PREVENTION OF SURGICAL ADHESIONS
First Claim
1. A method of treating, preventing, or minimizing adhesion formation during or following a surgical procedure comprising administering to a patient in need thereof a therapeutically effective amount of a compound selected from the group consisting of sunitinib malate, axitinib, semaxanib, sorafenib, ZD1839, and erlotinib.
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Accused Products
Abstract
The present invention relates to methods for treatment (particularly the prevention or suppression) of formation or reformation of adhesions, particularly in the peritoneal or pelvic cavities resulting from wound, surgery, infection, inflammation or trauma. The invention provides methods useful for inhibiting, suppressing or ameliorating adhesion formation in mammals, including humans wherein an individual is administered a compound selected from the group consisting of sunitinib malate, axitinib, semaxanib, sorafenib, ZD1839, and erlotinib. The invention applies to human and veterinary applications. The inventive method has been shown to be especially effective in preventing adhesion formation in the peritoneum following surgery.
12 Citations
11 Claims
- 1. A method of treating, preventing, or minimizing adhesion formation during or following a surgical procedure comprising administering to a patient in need thereof a therapeutically effective amount of a compound selected from the group consisting of sunitinib malate, axitinib, semaxanib, sorafenib, ZD1839, and erlotinib.
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2. A method of treating or preventing benign hypertrophic tumors comprising administering to a patient in need thereof a therapeutically effective amount of a compound selected from the group consisting of sunitinib malate, axitinib, semaxanib, sorafenib, ZD1839, and erlotinib.
- 3. A method of treating, preventing, or minimizing scar formation during or following a surgical procedure comprising administering to a patient in need thereof a therapeutically effective amount of a compound selected from the group consisting of sunitinib malate, axitinib, semaxanib, sorafenib, ZD1839, and erlotinib.
Specification