• CPC Class Codes: A61B 2018/143 multiple needles
• CPC Class Codes: A61B 2018/1869 : with an instrument interstitially inserted into the body, e.g. needles
• CPC Class Codes: A61B 2090/3937 : Visible markers
• CPC Class Codes: A61B 2090/395 : with marking agent for marking skin or other tissue
• CPC Class Codes: A61N 2007/0047 : interstitial
• CPC Class Codes: A61N 7/00 : Ultrasound therapy lithotripsy A61B17/22, A61B17/225; massage using supersonic vibration A61H23/00 ; using ultrasound for introducing media into the body A61M37/0092

Abstract

The invention provides a system and method for percutaneous energy delivery in an effective, manner using one or more probes. Additional variations of the system include array of probes configured to minimize the energy required to produce the desired effect.

Claims

1. A method of creating a plurality of isolated lesions to improve a cosmetic appearance of tissue, the method comprising:

positioning a plurality of electrode pairs within tissue, each of the plurality of electrode pairs being respectively coupled to a plurality of energy sources each energy source being electrically isolated, where each electrode pair comprises a first and second electrodes of opposite polarity and where the isolated energy sources limit energy to flow between electrodes of the respectively coupled electrode pair;

identifying at least a first parameter of tissue located between electrodes of at least a first electrode pair;

identifying at least a second parameter of tissue located between electrodes of at least a second electrode pair;

supplying energy from a first isolated energy source to the first electrode pair in response to the first parameter to create a first fractional lesion between electrodes of the first electrode pair wherein the first isolated energy source limits energy to flow between electrodes of the first electrode pair; and

supplying energy from a second isolated energy source to the second electrode pair in response to the second parameter to create a second fractional lesion between electrodes of the second electrode pair and spaced from the first fractional lesion, wherein the second isolated energy source limits energy to flow between electrodes of the second electrode pair.

2. The method of claim 1, wherein the first and second fractional lesions are separated by a region of viable tissue.

3. The method of claim 1, wherein the first and second fractional lesions do not intersect.

4. The method of claim 1, wherein at least a portion of the first and second fractional intersect to form an intersected volume.

5. The method of claim 4, wherein the intersected volume is less than 50% of a volume of the first or second fractional lesion.

6. The method of claim 1, where supplying energy from the first and second isolated energy sources comprises limiting the supply of energy to create a spared region of tissue between the first fractional lesion and the second fractional lesion.

7. The method of claim 1, where confirming placement of the electrode pair comprises measuring an impedance of the tissue located between the electrodes of the electrode pair.

8. The method of claim 7, further comprising selecting the set of control parameters based on the measured impedance of the tissue.

9. The method of claim 7, further comprising selectively energizing one or more electrode pairs based on the respective impedance value of tissue located between the electrodes of the pair to pass current between the electrodes to damage the tissue and create at least one focal lesion, where the focal lesion is surrounded by uninjured tissue.

10. The method of claim 1, where the supply of the electrical current is adjusted during the application to maintain the temperature of the damaged tissue at a pre-determined temperature.

11. The method of claim 10, where the electrical current is limited to a maximum level pre-determined by a maximum power from the energy source.

12. The method of claim 10, where supplying the electrical current comprises supplying energy while maintaining the pre-determined temperature over an increased period of time to increase the volume of the fractional lesion to create a focal lesion in the reticular dermis layer, where the focal lesion comprises multiple fractional lesions.

13. The method of claim 10, supplying the electrical current further comprises comparing the measured temperature of the damaged tissue to the pre-predetermined temperature to control application of energy to prevent the measured temperature from exceeding the pre-determined temperature.

14. The method of claim 10, where supplying the electrical current comprises supplying the electrical current while maintaining a viability of an adnexal structure in the dermal layer.

15. The method of claim 10, where the pre-determined temperature is between 60 to 80 degrees Celsius.

16. The method of claim 15, where the application time is between 0 and 10 seconds.

17. The method of claim 14, where the adnexal structure comprises a structure selected from the group consisting of blood vessels, sweat glands, sebaceous glands, and hair follicles.

18. The method of claim 1, where positioning at least one electrode pair beneath a surface of the tissue comprises inserting an array of electrode pairs beneath the surface of the epidermis.

