INFORMATION ACQUISITION METHOD, INFORMATION ACQUISITION APPARATUS AND DISEASE DIAGNOSIS METHOD

• US 20100227308A1
• Filed: 02/24/2010
• Published: 09/09/2010
• Est. Priority Date: 07/02/2003
• Status: Active Grant

• Current Assignee: Canon Kabushiki Kaisha (Canon Inc.)
• Original Assignee: Canon Kabushiki Kaisha (Canon Inc.)
• Inventors: Ban, Kazuhiro, Okamoto, Tadashi, Kobayashi, Shin, Nakamura, Kumi, Kuge, Katsuaki, Hashimoto, Hiroyuki, Komatsu, Manabu, Imamura, Takeshi
• Granted Patent: US 8,436,535 B2
• Time in Patent Office: Days
• US Class Current: 435/4
• CPC Class Codes: G01N 33/4833 of solid biological material, e.g. tissue samples, cell cultures tissue in vivo A61B5/00; cell suspensions G01N33/48735
• CPC Class Codes: G01N 33/6848 Methods of protein analysis involving mass spectrometry

Abstract

An information acquisition method for acquiring information on a target object, that includes a step of promoting ionization of the target object using a substance for promoting ionization of the target object to cause the target object to emit, and a step of acquiring information on the mass of the flew target object using time-of-flight secondary ion mass spectrometry.

Claims

1-37. -37. (canceled)

38. A method for acquiring information on a target object, comprising the steps of:

applying a substance to an object containing the target object to decompose the object specifically and to prepare the target object;

irradiating the object containing the target object with an ion beam to ionize the target object after applying the substance; and

acquiring information on the mass of the target object that ionizes using time-of-flight secondary ion mass spectrometry after irradiating the object,

wherein the substance promotes ionization of the target object.

39. The method according to claim 38, wherein the substance is a digestive enzyme.

40. The method according to claim 38, wherein the target object is any of:

a protein;

a peptide;

or a metabolite.