OPHTHALMIC FLUID DELIVERY SYSTEM

• US 20100222752A1
• Filed: 12/30/2009
• Published: 09/02/2010
• Est. Priority Date: 05/20/2003
• Status: Abandoned Application

• Current Assignee: Optimyst Systems Inc.
• Original Assignee: Optimyst Systems Inc.
• Inventors: Collins, James F. JR., Jobin, Michael J.
• Application Number:
  US12/650,008
• Publication Number:
  US 20100222752A1
• Time in Patent Office: Days
• US Class Current: 604/296
• CPC Class Codes: A61B 17/20 for vaccinating or cleaning the skin previous to the vaccination diagnosis by vaccination other than by injuring the skin A61B10/0035 ; apparatus for injections A61M
• CPC Class Codes: A61F 9/0008 Introducing ophthalmic products into the ocular cavity or retaining products therein putting in contact lenses A61F9/0061; introducing or retaining media in cavities of the body in general A61M31/00
• CPC Class Codes: A61M 11/005 using ultrasonics spraying or atomising liquids using ultrasonic vibrations in general B05B17/06
• CPC Class Codes: A61M 11/042 electrical
• CPC Class Codes: A61M 11/065 using steam as driving gas
• CPC Class Codes: A61M 2205/3372 Temperature compensation
• CPC Class Codes: A61M 2205/3386 Low level detectors
• CPC Class Codes: A61M 2205/3653 by Joule effect, i.e. electric resistance
• CPC Class Codes: A61M 2205/368 by electromagnetic radiation, e.g. IR waves
• CPC Class Codes: A61M 2205/50 with microprocessors or computers
• CPC Class Codes: A61M 2205/581 by audible feedback
• CPC Class Codes: A61M 2205/583 by visual feedback
• CPC Class Codes: A61M 2205/8206 battery-operated
• CPC Class Codes: A61M 2210/0612 Eyes
• CPC Class Codes: B05B 17/0623 coupled with a vibrating horn
• CPC Class Codes: B05B 17/063 having an internal channel for supplying the liquid or other fluent material
• CPC Class Codes: B05B 17/0646 Vibrating plates, i.e. plates being directly subjected to the vibrations, e.g. having a piezoelectric transducer attached thereto

Abstract

An ophthalmic fluid atomizer including a body having a proximal end and a distal end and a container connected to the body, wherein the container contains an ophthalmic fluid disposed therein. The atomizer further including a discharge plate disposed at the distal end and a wick extending from the container to the discharge plate and transmitting the ophthalmic fluid from the container to the discharge plate via capillary action. Transmission of the ophthalmic fluid across the discharge plate generates a plume of ophthalmic fluid along a direction directly toward the eye, wherein the plume of ophthalmic fluid travels unassisted from the discharge plate to the eye and at the eye has a momentum subliminal to at least one of an ocular blink reflex and a lacrimation reflex of the eye. The atomizer further includes a processor that controls vibration of the discharge plate which causes an aerosol mist to form and an activation switch operatively coupled to the processor to activate the transmission of the ophthalmic fluid from the discharge plate.

Claims

1. An ophthalmic fluid atomizer configured to safely deliver an ophthalmic fluid to an eye, the ophthalmic fluid atomizer comprising:

a body having a proximal end and a distal end;

a container connected to the body, wherein the container contains an ophthalmic fluid disposed therein;

a discharge plate disposed at the distal end, wherein the discharge plate includes a plurality of openings extending therethrough;

a wick extending from the container to the discharge plate and transmitting the ophthalmic fluid from the container to the discharge plate via capillary action, wherein transmission of the ophthalmic fluid across the discharge plate generates a plume of ophthalmic fluid along a direction directly toward the eye, wherein the plume of ophthalmic fluid travels unassisted from the discharge plate to the eye and at the eye has a momentum subliminal to at least one of an ocular blink reflex and a lacrimation reflex of the eye;

a processor that controls vibration of the discharge plate which causes an aerosol mist to form;

an activation switch operatively coupled to the processor to activate the processor.

2. The ophthalmic fluid atomizer according to claim 1, wherein the atomizer discharges the ophthalmic fluid having a velocity of between approximately 4 and 30 centimeters per second.

3. The ophthalmic fluid atomizer according to claim 1, wherein the atomizer discharges the ophthalmic fluid between approximately 2 and 10 microliters per second.

4. The ophthalmic fluid atomizer according to claim 1, wherein the atomizer operates for approximately 0.5 to 5 seconds upon activation of the activation switch.

