SYSTEM AND METHOD FOR NON-INVASIVE MONITORING OF CEREBRAL TISSUE HEMODYNAMICS

• US 20100222658A1
• Filed: 02/26/2010
• Published: 09/02/2010
• Est. Priority Date: 02/27/2009
• Status: Active Grant

• Current Assignee: Mespere LifeSciences Inc.
• Original Assignee: Mespere LifeSciences Inc.
• Inventors: Cheng, Xuefeng
• Granted Patent: US 8,463,348 B2
• Time in Patent Office: Days
• US Class Current: 600/324
• CPC Class Codes: A61B 5/14553 specially adapted for cerebral tissue
• CPC Class Codes: A61B 5/4064 Evaluating the brain A61B5/031, A61B5/369, A61B5/14553 take precedence
• CPC Class Codes: A61B 5/6833 Adhesive patches

Abstract

A method and system are provided which are useful for the non-invasive determination and monitoring of cerebral tissue oxygenation. The method comprises the steps of generating at least first and second jugular venous output signals against time based on the reflection of at least first and second wavelengths of light, respectively, from an external tissue site on the patient in the proximity of the internal jugular vein; obtaining corresponding first and second cardiac arterial output signals for the first and second wavelengths of light, respectively, from the patient, and separating the first and second cardiac arterial output signals from the first and second jugular venous output signals, respectively, to generate first and second cerebral venous output signals; and determining cerebral tissue oxygenation based on the first and second cerebral venous output signals. A system useful to monitor cerebral tissue oxygenation may comprise a first module for optically generating at least first and second jugular venous output signals against time at at least first and second wavelengths of light, respectively, from the patient; a second module for generating first and second cardiac arterial output signals at the first and second wavelengths of light, respectively, from the patient; and a signal processing means adapted to separate the first and second cardiac arterial output signals from the first and second jugular venous output signals, respectively, to yield first and second cerebral venous output signals, for the determination of cerebral tissue oxygenation.

Claims

1. A method for determining cerebral tissue oxygenation in a patient comprising the steps of:

1) generating at least first and second jugular venous output signals against time based on the reflection of at least first and second wavelengths of light, respectively, from an external tissue site on the patient in the proximity of the internal jugular vein;

2) obtaining corresponding first and second cardiac arterial output signals for the first and second wavelengths of light, respectively, from the patient, and separating the first and second cardiac arterial output signals from the first and second jugular venous output signals, respectively, to generate first and second cerebral venous output signals; and

3) determining cerebral tissue oxygenation based on the first and second cerebral venous output signals.

2. A method as defined in claim 1, wherein the first and second wavelengths of light are selected from wavelengths ranging from 400-1000 nm.

3. A method as defined in claim 1, wherein cardiac arterial output signals are obtained by pulse oximetry.

4. A method as defined in claim 1, wherein cerebral tissue oxygenation is determined using modified Beer Lambert'"'"'s law.

5. A system useful to determine and monitor cerebral tissue oxygenation in a patient comprising:

1) a first module for optically generating at least first and second jugular venous output signals against time at at least first and second wavelengths of light, respectively, from the patient;

2) a second module for generating at least first and second cardiac arterial output signals at the first and second wavelengths of light, respectively, from the patient; and

3) a signal processing means adapted to separate the first and second cardiac arterial output signals from the first and second jugular venous output signals, respectively, to yield first and second cerebral venous output signals, for the determination of cerebral tissue oxygenation.

6. A system as defined in claim 5, wherein the first module comprises at least one light emitting component and at least one light detecting component.

7. A system as defined in claim 6, wherein the light emitting component is a light source and light detecting component is a photodetector.

8. A system as defined in claim 7, comprising a photodetector for each light source.

9. A system as defined in claim 7, comprising two photodetectors for each light source.

10. A system as defined in claim 5, wherein the second module comprises a pulse oximeter.

11. A system as defined in claim 5, wherein the first and second wavelengths of light are within the range of about 400-1000 nm.

12. A system as defined in claim 11, wherein the first wavelength is about 690 nm and the second wavelength is about 830 nm.

13. A system as defined in claim 11, wherein the first and second wavelengths are selected from within a range of about 780 nm and 850 nm

14. A system as defined in claim 5, wherein the signal processing means comprises one or more microprocessors and a display unit.