Analyte Sensor Offset Normalization

• US 20100219085A1
• Filed: 02/08/2010
• Published: 09/02/2010
• Est. Priority Date: 02/27/2009
• Status: Abandoned Application

• Current Assignee: Edwards Lifesciences Corporation
• Original Assignee: Edwards Lifesciences Corporation
• Inventors: Oviatt, Henry W. JR.
• Application Number:
  US12/701,829
• Publication Number:
  US 20100219085A1
• Time in Patent Office: Days
• US Class Current: 205/782
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14865 invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
• CPC Class Codes: A61B 5/1495 Calibrating or testing of in-vivo probes

Abstract

Measurements of current from a working electrode and current from a blank electrode are received and a ratio corresponding to the ratio of surface areas of the working electrode and the blank electrode is determined. This ratio is used to correct any differential current offset between an analyte (working) electrode and a control (blank) electrode to yield a more accurate net current output. Systems, methods and computer program products are further described for measuring an analyte concentration disclosed are for calculating the amount of an analyte in a fluid using a biosensor.

Claims

1. A method of calculating the amount of an analyte in a fluid using a biosensor comprising:

providing said biosensor comprising a blank electrode and a working electrode;

receiving measurements of current from said working electrode and current from said blank electrode;

determining a normalization ratio corresponding to a ratio of the surface areas of said working electrode and said blank electrode; and

correcting an offset between the two electrodes using said normalization ratio.

2. The method of claim 1, wherein said determining a normalization ratio comprises dividing said working electrode current by said blank electrode current at a first time, and wherein said correcting an offset using said normalization ratio comprises determining a corrected blank electrode current by multiplying said blank electrode current at time subsequent to said first time by said normalization ratio.

3. The method of claim 2, further comprising calculating a net working current by subtracting said corrected blank electrode current from said working electrode current.

4. The method of claim 3, further comprising calibrating said net working current to an analyte concentration value.

5. The method of claim 4, further comprising outputting said calibrated net working current.

6. The method of claim 5, wherein said outputting occurs at a display for a sensor.

7. The method of claim 1, further comprising:

calculating a net working current by subtracting said blank electrode current from a corrected working electrode current,

wherein said determining a normalization ratio comprises dividing said working electrode current by said blank electrode current, and

wherein said correcting said offset using said normalization ratio comprises determining said correcting working electrode current by dividing said working electrode current by said normalization ratio.

8. The method of claim 1, wherein said determining a normalization ratio comprises calculating said normalization ratio by dividing said working electrode current by said blank electrode current.

9. The method of claim 1, wherein said determining a normalization ratio comprises:

measuring said working electrode surface area and said blank electrode surface area; and

calculating said normalization ratio by dividing said working electrode surface area by said blank electrode surface area.

10. The method of claim 1, wherein said receiving measurements of current from a working electrode and current from a blank electrode comprises:

exposing said working electrode and said blank electrode to a solution; and

measuring said working electrode current and said blank electrode current in response to exposing said working electrode and said blank electrode to said solution.

11. The method of claim 10, wherein said solution contains substantially no analyte solution.

12. The method of claim 10, wherein said solution comprises glucose.

13. The method of claim 1, wherein the normalization ratio is determined prior to completing a run-in of the electrode.

14. The method of claim 1, further comprising:

determining a second normalization ratio for a second working electrode current, the second normalization ratio corresponds to a ratio of the surface areas of said second working electrode and said blank electrode; and

correcting an offset between said second working electrode current and said blank electrode current using said second normalization ratio.

15. A method of calculating the amount of an analyte in a fluid using a biosensor, the method comprising:

providing said biosensor comprising a working electrode and a blank electrode;

determining a ratio of measured current from said working electrode and current measured from said blank electrode; and

calculating in said biosensor a net working current by subtracting said blank electrode current from a corrected working electrode current, said corrected working electrode current is determined by multiplying said measured working electrode current by said ratio.

16. The method of claim 15, wherein said ratio is determined by dividing said working electrode current by said blank electrode current.

17. The method of claim 15, wherein said corrected net working current is used to determine an analyte concentration.

18. A system for calculating the amount of an analyte in a fluid using a biosensor comprising:

a biosensor capable of sensing an analyte in the fluid and outputting a signal corresponding to an analyte concentration in the fluid, said biosensor comprising a working electrode and a blank electrode;

a controller configured to measure current from each of said electrodes; and

a processing unit in communication with said biosensor, wherein said processing unit is configured to respond to computer instructions to;

determine a normalization ratio corresponding to a ratio of the surface areas of said working electrode and said blank electrode; and

correct a differential current offset using said normalization ratio.

19. The system of claim 18, wherein said processing unit is further configured to calculate a net working current by subtracting a normalized blank electrode current from said working electrode current, said normalized blank electrode current calculated by multiplying said measured blank electrode current by said normalization ratio.

20. The system of claim 18, further comprising an output device connected to said processing unit in order to display values corresponding to an analyte concentration value.

21. The system of claim 18, wherein said processing unit is configured to determine said ratio by dividing said working electrode current by said blank electrode current.

22. The system of claim 18, wherein said processing unit is further configured to calibrate the measured output signal to an analyte concentration value.

23. A computer program product for calculating the amount of an analyte in a fluid using a biosensor, said computer program product comprising:

a computer usable medium having computer usable program code embodied therein, the computer usable medium comprising;

computer usable program code configured for receiving measurements of current from a working electrode and current from a blank electrode;

computer usable program code configured for determining a ratio of said working electrode and said blank electrode; and

computer usable program code configured for correcting an offset of said net working current by multiplying said ratio times said blank electrode current resulting in a corrected blank electrode current.

24. The computer program product of claim 23, said computer usable medium further comprising computer usable program code configured for calculating a net working current by subtracting said corrected blank electrode current from said working electrode current.