5. The ophthalmic fluid atomizer according to claim 1, wherein the atomizer discharges the ophthalmic fluid having average particle sizes between approximately 0.5 and 10 microns in diameter.

6. The ophthalmic fluid atomizer according to claim 1, wherein the activation switch is configured to generate a signal to the processor that leads to controlling transmission of the ophthalmic fluid for a predetermined period of time, the predetermined period of time having a duration which is independent of operation of the activation switch.

7. The ophthalmic fluid atomizer according to claim 1, wherein the container is removable.

8. The ophthalmic fluid atomizer according to claim 1, wherein the ophthalmic fluid is selected from the group consisting of mydriatics/cycloplegics, anesthetics, flourescein, flourescein/anesthetic combinations, mydriatic reversal agents, ophthalmic decongestants, ophthalmic lubricants, and glaucoma medications.

9. The ophthalmic fluid atomizer according to claim 8, wherein the glaucoma medications are selected from the group consisting of prestaglandins, beta blockers, alpha adrenergic agents, carbonic anhydrase inhibitors, and miotics.

10. The ophthalmic fluid atomizer according to claim 1, wherein the plume of ophthalmic fluid has a volume that can entirely be retained by the eye.

11. The ophthalmic fluid atomizer according to claim 1, wherein the plume of ophthalmic fluid has a volume of at most approximately 5 micro liters.

12. The ophthalmic fluid atomizer of claim 1, wherein the plume of ophthalmic fluid contains an amount of ophthalmic medicine and the momentum of the plume is such that substantially all of the amount of ophthalmic medicine is received and retained by the human eye.

13. The ophthalmic fluid atomizer of claim 1, wherein the mist contains an amount of ophthalmic medicine and the momentum of the mist is such that substantially all of the amount of ophthalmic medicine is received and retained by the human eye 14.

14. The ophthalmic fluid atomizer according to claim 1, wherein the atomizer discharges the ophthalmic fluid having a velocity of between approximately 4 and 30 centimeters per second.

15. The ophthalmic fluid atomizer according to claim 1, further comprising a cap that encloses the discharge plate and wherein at least a portion of the cap is transparent;

and wherein the container comprises indicia that identifies the ophthalmic fluid, the indicia being visible to an observer via the at least a portion of the cap that is transparent.

16. The ophthalmic fluid atomizer according to claim 1, further comprising a glowing ring surrounding the discharge plate.

17. The ophthalmic fluid atomizer according to claim 15, further comprising a glowing ring surrounding the discharge plate.

18. The ophthalmic fluid atomizer according to claim 1, wherein the processor controls vibration of the discharge plate so that a sequence of pulses of mist is delivered to the eye.

19. The ophthalmic fluid atomizer according to claim 1, wherein the processor applies pulse width modulation to control vibration of the discharge plate so as to control a flow rate of the mist.

20. The ophthalmic fluid atomizer according to claim 1, wherein the wick is coated with a coating selected from the group consisting of ionic silver and PTFE.

21. The ophthalmic fluid atomizer according to claim 1, wherein the discharge plate is coated with a coating selected from the group consisting of ionic silver and PTFE.

22. The ophthalmic fluid atomizer according to claim 1, further comprising a diaphragm positioned between the wick and the discharge plate, the diaphragm being in an open position when the mist is generated and in a closed position otherwise.

23. The ophthalmic fluid atomizer according to claim 22, wherein the wick or discharge plate automatically move relative to one another when the diaphragm moves from the open position to the closed position.

24. The ophthalmic fluid atomizer according to claim 21, further comprising a diaphragm positioned between the wick and the discharge plate, the diaphragm being in an open position when the mist is generated and in a closed position otherwise.

25. The ophthalmic fluid atomizer according to claim 24, wherein the wick or discharge plate automatically move relative to one another when the diaphragm moves from the open position to the closed position.

26. The ophthalmic fluid atomizer according to claim 25, wherein UV light, low pH formulations and chemically preserved solutions are applied to the discharge plate in order to prevent microbial contamination of the mist.

27. The ophthalmic fluid atomizer according to claim 1, wherein UV light is applied to the discharge plate in order to prevent microbial contamination of the mist.

28. The ophthalmic fluid atomizer according to claim 1, further comprising a diaphragm positioned so that the discharge plate lies between the diaphragm and the wick, the diaphragm being in an open position when the mist is generated and in a closed position otherwise.

