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Compact disk based system for separating immunomagnetic bead labeledparticulates and method thereof

  • US 20100227379A1
  • Filed: 06/25/2009
  • Published: 09/09/2010
  • Est. Priority Date: 03/03/2009
  • Status: Active Grant
First Claim
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1. A disk based system for separating at least two types of particulates, which are respectively labeled and not labeled with immunomagnetic beads, contained in a sample fluid, the system comprising:

  • a disk-like carrier board, which has a geometric center and an outer circumferential rim, the disk-like carrier board forming at least one flow channel structure, each flow channel structure comprising;

    an inner reservoir, which is arranged adjacent to the geometric center of the disk-like carrier board for receiving the sample fluid,at least one separation chamber, which is arranged adjacent to the inner reservoir and is in fluid communication with the inner reservoir through at least one micro flow channel, andat least one outer reservoir, which is arranged between the outer circumferential rim of the disk-like carrier board and the separation chamber and is in fluid communication with the separation chamber through at least one micro flow channel; and

    a magnetic attraction unit, which is arranged atop the disk-like carrier board and adjacent to the inner reservoir and the separation chamber to generate a magnetic force that has a predetermined distribution of intensity and covers the inner reservoir and the separation chamber;

    wherein when the disk-like carrier board spins, the sample fluid is caused by a centrifugal force induced by the spinning of the disk-like carrier board to flow from the inner reservoir through the micro flow channels to the outer reservoir whereby the immunomagnetic bead labeled particulates, when passing through the separation chamber, are attracted by the magnetic force generated by the magnetic attraction unit to thereby remain in the separation chamber, and the non-labeled particulates entrain the sample fluid to flow from the inner reservoir through the micro flow channels to the outer reservoir.

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