VASCULAR BIFURCATION PROSTHESIS WITH AT LEAST ONE FROND

• US 20100222870A1
• Filed: 05/14/2010
• Published: 09/02/2010
• Est. Priority Date: 04/14/2003
• Status: Active Grant

• Current Assignee: Poseidon Medical Inc.
• Original Assignee: Tryton Medical, Inc.
• Inventors: Kaplan, Aaron V., Vargas, Jaime
• Granted Patent: US 8,257,432 B2
• Time in Patent Office: Days
• US Class Current: 623/1.350
• CPC Class Codes: A61F 2/852 Two or more distinct overlapping stents
• CPC Class Codes: A61F 2/856 Single tubular stent with a side portal passage
• CPC Class Codes: A61F 2/91 made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
• CPC Class Codes: A61F 2/915 with bands having a meander structure, adjacent bands being connected to each other
• CPC Class Codes: A61F 2/954 for placing stents or stent-grafts in a bifurcation
• CPC Class Codes: A61F 2/958 Inflatable balloons for placing stents or stent-grafts
• CPC Class Codes: A61F 2002/821 Ostial stents
• CPC Class Codes: A61F 2002/8486 provided on at least one of the ends
• CPC Class Codes: A61F 2002/91525 within the whole structure different bands showing different meander characteristics, e.g. frequency or amplitude
• CPC Class Codes: A61F 2002/91533 characterised by the phase between adjacent bands
• CPC Class Codes: A61F 2002/91575 connected peak to trough
• CPC Class Codes: A61F 2220/0016 with sharp anchoring protrusions, e.g. barbs, pins, spikes
• CPC Class Codes: A61F 2250/006 modular

Abstract

An embodiment of the invention provides a prosthesis for placement at an Os opening from a main body lumen to a branch body lumen. The prosthesis comprises a radially expansible support and at least one frond extending axially from an end of the support. The support is configured to be deployed in at least a portion of a first body lumen, which can be a branch body lumen. At least one frond is extendable into across an ostium, e.g., from the first body lumen into a second body lumen, which may be a main body lumen.

Claims

1. A prosthesis for placement at an ostium opening from a main body lumen to a branch body lumen, the prosthesis comprising:

a radially expansible support configured to be deployed in at least a portion of the branch body lumen or the main body lumen; and

a plurality of fronds extending axially from an end of the support, the fronds being configured to be positioned across the ostium and (a) into the main body lumen in a direction opposite to blood flow when the radially expansible support is in the branch body lumen or (b) into the branch body lumen in a direction of blood flow when the radially expansible support is in the main body lumen;

wherein the plurality of fronds have sufficient length to (1) extend into and bend and rotate and thereby expandably circumscribe at least partially the main vessel wall and reach the portion of the main vessel wall opposing the ostium when the support is implanted in the branch lumen, or (2) reach the portion of the branch vessel wall beyond the ostium when the support is implanted in the main lumen.

2. The prosthesis as in claim 1, wherein the plurality of fronds have an axial length which is at least about 1.5 times the width of the support prior to radial expansion.

3. The prosthesis as in claim 1, wherein the prosthesis is configured to be deployed such that a flow path is maintained in the main body lumen between the plurality of fronds and beyond the ostium opening.

4. The prosthesis as in claim 1, wherein the support is configured to be deployed completely within the branch lumen.

5. The prosthesis as in claim 1, further comprising at least one opening extending through a side wall of the prosthesis between at least two fronds and between the support and the proximal ends of the fronds such that a second prosthesis can be deployed within the passage through the at least one opening.

6. The prosthesis as in claim 1, wherein the plurality of fronds includes at least three fronds.

7. The prosthesis as in claim 1, wherein at least one of the fronds comprises a closed loop shape.

8. The prosthesis as in claim 1, wherein the fronds comprise a resilient metal.

9. The prosthesis as in claim 1, wherein at least one of the fronds is configured to be expandably deployed proximate a vessel wall by an expandable portion of a catheter.

10. The prosthesis as in claim 1, wherein the plurality of fronds includes alternatively varying long fronds and short fronds.

11. The prosthesis as in claim 10, wherein the short fronds have an axial length approximately half that of the long fronds.

12. The prosthesis as in claim 1, further comprising a first strut configured to increase at least one of a longitudinal or a torsional stiffness of at least one of the fronds.

