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Active Targeting Polymer Micelle Encapsulating Drug, and Pharmaceutical Composition

  • US 20100221320A1
  • Filed: 07/29/2009
  • Published: 09/02/2010
  • Est. Priority Date: 07/29/2008
  • Status: Active Grant
First Claim
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1. An active targeting polymer micelle encapsulating a drug, comprising a backbone polymer unit α

  • that has a target binding site and a backbone polymer unit β

    that has a drug and is free from the target binding site, the backbone polymer unit α and

    the backbone polymer unit β

    being disposed in a radial arrangement in a state where the target binding site is directed outward and the drug is directed inward, wherein;

    i) when the micelle is bound to a target while maintaining the radial arrangement, the micelle is taken up into a cell supplying the target through endocytosis, and the drug is released into the cell by collapse of the radial arrangement in the cell; and

    ii) when the radial arrangement collapses in blood before the micelle is bound to a target, the backbone polymer unit β

    is excreted through metabolism, to thereby prevent a normal cell from being damaged by the drug.

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