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CONTROLLED-RELEASE OPHTHALMIC VEHICLES

  • US 20100226997A1
  • Filed: 03/05/2009
  • Published: 09/09/2010
  • Est. Priority Date: 03/05/2009
  • Status: Active Grant
First Claim
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1. An ophthalmically acceptable vehicle, comprising:

  • an aqueous suspension having a first viscosity, said suspension comprising from about 0.1% to about 6.5% by weight, based on the total weight of the suspension, of a carboxyl-containing polymer prepared by polymerizing one or more carboxyl-containing monoethylenically unsaturated monomers and less than about 5% by weight of a cross-linking agent, said weight percentages of monomers being based on the total weight of monomers polymerized, said carboxyl-containing polymer having average particle size of not more than about 50 μ

    m in equivalent spherical diameter, anda sufficient amount of a second polymer allowing said carboxyl-containing polymer to remain suspended,wherein upon contact with tear fluid, said vehicle gels to a second viscosity which is greater than the first viscosity.

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