REPLENISHABLE DRUG DELIVERY IMPLANT FOR BONE AND CARTILAGE

• US 20100222750A1
• Filed: 03/01/2010
• Published: 09/02/2010
• Est. Priority Date: 02/27/2009
• Status: Abandoned Application

• Current Assignee: Vanderbilt University
• Original Assignee: Vanderbilt University
• Inventors: Cheng, Joseph S.
• Application Number:
  US12/715,058
• Publication Number:
  US 20100222750A1
• Time in Patent Office: Days
• US Class Current: 604/288.40
• CPC Class Codes: A61B 17/70 Spinal positioners or stabilisers ; Bone stabilisers comprising fluid filler in an implant
• CPC Class Codes: A61B 17/7059 Cortical plates A61B17/7007, A61B17/7058 take precedence
• CPC Class Codes: A61B 17/864 hollow, e.g. with socket or cannulated
• CPC Class Codes: A61F 2/442 Intervertebral or spinal discs, e.g. resilient non-disc-shaped intervertebral inflatable pockets A61F2/441; non-disc-shaped intervertebral fusion implants A61F2/4455
• CPC Class Codes: A61F 2002/30677 Means for introducing or releasing pharmaceutical products, e.g. antibiotics, into the body
• CPC Class Codes: A61L 2430/38 for reconstruction of the spine, vertebrae or intervertebral discs

Abstract

A spinal implant comprising one or more integrated walls spaced apart to define an interior cavity configured to retain bone graft material, and having at least one aperture providing a pathway between the interior cavity and an exterior environment of the implant; wherein at least one of the one or more walls has a lumen therein, the lumen terminating at a post-operatively accessible refill port and at one or more drug delivery ports disposed in a surface of the at least one wall, and configured to allow drugs to flow from the refill port to the one or more delivery ports.

Claims

1. A spinal implant comprising:

one or more integrated walls spaced apart to define an interior cavity configured to retain bone graft material, and having at least one aperture providing a pathway between the interior cavity and an exterior environment of the implant;

wherein at least one of the one or more walls has a lumen therein, the lumen terminating at a post-operatively accessible refill port and at one or more drug delivery ports disposed in an exterior surface of the at least one wall, and configured to allow drugs to flow from the refill port to the one or more delivery ports.

2. The spinal implant of claim 1, wherein the one or more integrated walls collectively define top and bottom surfaces and load bearing members extending between the top and bottom surfaces.

3. The spinal implant of claim 2, wherein the top and bottom surfaces are each configured to contact one or more of bone and cartilage.

4. The spinal implant of claim 1, wherein the one or more integrated walls define a substantially cylindrical vertebral body cage implant.

5. The spinal implant of claim 1, wherein the least one aperture comprises a plurality of apertures formed in a spaced arrangement in the one or more integrated walls.

6. The spinal implant of claim 5, wherein the one or more integrated walls define a substantially cylindrical vertebral body cage implant, and further wherein the at least one aperture comprises a plurality of apertures circumferentially spaced around the cylindrical vertebral body cage implant.

7. The spinal implant of claim 1, wherein the at least one wall has a second lumen therein, the second lumen terminating at a second post-operatively accessible refill port and has at one or more second drug delivery ports disposed in an exterior surface of the at least one wall, and configured to allow drugs to flow from the refill port to the one or more second delivery ports.

8. The spinal implant of claim 1, wherein the refill port is configured to securely and detachably connect to a catheter.

9. The spinal implant of claim 1, wherein the spinal implant is configured to be implanted in at least one of a vertebral disc or a location of an explanted disc.

10. The spinal implant of claim 1, wherein the spinal implant is a spinal bone implant.

11. The spinal implant of claim 10, wherein the bone implant is a pedicle screw.

12. The spinal implant of claim 10, wherein the bone implant is configured to be implanted in the vertebral body.

13. The spinal implant of claim 1, wherein the flow rate through the one or more drug delivery ports is externally controllable.

14. The spinal implant of claim 2, further comprising:

an extension configured to be detachably connected to the top surface of the one or more integrated walls.

15. A bone implant comprising:

one or more integrated walls spaced apart to define an interior cavity configured to retain bone graft material, and having at least one aperture providing a pathway between the interior cavity and an exterior environment of the implant;

wherein at least one of the one or more walls has a lumen therein, the lumen terminating at a post-operatively accessible refill port and at one or more drug delivery ports disposed in an exterior surface of the at least one wall, and configured to allow drugs to flow from the refill port to the one or more delivery ports.

16. The bone implant of claim 15, wherein the one or more integrated walls collectively define top and bottom surfaces and load bearing members extending between the top and bottom surfaces.

17. The bone implant of claim 16, wherein the top and bottom surfaces are each configured to contact one or more of bone and cartilage.

