COMPOSITION FOR PRESERVING PLATELETS AND METHOD OF USING AND STORING THE SAME
First Claim
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1. A method for preserving platelets, comprising:
- admixing inactivated, functional platelets with a preservative composition comprising an effective amount of one or more pharmaceutically acceptable inhibitors of platelet activation to form preserved platelets;
storing the preserved platelets at a low temperature; and
removing the one or more inhibitors of platelet activation from the preserved platelets by diafiltration prior to transfusion,wherein said low temperature is in the range of about −
20°
C. to 12°
C.
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Abstract
The present invention relates to a method for preserving and storing platelets. The method includes the steps of admixing inactivated, functional platelets with a preservative composition comprising an effective amount of one or more pharmaceutically acceptable inhibitors of platelet activation to form preserved platelets, storing the preserved platelets at low temperature, and removing the one or more inhibitors of platelet activation from the preserved platelets by diafiltration prior to transfusion.
56 Citations
25 Claims
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1. A method for preserving platelets, comprising:
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admixing inactivated, functional platelets with a preservative composition comprising an effective amount of one or more pharmaceutically acceptable inhibitors of platelet activation to form preserved platelets; storing the preserved platelets at a low temperature; and removing the one or more inhibitors of platelet activation from the preserved platelets by diafiltration prior to transfusion, wherein said low temperature is in the range of about −
20°
C. to 12°
C. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25)
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Specification