19. The method of claim 18, where inserting the array of electrode pairs comprises inserting the array of electrode pairs in an oblique angle.

20. The method of claim 19, further comprising cooling the surface of the tissue directly normal to the focal lesion.

21. The method of claim 1, where the method comprises creating a plurality of focal lesions separated by undamaged tissue, where the at least one electrode pair comprises a plurality of electrode pairs, and where selectively energizing the electrode pairs based on the respective impedance value of tissue located between the electrodes of the electrode pairs to create the plurality of focal lesions.

22. The method of claim 1, where supplying an electrical current from the energy source comprises selectively energizing one or more electrode pairs based on the respective impedance value of tissue located between the electrodes of the pair to create the focal lesion.

23. The method of claim 22, wherein selectively energizing one or more electrode pairs is performed sequentially by electrode pair.

24. The method of claim 1, further comprising providing an acceptable range of impedance values and preventing energy delivery to the electrodes if the measured impedance is outside of the acceptable range of impedance values.

25. The method of claim 1, further comprising providing an acceptable total amount of energy and preventing energy delivery to the electrodes if an amount of energy exceeds the acceptable total amount of energy.

26. The method of claim 1, further comprising providing an acceptable maximum temperature value and preventing energy delivery to the electrodes if the measured temperature exceeds the maximum temperature value.

27. The method of claim 1, where positioning at least one electrode pair beneath the surface of the skin in tissue comprises subsequently retracting the electrode pair while keeping the electrode pair in tissue to ensure proper placement of the electrode pair.

28. A method of improving a cosmetic appearance of skin by:

inserting a plurality of energy transfer units at least partially in a layer of target tissue, each of the plurality of the energy transfer unit being coupled to a plurality of isolated energy sources; and

applying energy to tissue through the energy transfer units such that each isolated energy source supplies energy to the respective energy transfer unit energy and prevents energy from passing between adjacent energy transfer units; and

controlling the energy to create at least a fractional lesion adjacent to each energy transfer unit and where each fractional lesion is surrounded by a layer of viable tissue.

29. The method of claim 28, where each energy transfer unit comprises a pair of energy transfer elements each having an opposite polarity.

30. The method of claim 28, where each energy transfer unit comprises one energy transfer element, the method further comprising coupling a plurality of ground elements to the tissue remotely from the target tissue, where each ground element forms a circuit with one energy transfer element and one isolated energy source.

31. The method of claim 28, where controlling the energy comprises creating each fractional lesion within a single layer of tissue.

32. The method of claim 31, where the layer comprises a reticular dermal layer.

33. The method of claim 28, where applying energy comprises maintaining a viability of an adnexal structure in the first layer of tissue.

34. The method of claim 33, where the adnexal structure comprises a structure selected from the group consisting of blood vessels, sweat glands, sebaceous glands, and hair follicles.

35. The method of claim 28, where the energy is selected from an energy modality selected from the group consisting of thermal, electrical, electromagnetic, microwave, mechanical, ultrasound, light, radiation, chemical, and radioactive.

36. The method of claim 28, the application of energy is selected to maintain the structural integrity of elastin.

37. The method of claim 28, wherein a volume occupied by each fractional lesion is totally embedded within the viable tissue

38. The method of claim 37, wherein the volume occupied by each fractional lesion is entirely beneath a surface of the skin.

39. The method of claim 37, wherein the volume of the fractional lesion is between 1 mm3 and 10 mm3.

40. The method of claim 37, wherein the volume occupied by the fractional lesion at least partially covers a surface of the energy transfer unit.

41. The method of claim 40, wherein the energy transfer unit comprises an electrode pair.

42. The method of claim 40, wherein the energy transfer unit comprises a single electrode, where the single electrode is capable of forming a closed loop with an external return electrode.

43. The method of claim 40, wherein the volume occupied by each fractional lesion totally covers a surface of the energy transfer unit.

44. The method of claim 40, wherein the volume occupied by each fractional lesion totally covers at least 50% of the surface of the energy transfer unit.

45. The method of claim 28, wherein controlling the energy to create each fractional comprises controlling the energy independently of a tissue impedance to create a volume of each fractional lesion.