18. The bone implant of claim 15, wherein the one or more integrated walls define a substantially cylindrical vertebral body cage implant.

19. The bone implant of claim 15, wherein the least one aperture comprises a plurality of apertures formed in a spaced arrangement in the one or more integrated walls.

20. The bone implant of claim 19, wherein the one or more integrated walls define a substantially cylindrical vertebral body cage implant, and further wherein the at least one aperture comprises a plurality of apertures circumferentially spaced around the cylindrical vertebral body cage implant.

21. The bone implant of claim 15, wherein the at least one wall has a second lumen therein, the second lumen terminating at a second post-operatively accessible refill port and has at one or more second drug delivery ports disposed in an exterior surface of the at least one wall, and configured to allow drugs to flow from the refill port to the one or more second delivery ports.

22. The bone implant of claim 15, wherein the refill port is configured to securely and detachably connect to a catheter.

23. The bone implant of claim 15, wherein the bone implant is a spinal bone implant.

24. The bone implant of claim 15, wherein the bone implant is a pedicle screw.

25. The bone implant of claim 15, wherein the bone implant is configured to be implanted in the vertebral body.

26. The bone implant of claim 15, wherein the flow rate through the one or more drug delivery ports is externally controllable.

27. The bone implant of claim 16, further comprising:

an extension configured to be detachably connected to the top surface of the one or more integrated walls.

28. A spinal implant system comprising:

a spinal implant having;

one or more integrated walls spaced apart to define an interior cavity configured to retain bone graft material, and having at least one aperture providing a pathway between the interior cavity and an exterior environment of the implant,

wherein at least one of the one or more walls has a lumen therein, the lumen terminating at a post-operatively accessible refill port and at one or more drug delivery ports disposed in an exterior surface of the at least one wall, and configured to allow drugs to flow from the refill port to the one or more delivery ports; and

a drug source fluidically coupled to the refill port of the spinal implant.

29. The implant system of claim 28, wherein the drug source comprises:

an injection port configured to receive a needle therein.

30. The implant system of claim 28, wherein the drug source comprises:

an implantable fluid reservoir.

31. The implant system of claim 28, wherein the drug source comprises:

an implantable active drug infusion device.

32. The implant system of claim 28, wherein the drug source comprises:

an implantable passive drug infusion device.

33. The implant system of claim 28, wherein the one or more integrated walls collectively define top and bottom surfaces and load bearing members extending between the top and bottom surfaces.

34. The implant system of claim 28, wherein the one or more integrated walls define a substantially cylindrical vertebral body cage implant.

35. The implant system of claim 28, wherein the at least one wall has a second lumen therein, the second lumen terminating at a second post-operatively accessible refill port and has at one or more second drug delivery ports disposed in an exterior surface of the at least one wall, and configured to allow drugs to flow from the refill port to the one or more second delivery ports.

36. The implant system of claim 28, wherein the refill port is configured to be fluidically coupled to the drug source via a catheter.

37. The implant system of claim 36, wherein the catheter is detachable connected to the refill port.

38. The implant system of claim 28, wherein the drug source is externally replenishable.

39. The implant system of claim 28, wherein the spinal implant is a spinal bone implant.

40. The implant system of claim 39, wherein the bone implant is a pedicle screw.

41. The implant system of claim 28, wherein the flow rate through the one or more drug delivery ports is externally controllable.

42. The implant system of claim 29, further comprising:

an extension configured to be detachably connected to the top surface of the one or more integrated walls.

43. A method of using a spinal implant comprising one or more integrated walls spaced apart to define an interior cavity configured to retain bone graft material, and having at least one aperture providing a pathway between the interior cavity and an exterior environment of the implant, wherein at least one of the one or more walls has a lumen therein, the lumen terminating at a post-operatively accessible refill port and at one or more drug delivery ports disposed in an exterior surface of the at least one wall, the method comprising:

implanting the spinal implant into a vertebral body of a patient;

fluidcally coupling the refill port to a drug source; and

delivering drugs from the drug source to the refill port to facilitate the flow of drugs from the refill port to the one or more delivery ports.

44. The method of claim 43, wherein the drug source comprises an externally accessible injection port, and wherein delivering drugs from the drug source comprises:

injecting drugs into the injection port via syringe.

45. The method of claim 43, wherein the drug source comprises an implantable active drug infusion device, and wherein delivering drugs from the drug source comprises:

delivering drugs from the active drug infusion device.

46. The method of claim 43, wherein the drug source comprises an implantable passive drug infusion device, and wherein delivering drugs from the drug source comprises:

delivering drugs from the passive drug infusion device.

47. The method of claim 43, further comprising:

performing a corpectomy to remove damaged portions of the vertebral body; and

inserting the spinal implant into the cavity created by the corpectomy.

48. The method of claim 43, further comprising:

securing the spinal implant to the patient via set screws.