IMPLANT WITH HIGH VAPOR PRESSURE MEDIUM

• US 20100222802A1
• Filed: 11/24/2009
• Published: 09/02/2010
• Est. Priority Date: 04/14/2000
• Status: Active Grant

• Current Assignee: Solace Therapeutics, Inc.
• Original Assignee: Attenuex Technologies, Inc.
• Inventors: Dayton, Peter, Gillespie, John JR., Schutt, Ernest G., Connors, Kevin G.
• Granted Patent: US 8,574,146 B2
• Time in Patent Office: Days
• US Class Current: 606/192
• CPC Class Codes: A61B 1/307 for the urinary organs, e.g. urethroscopes, cystoscopes
• CPC Class Codes: A61B 17/00234 for minimally invasive surgery A61B17/0218, A61B17/0469, A61B17/12013, A61B17/1285, A61B17/29, A61B17/320016 take precedence
• CPC Class Codes: A61B 17/0401 Suture anchors, buttons or pledgets, i.e. means for attaching sutures to bone, cartilage or soft tissue; Instruments for applying or removing suture anchors A61B17/0642 takes precedence; fixation devices for tendons or ligaments A61F2/0811
• CPC Class Codes: A61B 17/221 Gripping devices in the form of loops or baskets for gripping calculi or similar types of obstructions surgical snare instruments A61B17/32056
• CPC Class Codes: A61B 17/32056 Surgical snare instruments for removing or smashing calculi A61B2017/2212; tonsillotomes A61B17/26
• CPC Class Codes: A61B 17/3468 for implanting or removing devices, e.g. prostheses, implants, seeds, wires devices for implanting seeds A61M37/0069
• CPC Class Codes: A61B 17/3478 Endoscopic needles, e.g. for infusion biopsy needles A61B10/0233; catheters with injection needles A61M25/0067
• CPC Class Codes: A61B 17/66 Alignment, compression or distraction mechanisms
• CPC Class Codes: A61B 17/70 Spinal positioners or stabilisers ; Bone stabilisers comprising fluid filler in an implant
• CPC Class Codes: A61B 17/7065 Devices with changeable shape, e.g. collapsible or having retractable arms to aid implantation; Tools therefor
• CPC Class Codes: A61B 17/7098 wherein the implant is permeable or has openings, e.g. fenestrated screw hollow surgical screws A61B17/864
• CPC Class Codes: A61B 17/82 for bone cerclage apparatus for manipulating wires or straps A61B17/8861; wires, bands or straps other than cerclage A61B17/842
• CPC Class Codes: A61B 18/1442 Probes having pivoting end effectors, e.g. forceps
• CPC Class Codes: A61B 2017/00539 hydraulically
• CPC Class Codes: A61B 2017/00557 inflatable A61B2017/22051 takes precedence
• CPC Class Codes: A61B 2017/00858 high friction or non-slip
• CPC Class Codes: A61B 2017/0435 the barbs being separate elements mechanically linked to the anchor, e.g. by pivots
• CPC Class Codes: A61B 2017/22035 for retrieving or repositioning foreign objects
• CPC Class Codes: A61B 2017/22062 to be filled with liquid
• CPC Class Codes: A61B 2017/2215 having an open distal end
• CPC Class Codes: A61B 5/205 : Determining bladder or urethral pressure
• CPC Class Codes: A61B 90/02 : Devices for expanding tissue, e.g. skin tissue implements for holding wounds open, surgical tractors A61B17/02; implantable mammary prosthesis A61F2/12; dilators A61M29/00
• CPC Class Codes: A61F 13/20 : Tampons, e.g. catamenial tampons; Accessories therefor
• CPC Class Codes: A61F 13/26 : Means for inserting tampons , i.e. applicators
• CPC Class Codes: A61F 2/0027 : inflatable
• CPC Class Codes: A61F 2/004 : inflatable
• CPC Class Codes: A61F 2/0059 : Cosmetic or alloplastic implants A61F2/10 - A61F2/16, A61F2/28 take precedence
• CPC Class Codes: A61F 2/042 : Urinary bladders
• CPC Class Codes: A61F 2/10 : Hair or skin implants
• CPC Class Codes: A61F 2/12 : Mammary prostheses and implants
• CPC Class Codes: A61F 2/2481 : Devices outside the heart wall, e.g. bags, strips or bands
• CPC Class Codes: A61F 2/26 : Penis implants
• CPC Class Codes: A61F 2002/30617 : Visible markings for adjusting, locating or measuring
• CPC Class Codes: A61F 2002/3071 : Identification means; Administration of patients
• CPC Class Codes: A61F 2250/0059 : temporary
• CPC Class Codes: A61F 2250/0067 : Means for introducing or releasing pharmaceutical products into the body
• CPC Class Codes: A61F 2250/0068 : the pharmaceutical product being in a reservoir
• CPC Class Codes: A61F 2250/0085 : Identification means; Administration of patients
• CPC Class Codes: A61F 2250/0097 : Visible markings, e.g. indicia
• CPC Class Codes: A61F 5/0013 : Implantable devices or invasive measures
• CPC Class Codes: A61F 9/00781 : Apparatus for modifying intraocular pressure, e.g. for glaucoma treatment drainage implants in general A61M27/002
• CPC Class Codes: A61M 2025/0076 : Unidirectional valves
• CPC Class Codes: A61M 2025/1054 : having detachable or disposable balloons
• CPC Class Codes: A61M 2210/1078 : Urinary tract
• CPC Class Codes: A61M 2210/1085 : Bladder
• CPC Class Codes: A61M 25/00 : Catheters; Hollow probes dilators A61M29/00; peritoneal catheters A61M1/285; tracheal tubes A61M16/04; for drainage A61M27/00; for uterus, vagina or rectum A61M31/00 ; for measuring or testing A61B; materials for catheters A61L29/00
• CPC Class Codes: A61M 25/04 : in the body, e.g. expansible A61M25/10, A61M16/0488 take precedence
• CPC Class Codes: A61M 25/10 : Balloon catheters A61M25/0125 takes precedence; embolectomy A61B17/22032; retractors A61B17/02; inflatable balloons for placing stents or stent-grafts A61F2/958 ; stomach balloons for treatment of obesity A61F5/0003; oesophagal tubes A61J15/00
• CPC Class Codes: A61M 25/1002 : characterised by balloon shape A61M25/1006, A61M25/1009 take precedence
• CPC Class Codes: A61M 29/02 : Dilators made of swellable material balloon catheters for angioplasty A61M25/104

