Prosthetic Devices

• US 20100222888A1
• Filed: 09/09/2008
• Published: 09/02/2010
• Est. Priority Date: 09/11/2007
• Status: Active Grant

• Current Assignee: Solvay Advanced Polymers LLC (Solvac SA)
• Original Assignee: Solvay Advanced Polymers LLC (Solvac SA)
• Inventors: Thomas, David B., Carter, Roy L., Schuler, Timothy, El-Hibri, Mohammad Jamal, Maljkovic, Nikica, Rushing, Todd S.
• Granted Patent: US 8,592,531 B2
• Time in Patent Office: Days
• US Class Current: 623/20.140
• CPC Class Codes: A61F 2/28 Bones joints A61F2/30
• CPC Class Codes: A61L 27/18 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
• CPC Class Codes: A61L 27/26 Mixtures of macromolecular compounds
• CPC Class Codes: A61L 27/34 Macromolecular materials
• CPC Class Codes: A61L 27/44 having a macromolecular matrix
• CPC Class Codes: A61L 27/446 with other specific inorganic fillers other than those covered by A61L27/443 or A61L27/46
• CPC Class Codes: C08G 2261/312 Non-condensed aromatic systems, e.g. benzene
• CPC Class Codes: C08L 65/02 Polyphenylenes
• CPC Class Codes: C08L 71/00 Compositions of polyethers obtained by reactions forming an ether link in the main chain of polyacetals C08L59/00; of epoxy resins C08L63/00; of polythioether-ethers C08L81/02; of polyether-sulfones C08L81/06; Compositions of derivatives of such polymers
• CPC Class Codes: C08L 71/12 Polyphenylene oxides
• CPC Class Codes: C08L 81/06 Polysulfones; Polyethersulfones

Abstract

A prosthetic device made of a first specific type of polyarylene, taken alone or in combination with a second specific type of polyarylene, featuring some unexpected advantages such as a very high strength and stiffness, good elongation properties, high chemical resistance, good biocompatibility as well as an outstanding impact resistance.

Claims

1. A prosthetic device comprising at least one part consisting of a material comprising at least one polyarylene (P2), of which the efficient arylene recurring units (R2) are a mix (M2) consisting of:

less than 70 mole % based on the total number of moles of efficient arylene recurring units (R2), of rigid rod-forming arylene units (Ra), said rigid rod-forming arylene units (Ra) being optionally substituted by at least one monovalent substituting group

with

more than 30 mole %, up to 90 mole %, based on the total number of moles of efficient arylene recurring units (R2), of kink-forming arylene units (Rb), said kink-forming arylene units being optionally substituted by at least one monovalent substituting group.

15. The prosthetic device according to claim 1, wherein the polyarylene (P2) is a kinked rigid-rod polyphenylene copolymer, essentially all the recurring units of which consist of a mix (M2) of p-phenylene substituted by a phenylketone group with unsubstituted m-phenylene in a mole ratio p-phenylene:

m-phenylene of from 35;

65 to 60;

40.

16. The prosthetic device according to claim 1, wherein essentially all the recurring units of the polyarylene (P2) are efficient arylene recurring units (R2).

17. The prosthetic device according to claim 1, which is suitable for replacing a missing or defective animal or human body part.

18. The prosthetic device according to claim 1, which is suitable for reinforcing or supplementing a defective body part.

19. The prosthetic device according to claim 1, which is an implantable orthopaedic prosthesis.

20. The prosthetic device according to claim 19, which is a knee prosthesis or a hip joint.

21. The prosthetic device according to claim 1, which is an implant.

2. (canceled)

4. (canceled)

8. (canceled)

9. (canceled)

11. (canceled)

