Nanoparticulate azelnidipine formulations
First Claim
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1. A stable nanoparticulate azelnidipine composition comprising:
- (a) particles of an azelnidipine or a salt having an average effective particle size of less than about 2000 nm; and
(b) at least one surface stabilizer.
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Abstract
The present invention is directed to compositions comprising a nanoparticulate azelnidipine, or a salt or derivative thereof, having improved bioavailability. The nanoparticulate azelnidipine particles of the composition have an effective average particle size of less than about 2000 nm and are useful in the treatment of hypertension and related diseases.
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Citations
29 Claims
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1. A stable nanoparticulate azelnidipine composition comprising:
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(a) particles of an azelnidipine or a salt having an average effective particle size of less than about 2000 nm; and (b) at least one surface stabilizer. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 29)
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- 22. A method of preparing a nanoparticulate azelnidipine, or a salt or derivative thereof, comprising contacting particles of an azelnidipine with at least one surface stabilizer for a time and under conditions sufficient to provide a nanoparticulate azelnidipine composition having an effective average particle size of less than about 2000 nm.
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24. A method for the treatment of hypertension or a related disease in a subject comprising administering to a subject of an effective amount of a composition comprising:
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(a) particles of azelnidipine or salt or derivative thereof having an average effective particle size of less than about 2000 nm; and (b) at least one surface stabilizer. - View Dependent Claims (25, 26, 27, 28)
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Specification