Abstract

An implant for use in a human or animal body can include a flexible housing with an outer wall and having a chamber therein. The implant can have at least one high vapor pressure medium within the chamber. The at one high vapor pressure medium can have a combined vapor pressure equal to or greater than about the average value of the hydrostatic pressure of the implantation site plus the skin tension of the housing minus the gas tension of the dissolved gasses present at the implantation site.

Claims

1. A device for use in a human or animal body, comprising:

a flexible housing comprising an outer wall and defining a chamber therein; and

at least one high vapor pressure medium having a vapor pressure greater than the pressure in an anatomical structure and a low permeability rate through the outer wall of less than 1 ml/day at body temperature.

2. A device as in claim 1, wherein said high vapor pressure media comprises at least one of heptafluoropropane, perfluorooctylbromide, perfluorohexane, perfluorodecalin, tetrafluoroethane, sulfur hexafluoride, hexafluoroethane, perfluoropropane, perfluorobutane, perfluoropentane, perfluoroheptane, perfluorooctane, octafluoropropane, decafluoro-n-butane and perfluoroperhydrophenanthrene.

3. A device as in claim 1, wherein said high vapor pressure medium is a liquid at body temperature.

4. A device as in claim 1, wherein said high vapor pressure medium has a solubility of less than about 0.1 ml per ml of urine at body temperature and pressure.

5. A device as in claim 1, wherein said housing is configured to be positioned within an anatomical structure while in a first, introduction configuration and then at least partially inflated into a second, implanted configuration.

6. A device as in claim 1, wherein said device is an inflatable attenuation device.

7. A device as in claim 1, wherein said device is an implantable pressure attenuation device.

8. A device as in claim 1, wherein the at least one high vapor pressure medium comprises a vapor and a reservoir of liquid.

9. A device as in claim 1, wherein the device is a device for attenuating and/or baffling transient pressure waves in relatively incompressible materials in organs in a human or animal body.

10. A device as in claim 1, wherein the device is adapted to reversibly occupying intraorgan space.

11. A device as in claim 1, wherein the outer wall is made of a gas permeable material that allows permeation of the at least one high vapor pressure medium at a rate of at least 15 ml per twelve months out of the device.

12. A device as in claim 1, wherein said anatomical structure is the bladder.

13. A device as in claim 1, further comprising a biodegradable component, wherein the biodegradable component comprises a drug.

14. A device as in claim 13, wherein the biodegradable component comprises a film.

16. A device as in claim 13, wherein the flexible wall housing comprises the biodegradable component.

17. A device as in claim 13, wherein the biodegradable component is within the chamber.

18. A device as in claim 13, wherein the biodegradable component further comprises a biodegradable polymer comprising at least one of an ester, an ether, and an amide.

21. A device as in claim 13, wherein the biodegradable component comprises a drug which is effective in the treatment of a condition affecting the bladder.

22. A method of treating a condition affecting the bladder comprising implanting a device into a human or animal body, said device comprising the device of claim 21.

23. A method as in claim 22, wherein the condition affecting the bladder comprises:

urinary incontinence, urinary tract cancer, an infection affecting the bladder, or an inflammatory, condition affecting the bladder.

24. A method as in claim 22, wherein the drug comprises at least one of:

a neurotoxin, acetaminophen, acetylsalicylic acid, cyclophosphamide, fentanyl citrate, antimuscarinic agents, atropine, Bacillus Calmette Guerin vaccine, botulinum toxin type A, calcium channel blockers, cisplatin, clenbuterol, codeine, cyproterone, darifenacin, desmopressin, diethylstilbestrol, dimethyl sulfoxide, doxorubicin, emepronium, estramustine, flavoxate, flufenisal, fluorouracil, flutamide, heparin, hyoscyamin, ibuprofen, imipramine, inaperisone, indomethacin, indoprofen, lanperisone, leuprolide, lidocaine hydrochloride, megestrol acetate, methotrexate, mitomycin, muscle relaxants, naproxen, NC-1800, norepinephrine uptake inhibitors, NS-21, oxybutynin, oxycodone, pentosanpolysulfate sodium, phenazopyridine hydrochloride, potassium channel openers, procaine hydrochloride, propantheline, propiverine, rociverine, salicyl alcohol, serotonin uptake inhibitors, S-oxybutynin, stilonium iodide, terodiline, tetracaine hydrochloride, thiotepa, tolterodine, trospium, vamicamide YM-46303, verapamil, vinblastine, ZD-6169, and β

-2 agonists.

25. The device of claim 1, wherein the outer wall of the flexible housing further comprises a visibility enhancement to improve its visibility within the bladder.

15. (canceled)

19. (canceled)

20. (canceled)

26-220. -220. (canceled)