29. An ophthalmic fluid atomizer configured to safely deliver an ophthalmic fluid to an eye, the ophthalmic fluid atomizer comprising:

a body having a proximal end and a distal end;

a medule system releasably connected to the body, the medule system comprising;

a container containing an ophthalmic fluid disposed therein and defining a first opening; and

a wick that is inserted into the opening and extending into the container so as to contact the ophthalmic fluid.

a discharge plate disposed at the distal end, wherein the discharge plate includes a plurality of openings extending therethrough;

wherein the wick extends from the container to the discharge plate and transmits the ophthalmic fluid from the container to the discharge plate via capillary action, wherein transmission of the ophthalmic fluid across the discharge plate generates a plume of ophthalmic fluid along a direction directly toward the eye, wherein the plume of ophthalmic fluid travels unassisted from the discharge plate to the eye and at the eye has a momentum subliminal to at least one of an ocular blink reflex and a lacrimation reflex of the eye.

30. The ophthalmic fluid atomizer of claim 29, wherein the medule system, comprises a plug inserted into the opening, the plug defining a second opening through which the wick is inserted.

31. The medule system of claim 30, wherein the container comprises a neck portion that comprises a first thread, wherein the plug engages the neck via an interference fit.

32. The medule system of claim 30, wherein the opening is aligned with the second opening.

33. The medule of claim 29, wherein the ophthalmic fluid is selected from the group consisting of mydriatics/cycloplegics, anesthetics, flourescein, flourescein/anesthetic combinations, mydriatic reversal agents, ophthalmic decongestants, ophthalmic lubricants, and glaucoma medications.

34. The medule of claim 33, wherein the glaucoma medications are selected from the group consisting of prestaglandins, beta blockers, alpha adrenergic agents, carbonic anhydrase inhibitors, and miotics.

35. A medule system, comprising:

a container containing an ophthalmic fluid disposed therein and defining a first opening;

a plug inserted into the first opening, the plug defining a second opening; and

a wick that is inserted into the first opening and the second opening and extending into the container so as to contact the ophthalmic fluid.

36. The medule system of claim 35, wherein the container comprises a neck portion that comprises a first thread, wherein the plug engages the neck via an interference fit.

37. The medule system of claim 35, wherein the first opening is aligned with the second opening.

38. The medule of claim 35, wherein the ophthalmic fluid is selected from the group consisting of mydriatics/cycloplegics, anesthetics, flourescein, flourescein/anesthetic combinations, mydriatic reversal agents, ophthalmic decongestants, ophthalmic lubricants, and glaucoma medications.

39. The medule of claim 38, wherein the glaucoma medications are selected from the group consisting of prestaglandins, beta blockers, alpha adrenergic agents, carbonic anhydrase inhibitors, and miotics.

40. An ophthalmic fluid atomizer configured to safely deliver an ophthalmic fluid to an eye, the ophthalmic fluid atomizer comprising:

a body having a proximal end and a distal end;

a container connected to the body, wherein the container contains an ophthalmic fluid disposed therein;

a discharge plate disposed at the distal end, wherein the discharge plate includes a plurality of openings extending therethrough;

a prime mover extending from the container to the discharge plate and transmitting the ophthalmic fluid from the container to the discharge plate, wherein transmission of the ophthalmic fluid across the discharge plate generates a plume of ophthalmic fluid along a direction directly toward the eye, wherein the plume of ophthalmic fluid travels unassisted from the discharge plate to the eye and at the eye has a momentum subliminal to at least one of an ocular blink reflex and a lacrimation reflex of the eye;

a glowing alignment device surrounding the discharge plate;

a processor that controls vibration of the discharge plate which cause an aerosol mist to form;

an activation switch operatively coupled to the processor to activate the processor.

41. The ophthalmic fluid atomizer according to claim 40, wherein the alignment device comprises a light pipe and an illumination device for dispersing light into the light pipe.

42. The ophthalmic fluid atomizer according to claim 41, wherein the light pipe is symmetrically positioned with respect to the prime mover.

43. The ophthalmic fluid atomizer according to claim 40, wherein the prime mover comprises a wick.

44. The ophthalmic fluid atomizer according to claim 40, wherein the ophthalmic fluid is selected from the group consisting of mydriatics/cycloplegics, anesthetics, flourescein, flourescein/anesthetic combinations, mydriatic reversal agents, ophthalmic decongestants, ophthalmic lubricants, and glaucoma medications.

45. The ophthalmic fluid atomizer according to claim 44, wherein the glaucoma medications are selected from the group consisting of prestaglandins, beta blockers, alpha adrenergic agents, carbonic anhydrase inhibitors, and miotics.