13. The prosthesis as in claim 12, wherein the strut has a substantially triangular shape in the expanded state.

14. The prosthesis as in claim 12, further comprising a second expandable strut, the second strut having a curved shape in the expanded state.

15. The prosthesis as in claim 1, wherein the fronds are configured to function as a mechanical joining means to a prosthesis deployed in the main body lumen.

16. The prosthesis as in claim 15, wherein the fronds increase a positional stability of at least one of the prostheses deployed in the branch body lumen or a prosthesis deployed in the main body lumen.

17. The prosthesis as in claim 1, wherein the fronds are configured to improve a distribution of force on at least one of the main body lumen or a prosthesis deployed in the main body lumen.

18. The prosthesis as in claim 17, wherein the force is one of a radially compressive force or a radially expansive force.

19. The prosthesis as in claim 17, wherein the fronds improve the distribution of force over a length of at least one of the main body lumen or the prosthesis deployed in the main body lumen

20. The prosthesis as in claim 1, wherein the fronds are configured to be radially constrained against a portion of a delivery catheter used to deliver the prosthesis to opening of the branch body lumen.

21. The prosthesis as in claim 20, wherein the portion of the delivery catheter is one of an expandable member or an expandable balloon.

22. The prosthesis as in claim 20, wherein the fronds are configured to be releasably constrained by a means for constraining the fronds positioned over at least a portion of the fronds.

23. The prosthesis as in claim 22, wherein the fronds are configured to be slidably releasable from the constraining means.

24. The prosthesis as in claim 22, wherein the constraining means comprises a cuff.

25. The prosthesis as in claim 1, wherein at least a portion of the fronds comprises a lubricous coating.

26. The prosthesis as in claim 1, wherein at least a portion of the fronds comprises a drug coating.

27. The prosthesis as in claim 26, wherein the drug coating is a drug eluting coating.

28. The prosthesis as in claim 26, wherein the drug coating is configured to produce at least one of a controlled drug release rate, a constant drug release rate, bi-modal drug release rate or a controlled concentration of drug proximate a target vessel wall.

29. The prosthesis as in claim 26, wherein the drug is one of an anti-cell prolifertive, anti cell migration, anti-neo plastic, anti inflammatory drug.

30. The prosthesis as in claim 26, wherein the drug is configured to reduce an incidence or amount of restensosis.

31. The prosthesis as in claim 26, wherein the drug includes a first drug and second a drug.

32. The prosthesis as in claim 26, wherein the drug coating includes a first coating and a second coating.

33. The prosthesis as in claim 32, wherein the first coating is configured to produce a first drug release rate and the second coating is configured to produce a second drug release rate.

34. The prosthesis as in claim 1, wherein the fronds extend distally from the radially expansible support.

35. A prosthesis for placement at an ostium opening from a larger body lumen to a smaller body lumen, the prosthesis comprising:

a radially expansible support configured to be deployed in at least a portion of the smaller body lumen; and

a plurality of fronds extending axially from an end of the support, the fronds being configured to be positioned across the ostium and into the larger body, the fronds having sufficient length to be deformably deployed in at least a portion of the larger body lumen extending away from the ostium and to apply less radial force to adjacent tissue than the expanded support applies in the smaller body lumen.

36. A prosthesis for placement at an ostium opening from a first body lumen to a second body lumen across an ostium between the first and second body lumens, the prosthesis comprising:

a radially expansible support configured to be deployed in at least a portion of the first body lumen; and

at least one frond extending axially from an end of the support, the frond configured to be positioned across the ostium and into the second body lumen, the at least one frond having sufficient length to extend into and expandably circumscribe at least partially the second vessel wall and reach the portion of the second vessel wall across the ostium when the support is implanted in the first lumen.

37. The prosthesis as in claim 36, wherein the at least one frond is configured to extend helically.

38. The prosthesis as in claim 36, wherein the at least one frond is configured to extend spirally.

39. The prosthesis as in claim 36, wherein the at least one frond is configured to be disposed in an upstream or downstream direction in the second body lumen when deployed.

40. The prosthesis as in claim 39, wherein the at least one frond is configured to receive a second prosthesis such that when deployed the at least one frond is entrapped between the second vessel wall and the second prosthesis.

41. The prosthesis as in claim 36 comprising at least two fronds, the at least two fronds are configured to be disposed in an upstream or downstream direction in the second body lumen when deployed.