NEW CAMPTOTHECIN DERIVATIVES AND USES THEREOF
First Claim
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1. A compound which is represented by Formula I or a pharmaceutically acceptable salt thereof.
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Abstract
The present invention provides two new camptothecin derivatives, which were identified as S,R- and S,S-topotecan lactates, respectively. Both compounds have anticancer activities. Pharmaceutical compositions of the new camptothecin derivatives, and cancer therapies with the new camptothecin derivatives or their pharmaceutical compositions were also provided.
4 Citations
6 Claims
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1. A compound which is represented by Formula I
or a pharmaceutically acceptable salt thereof.
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2. The compound of claim 1, which is represented by Formula II
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3. The compound of claim 1, which is represented by Formula III
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4. A pharmaceutical composition comprising a compound according to claim 1 or a pharmaceutically acceptable salt thereof together with a pharmaceutically acceptable carrier.
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5. A pharmaceutical composition comprising a compound according to claim 2 or a pharmaceutically acceptable salt thereof together with a pharmaceutically acceptable carrier.
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6. A pharmaceutical composition comprising a compound according to claim 3 or a pharmaceutically acceptable salt thereof together with a pharmaceutically acceptable carrier.
Specification