ANTIMICROBIAL COMPOSITIONS AND USES THEREOF

• US 20100221308A1
• Filed: 05/12/2010
• Published: 09/02/2010
• Est. Priority Date: 07/01/2005
• Status: Abandoned Application

• Current Assignee: Kane Biotech Inc.
• Original Assignee: Kane Biotech Inc.
• Inventors: LOVETRI, KAREN, GAWANDE, PURUSHOTTAM, MADHYASTHA, SRINIVASA
• Application Number:
  US12/778,208
• Publication Number:
  US 20100221308A1
• Time in Patent Office: Days
• US Class Current: 424/443
• CPC Class Codes: A01N 2300/00 Combinations or mixtures of active ingredients covered by classes A01N27/00 - A01N65/48 with other active or formulation relevant ingredients, e.g. specific carrier materials or surfactants, covered by classes A01N25/00 - A01N65/48
• CPC Class Codes: A01N 37/46 N-acyl derivatives
• CPC Class Codes: A01N 47/44 Guanidine; Derivatives thereof
• CPC Class Codes: A01N 61/00 Biocides, pest repellants or attractants, or plant growth regulators containing substances of unknown or undetermined composition, e.g. substances characterised only by the mode of action
• CPC Class Codes: A01N 63/50 Isolated enzymes; Isolated proteins peptides A01N37/46
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/155 Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
• CPC Class Codes: A61K 38/1703 from vertebrates
• CPC Class Codes: A61L 12/141 Biguanides, e.g. chlorhexidine
• CPC Class Codes: A61L 12/145 Polymeric quaternary ammonium compounds
• CPC Class Codes: A61L 2/18 Liquid substances or solutions comprising solids or dissolved gases
• CPC Class Codes: A61L 2300/206 Biguanides, e.g. chlorohexidine
• CPC Class Codes: A61L 2300/252 Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
• CPC Class Codes: A61L 2300/404 Biocides, antimicrobial agents, antiseptic agents
• CPC Class Codes: A61L 2300/42 Anti-thrombotic agents, anticoagulants, anti-platelet agents
• CPC Class Codes: A61L 27/34 Macromolecular materials
• CPC Class Codes: A61L 29/085 Macromolecular materials
• CPC Class Codes: A61L 29/16 Biologically active materials, e.g. therapeutic substances A61L29/048 takes precedence
• CPC Class Codes: A61P 1/02 Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
• CPC Class Codes: A61P 31/04 Antibacterial agents
• CPC Class Codes: C08L 89/00 : Compositions of proteins; Compositions of derivatives thereof foodstuff preparations A23J3/00

Abstract

The present invention includes compositions for preventing growth and proliferation of biofilm embedded microorganisms comprising: (a) a cationic polypeptide and (b) a bis-gaunide or a salt thereof. The invention further provides methods for preparing objects with such compositions, and objects and consumables (such as household cleaners) comprising such compositions.

Claims

1. A composition for decreasing growth or proliferation of biofilm embedded microorganisms, said composition comprising:

(a) a cationic polypeptide and (b) a bis-guanide or a salt thereof.

2. An oral care consumable product comprising the composition of claim 1.

3. The oral care consumable product according to claim 2, wherein said oral care consumable is selected from the group consisting of a toothpaste, a mouth wash, a dental floss, a chewing gum and a breath mint.

4. A cleaning product comprising the composition of claim 1.

5. The cleaning product of claim 4, wherein said cleaning product is selected from the group consisting of a general household disinfectant, a window cleaner, a bathroom cleaner, a kitchen cleaner, a floor cleaner, a laundry detergent, a cleaning supply;

a fruit and vegetable wash; and

a fabric softener.

6. A cosmetic product comprising the composition of claim 1.

7. The cosmetic product according to claim 6, wherein said cosmetic product is selected from a group consisting of:

face powder, a lip balm, a lipstick, an eyeliner, and a mascara.

8. A plastic product comprising the composition of claim 1.

9. The plastic product of claim 8, wherein said plastic product is selected from the group consisting of:

a toy;

a washing machine;

a toothbrush;

a denture;

a mouth guard;

a dairy line;

a dairy line filter;

a water line;

a line used in food and beverage manufacturing;

a cosmetic container;

a bottle;

a vacuum cleaner;

a vacuum cleaner filter;

an oil or gas pipe;

a window frame;

a door;

a door frame;

a humidifier;

a humidifier filter;

an outdoor pond liner;

an air filter;

a toilet seat;

a tupperware;

a shower;

a shower head;

a vacuum cleaner bag;

an HVAC system;

an HVAC filter;

a cooling tower;

a sink;

a tap and water spout;

a water jug;

a water sprinkling line;

a water sprinkler;

a bathtub;

a garbage bag;

a dishwasher;

a bathroom tile;

a bathroom fixture;

a dish drying tray;

a whirlpool bathtub;

a toilet;

a toilet lid;

a fish pond;

a swimming pool;

a swimming pool liner;

a swimming pool skimmer;

a swimming pool filter;

a planter;

a hot tub line;

a hot tub filter;

a medical instrument;

a dental instrument;

a washing machine liner;

an animal water dish;

a dish washer liner;

a food storage container;

a beverage storage container;

a dish;

a plate;

a bowl;

a cup;

a fork;

a knife;

a spoon;

a utensil;

a cutting board;

a garden hose;

a bird bath;

a hot tub; and

a counter top.

