Screening system and method for analyzing a plurality of biosensors
First Claim
1. A screening system capable of controlling a movement and/or storage of a sensor carrier therein to ensure there is a substantially constant temperature gradient present across at least a portion of the sensor carrier.
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Accused Products
Abstract
A screening device and a method are described herein which can automatically handle and measure (interrogate) a plurality of sensor carriers (i.e., multiwell plates, microplates) with multi-dimensionally arranged, temperature-compensated or temperature-compensatable optical sensors, while maintaining a substantially constant temperature gradient for a relatively long period of time around the optical sensors where temperature compensation has been performed on the sensor carriers.
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Citations
31 Claims
- 1. A screening system capable of controlling a movement and/or storage of a sensor carrier therein to ensure there is a substantially constant temperature gradient present across at least a portion of the sensor carrier.
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5. A screening system, comprising:
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a temperature equilibration system which includes a temperature compensation body on which a sensor carrier is stored for a predetermined amount of time to ensure there is a substantially constant temperature gradient across at least a portion of the sensor carrier; and a measurement system which interrogates one or more sensors located within the sensor carrier when there is still the substantially constant temperature gradient present across at least a portion of the sensor carrier - View Dependent Claims (6, 7)
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8. A screening system comprising:
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a measurement chamber; a take in/out mechanism which receives a sensor carrier and moves the sensor carrier to inside said measurement chamber, said measurement chamber contains at least the following; a handling system; a temperature equilibration system which has a plate holder with one or more layers where each of the layers has a plurality of temperature compensation bodies; a table which has a measurement nest; wherein said handling system takes the sensor carrier from said take in/out mechanism and places the sensor carrier onto one of the temperature compensation bodies to help equalize a temperature of the sensor carrier; and wherein said handling system after a period of time takes the sensor carrier from the one temperature compensation body of said temperature equilibration system and places the sensor carrier into the measurement nest of said table; a measurement system which interrogates one or more sensors located within the sensor carrier when the sensor carrier is located on the measurement nest of the table; and a control unit for controlling said take in/out mechanism, said handling system, said temperature equilibration system, said table and said measurement system to perform a measurement analyzes on the sensors located within the sensor carrier. - View Dependent Claims (9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21)
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22. A method for performing a label-free assay on a sensor carrier within a screening system, said method comprising the steps of:
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receiving the sensor carrier; placing the sensor carrier onto one of a plurality of temperature compensation bodies which are located on one or more layers of a plate holder which is part of a temperature equilibration system, wherein each temperature compensation body has a bottom which is configured to match a bottom of the sensor carrier and is also configured to not damage the sensors in the sensor carrier; moving the sensor carrier from the temperature compensation body located within the temperature equilibration system to a measurement nest on a table; and interrogating one or more sensors in the sensor carrier while the sensor carrier is located on the measurement nest of said table. - View Dependent Claims (23, 24, 25, 26, 27, 28, 29, 30, 31)
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Specification