46. An ophthalmic fluid atomizer configured to safely deliver an ophthalmic fluid to an eye, the ophthalmic fluid atomizer comprising:

a body having a proximal end and a distal end;

a container connected to the body, wherein the container contains an ophthalmic fluid disposed therein and the container comprises indicia indicative of the identity of the ophthalmic fluid;

a discharge plate disposed at the distal end, wherein the discharge plate includes a plurality of openings extending therethrough;

a prime mover extending from the container to the discharge plate and transmitting the ophthalmic fluid from the container to the discharge plate, wherein transmission of the ophthalmic fluid across the discharge plate generates a plume of ophthalmic fluid along a direction directly toward the eye, wherein the plume of ophthalmic fluid travels unassisted from the discharge plate to the eye and at the eye has a momentum subliminal to at least one of an ocular blink reflex and a lacrimation reflex of the eye;

a cap that covers the discharge plate and the prime mover, wherein a portion of the cap is transparent and positioned so that a user can see the indicia through the portion of the cap.

47. The ophthalmic fluid atomizer according to claim 46, further comprising:

a processor that controls vibration of the discharge plate which cause an aerosol mist to form; and

an activation switch operatively coupled to the processor to activate the processor.

48. The ophthalmic fluid atomizer according to claim 46, wherein the cap is totally transparent.

49. The ophthalmic fluid atomizer according to claim 46, wherein the prime mover comprises a wick.

50. The ophthalmic fluid atomizer according to claim 46, wherein the ophthalmic fluid is selected from the group consisting of mydriatics/cycloplegics, anesthetics, flourescein, flourescein/anesthetic combinations, mydriatic reversal agents, ophthalmic decongestants, ophthalmic lubricants, and glaucoma medications.

51. The ophthalmic fluid atomizer according to claim 50, wherein the glaucoma medications are selected from the group consisting of prestaglandins, beta blockers, alpha adrenergic agents, carbonic anhydrase inhibitors, and miotics.

52. An ophthalmic fluid atomizer configured to safely deliver an ophthalmic fluid to an eye, the ophthalmic fluid atomizer comprising:

a body having a proximal end and a distal end;

a container connected to the body, wherein the container contains an ophthalmic fluid disposed therein;

a discharge plate disposed at the distal end, wherein the discharge plate includes a plurality of openings extending therethrough;

a prime mover extending from the container to the discharge plate and transmitting the ophthalmic fluid from the container to the discharge plate, wherein transmission of the ophthalmic fluid across the discharge plate generates a plume of ophthalmic fluid along a direction directly toward the eye, wherein the plume of ophthalmic fluid travels unassisted from the discharge plate to the eye and at the eye has a momentum subliminal to at least one of an ocular blink reflex and a lacrimation reflex of the eye;

a closure element that moves from a first position to a second position, wherein the closure element at the first position prevents the plume from reaching the eye and the closure element at the second position allows the plume to reach the eye.

53. The ophthalmic fluid atomizer according to claim 52, wherein the prime mover or discharge plate automatically move relative to one another when the closure element moves from the first position to the second position.

54. The ophthalmic fluid atomizer according to claim 52, wherein the discharge plate is positioned between the prime mover and the closure element.

55. The ophthalmic fluid atomizer according to claim 54, wherein the closure element is a pivoting cap.

56. The ophthalmic fluid atomizer according to claim 52, wherein the closure element is positioned between the prime mover and the discharge plate.

57. The ophthalmic fluid atomizer according to claim 56, wherein the closure element is an iris diaphragm.

58. The ophthalmic fluid atomizer according to claim 53, wherein the discharge plate is positioned between the prime mover and the closure element.

59. The ophthalmic fluid atomizer according to claim 58, wherein the closure element is a pivoting cap.

60. The ophthalmic fluid atomizer according to claim 52, wherein the prime mover comprises a wick.

61. The ophthalmic fluid atomizer according to claim 52, wherein the ophthalmic fluid is selected from the group consisting of mydriatics/cycloplegics, anesthetics, flourescein, flourescein/anesthetic combinations, mydriatic reversal agents, ophthalmic decongestants, ophthalmic lubricants, and glaucoma medications.

62. The ophthalmic fluid atomizer according to claim 52, wherein the glaucoma medications are selected from the group consisting of prestaglandins, beta blockers, alpha adrenergic agents, carbonic anhydrase inhibitors, and miotics.