10. A wound care product comprising the composition of claim 1.

11. The wound care product of claim 10, wherein said wound care product is selected from the group consisting of band aids, non-resorbable gauze/sponge dressing, hydrophilic wound dressing, occlusive wound dressing, hydrogel wound and burn dressing, spray-applicator, ointments, lotions, cream and suture.

12. A product coated with the composition of claim 1.

13. The product of claim 12, wherein said product is selected from the group consisting of:

a denture;

a mouth guard;

a dairy line;

a water line;

an adhesive bandage;

a component of an HVAC system;

a component of a water treatment facility;

a component of a vacuum or a vacuum cleaner;

a vacuum cleaner bag;

a vacuum cleaner filter;

an air filter;

a component of a cooling tower;

a toy;

a window;

a door;

a window frame;

a door frame;

a medical instrument;

a dental instrument;

a bathroom tile;

a kitchen tile;

an animal water dish;

a washing machine;

a dish washer;

a towel;

a dish;

a bowl;

a utensil;

a cup;

a glass;

a cutting board;

a dish drying tray;

a whirlpool bathtub;

a sink;

a toilet;

a toilet seat;

a swimming pool;

a bird bath;

a planter;

a garden hose;

a fish pond;

an oil pipe;

a gas pipe;

a dairy line filter;

a line used in food and beverage manfufacturing;

a cosmetic container;

an outdoor pond liner;

a tap and water spout;

a humidifier;

a humidifier filter;

a bathroom tile;

a bathroom fixture;

a toilet lid;

a swimming pool liner;

a swimming pool skimmer;

a swimming pool filter;

a hot tub line;

a hot tub filter;

a washing machine liner;

a dishwasher liner;

an animal water dish;

a food storage container;

a beverage storage container;

a plate;

a cup;

a fork;

a knife;

a spoon;

a garbage bag; and

a countertop.

14. A paint comprising the composition of claim 1.

15. A method of preparing an object comprising treating at least one surface of the object with the composition of claim 1.

16. The method of claim 15, wherein the object is selected from the group consisting of:

a toothbrush;

dental floss;

a denture, a mouth guard;

a dairy line;

a dairy line filter;

a water line;

a line used in food and beverage manufacturing;

a cosmetic container;

a plastic bottle;

a vacuum;

a vacuum cleaner;

a tap and water spout;

an outdoor pond liner;

equipment involved in the leeching process or mining;

a water jug;

a water sprinkling line;

a water sprinkler;

a garbage bag;

tupperware;

a bath tub;

a sink;

a shower;

a shower head;

a dishwasher;

a vacuum cleaner bag;

a vacuum cleaner filter;

an oil or gas pipe;

a window frame;

a door;

a door frame;

a humidifier;

a humidifier filter;

HVAC systems and filters thereto, a toy;

a cooling tower;

a medical instrument;

a dental instrument;

a washing machine;

a washing machine liner;

a dishwasher;

a dishwasher liner;

a dish;

a plate;

a cup;

a utensil;

a bowl;

a fork;

a knife;

a spoon;

an animal water dish;

a bathroom tile;

a bathroom fixture;

a sealant;

grout;

a towel;

a food storage container;

a beverage storage container;

a cutting board;

a dish drying tray;

a whirlpool bathtub;

a toilet;

a toilet lid;

a toilet seat;

a fish pond;

a swimming pool;

a swimming pool liner;

a swimming pool skimmer;

a swimming pool filter;

a bird bath;

a garden hose;

a planter;

a hot tub;

a hot tub lines;

a hot tub filter; and

a counter top.

17. The oral care consumable product according to claim 2, wherein the cationic polypeptide is protamine sulfate and the bis-guanide is a chlorhexidine base or salt.

18. The cleaning product according to claim 4, wherein the cationic polypeptide is protamine sulfate and the bis-guanide is a chlorhexidine base or salt.

19. The plastic product according to claim 8, wherein the cationic polypeptide is protamine sulfate and the bis-guanide is a chlorhexidine base or salt.

20. The wound care product according to claim 10, wherein the cationic polypeptide is protamine sulfate and the bis-guanide is a chlorhexidine base or salt.