14. A prosthetic device comprising at least one part consisting of a material comprising at least one polyarylene (P1) and at least one polyarylene (P2),

wherein the efficient arylene recurring units (R1) of the polyarylene (P1) are a mix (M1) consisting of:

at least 70 mole %, based on the total number of moles of efficient arylene recurring units (R1), of rigid rod-forming arylene units (Ra), said rigid rod-forming arylene units (Ra) being optionally substituted by at least one monovalent substituting group

with

from 5 to 30 mole %, based on the total number of moles of efficient arylene recurring units (R1), of kink-forming arylene units (Rb), said kink-forming arylene units being optionally substituted by at least one monovalent substituting group;

and wherein the efficient arylene recurring units (R2) of the polyarylene (P2) are a mix (M2) consisting of;

less than 70 mole %, based on the total number of moles of efficient arylene recurring units (R2), of rigid rod-forming arylene units (Ra), said rigid rod-forming arylene units (Ra) being optionally substituted by at least one monovalent substituting group

with

more than 30 mole %, up to 90 mole %, based on the total number of moles of efficient arylene recurring units (R2), of kink-forming arylene units (Rb), said kink-forming arylene units being optionally substituted by at least one monovalent substituting group.

3. The prosthetic device according to claim 14, wherein the polyarylene (P1) is a kinked rigid-rod polyphenylene copolymer, essentially all, the recurring units of which consist of a mix (M1) of p-phenylene substituted by a phenylketone group with unsubstituted m-phenylene in a mole ratio p-phenylene:

m-phenylene of from 79;

21 to 95;

5 and wherein the polyarylene (P2) is a kinked rigid-rod polyphenylene copolymer, essentially all the recurring units of which consist of a mix (M2) of p-phenylene substituted by a phenylketone group with unsubstituted m-phenylene of in a mole ration p-phenylene;

m-phenylene if from 35;

65 to 60;

40.

5. The prosthetic device according to claim 14, wherein essentially all the recurring units of the polyarylene (P2) are efficient arylene recurring units (R2).

6. The prosthetic device according to claim 14, wherein the weight of the polyarylene (P2), based on the combined weight of the polyarylene (P1) and the polyarylene (P2), is of at least 5% and at most 95%.

7. The prosthetic device according to claim 14, wherein the weight of the polyarylene (P2), based on the combined weight of the polyarylene (P1) and the polyarylene (P2), is of at least 40% and at most 85%.

10. The prosthetic device according to claim 14, wherein the weight of the polyarylene (P2), based on the combined weight of the polyarylene (P1) and the polyarylene (P2), ranges from 40 to 65%.

12. The prosthetic device according to claim 14, wherein the combined weight of the polyarylene (P1) and of the polyarylene (P2), based on the total weight of the material, is above 80%.

13. The prosthetic device according to claim 14, wherein said material consists essentially of the polyarylene (P1) and the polyarylene (P2).

22. A surgical method, which involves implanting a prosthetic device in the body of an animal or a human, wherein said prosthetic device comprises at least one part consisting of a material comprising at least one polyarylene (P2), of which the efficient arylene recurring units (R2) are a mix (M2) consisting of:

less than 70 mole %, based on the total number of moles of efficient arylene recurring units (R2), of rigid rod-forming arylene units (Ra), said rigid rod-forming arylene units (Ra) being optionally substituted by at least one monovalent substituting group

with

more than 30 mole %, up to 90 mole %, based on the total number of moles of efficient arylene recurring units (R2), of kink-forming arylene units (Rb), said kink-forming arylene units being optionally substituted by at least one monovalent substituting group.

23. The surgical method according to claim 22, wherein the prosthetic device is implanted in the body of a patient.

24. The surgical method according to claim 22, wherein the prosthetic device is a cosmetic implant.

25. The surgical method according to claim 22, wherein the material further comprises at least one polyarylene (P1), of which the efficient arylene recurring units (R1) are a mix (M1) consisting of:

at least 70 mole %, based on the total number of moles of efficient arylene recurring units (R1), of rigid rod-forming arylene units (Ra), said rigid rod-forming arylene units (Ra) being optionally substituted by at least one monovalent substituting group

with

from 5 to 30 mole %, based on the total number of moles of efficient arylene recurring units (R1), of kink-forming arylene units (Rb), said kink-forming arylene units being optionally substituted by at least one monovalent substituting group.