METHODS FOR PROCESSING SUBSTRATES HAVING AN ANTIMICROBIAL COATING

• US 20100227052A1
• Filed: 03/09/2009
• Published: 09/09/2010
• Est. Priority Date: 03/09/2009
• Status: Abandoned Application

• Current Assignee: Baxter Healthcare SA (Baxter International Inc.), Baxter International Inc.
• Original Assignee: Baxter Healthcare SA (Baxter International Inc.), Baxter International Inc.
• Inventors: Carter, Phillip W., Green, John-Bruce D.
• Application Number:
  US12/400,439
• Publication Number:
  US 20100227052A1
• Time in Patent Office: Days
• US Class Current: 427/161
• CPC Class Codes: A01N 2300/00 Combinations or mixtures of active ingredients covered by classes A01N27/00 - A01N65/48 with other active or formulation relevant ingredients, e.g. specific carrier materials or surfactants, covered by classes A01N25/00 - A01N65/48
• CPC Class Codes: A01N 25/10 Macromolecular compounds
• CPC Class Codes: A01N 25/34 Shaped forms, e.g. sheets, not provided for in any other sub-group of this main group
• CPC Class Codes: A01N 59/16 Heavy metals; Compounds thereof
• CPC Class Codes: A01N 59/20 Copper
• CPC Class Codes: A61L 27/306 Other specific inorganic materials not covered by A61L27/303 - A61L27/32
• CPC Class Codes: A61L 29/106 Inorganic materials other than carbon
• CPC Class Codes: A61L 31/088 Other specific inorganic materials not covered by A61L31/084 or A61L31/086
• CPC Class Codes: B82Y 30/00 Nanotechnology for materials or surface science, e.g. nanocomposites
• CPC Class Codes: C23C 8/08 only one element being applied
• CPC Class Codes: Y10T 428/269 including synthetic resin or polymer layer or component
• CPC Class Codes: Y10T 428/31681 Next to polyester, polyamide or polyimide [e.g., alkyd, glue, or nylon, etc.]
• CPC Class Codes: Y10T 428/31696 Including polyene monomers [e.g., butadiene, etc.]
• CPC Class Codes: Y10T 428/31699 Ester, halide or nitrile of addition polymer

Abstract

Methods for processing substrate surfaces carrying coatings comprising a metal are disclosed. The methods involve providing a substrate surface having a coating comprising a metal, and exposing the substrate surface to a halogen-containing gas.

Claims

1. A method for processing a substrate having a coating comprising a metal comprising:

providing a substrate surface having a coating comprising a metal, and exposing the substrate surface to a halogen-containing gas.

2. The method of claim 1, wherein the substrate surface comprises at least one plastic, glass, metal, ceramic, elastomer, or mixtures or laminates thereof.

3. The method of claim 1, wherein the substrate surface comprises a plastic or elastomer selected from the group consisting of:

acrylonitrile butadiene styrenes, polyacrylonitriles, polyamides, polycarbonates, polyesters, polyetheretherketones, polyetherimides, polyethylenes, polyethylene terephthalates, polylactic acids, polymethyl methyacrylates, polypropylenes, polystyrenes, polyurethanes, poly(vinyl chlorides), polyvinylidene chlorides, polyethers, polysulfones, silicones, natural rubbers, synthetic rubbers, styrene butadiene rubbers, ethylene propylene diene monomer rubbers, polychloroprene rubbers, acrylonitrile butadiene rubbers, chlorosulphonated polyethylene rubbers, polyisoprene rubbers, isobutylene-isoprene copolymeric rubbers, chlorinated isobutylene-isoprene copolymeric rubbers, brominated isobutylene-isoprene copolymeric rubbers, and blends and copolymers thereof.

4. The method of claim 1, wherein the substrate surface comprises a surface of a medical device or medical device component.

5. The method of claim 1, wherein the substrate surface comprises a surface of a medical fluid container or medical fluid flow system.

6. The method of claim 1, wherein the substrate surface comprises a surface of an I.V. set.

7. The method of claim 1, wherein the substrate surface comprises a surface of a medical device or medical device component selected from the group consisting of:

I.V. tubing, I.V. fluid bags, access devices for I.V. sets, septa, stopcocks, I.V. set connectors, I.V. set adaptors, clamps, I.V. filters, catheters, needles, and cannulae.

8. The method of claim 1, wherein the substrate surface comprises a surface of a luer access device or a needleless luer access device.

9. The method of claim 1, wherein the substrate surface comprises an antimicrobial metal coating.

10. The method of claim 1, wherein the metal comprises silver, copper, gold, zinc, cerium, platinum, palladium, tin, or mixtures thereof.

11. The method of claim 1, wherein the metal comprises silver.

12. The method of claim 1, wherein the metal comprises metallic nanoparticles.

13. The method of claim 12, wherein the metallic nanoparticles have an initial diameter of about 1 nm to about 1000 nanometers.

14. The method of claim 1, wherein the exposing occurs for about 1 second to about 24 hours.

15. The method of claim 1, wherein the halogen-containing gas is selected from the group consisting of:

fluorine gas, chlorine gas, bromine gas, interhalogen gases, halogen oxide gases, and mixtures thereof.

16. The method of claim 1, wherein the halogen-containing gas is an interhalogen gas or a halogen oxide gas selected from the group consisting of chlorine monofluoride, chlorine trifluoride, chlorine pentafluoride, bromine monofluoride, bromine trifluoride, bromine pentafluoride, bromine monochloride, iodine monofluoride, iodine trifluoride, iodine pentafluoride, iodine heptafluoride, iodine monochloride, iodine trichloride, iodine monobromide, oxygen difluoride, dioxygen difluoride, chlorine oxide, dichloride oxide, chlorine dioxide, dichlorine hexoxide, dichlorine heptoxide, bromine oxide, bromine dioxide, and dibromine oxide.

17. The method of claim 1, wherein the exposing is carried out at a gas pressure of about 10⁻

4 torr to about 7600 torr.

18. The method of claim 1, wherein the exposing is carried out at a temperature of about 25°

C. to about 100°

C.

19. The method of claim 1, wherein the coating prior to said exposing has a first metal content, the coating after said exposing has a second metal content, and the second metal content is at least 40% of the first metal content.

20. The method of claim 1, wherein the coating prior to said exposing has a first halide content, the coating after said exposing has a second halide content, and the second halide content is increased compared to the first halide content.

21. The method of claim 1, wherein the substrate surface having the coating comprising a metal is initially opaque and is rendered substantially translucent after exposure to the halogen-containing gas.