DEVICE, SYSTEM AND METHOD FOR INTERACTING WITH A CELL OR TISSUE IN A BODY

• US 20100228082A1
• Filed: 04/12/2007
• Published: 09/09/2010
• Est. Priority Date: 08/07/2006
• Status: Abandoned Application

• Current Assignee: Koninklijke Philips Electronics N.V. (Koninklijke Philips N.V.)
• Original Assignee: Koninklijke Philips Electronics N.V. (Koninklijke Philips N.V.)
• Inventors: Den Toonder, Jacob Marinus Jan, Shimizu, Jeff, Dijksman, Johan Frederik, Pierik, Anke, Kuiper, Stein, Hendriks, Bernardus Hendrikus Wilhelmus, Rensen, Judith Margreet, Zou, Hans, Suijver, Jan Frederik
• Application Number:
  US12/376,460
• Publication Number:
  US 20100228082A1
• Time in Patent Office: Days
• US Class Current: 600/104
• CPC Class Codes: A61B 1/041 Capsule endoscopes for imaging
• CPC Class Codes: A61B 5/0031 Implanted circuitry
• CPC Class Codes: A61B 5/073 Intestinal transmitters
• CPC Class Codes: A61B 5/4839 combined with drug delivery
• CPC Class Codes: A61B 5/6882 Anchoring means

Abstract

A device or support, system and method are provided for precisely targeted and/or highly controlled interaction with a targeted cell or tissue in a body, with the support providing an ergonomic connecting interface for selectively connecting the support to a cell or tissue with at least minimal adverse affect to such cell or tissue, the system providing a remote facility that may be operatively associated with the support, and the method providing steps for employing the support and/or system so as to, inter alia, improve treatment, diagnostic and/or monitoring techniques and increase sensitivity and specificity with respect to interacting with, for example, diseased or abnormal cells or tissue without adversely effecting surrounding healthy cells or tissue, and/or the body in general.

Claims

1. A support comprising:

at least one ergonomic connecting interface for selectively connecting the support to a cell or tissue in a body;

at least one module suitable for accomplishing one or more operations relative to the cell or tissue; and

a controller operatively associated with an ergonomic connecting interface and/or a module.

2. The support of claim 1, wherein a module includes at least of one or more reservoirs suitable for retaining at least one substance, with at least one delivery mechanism associated therewith for selectively delivering one or more substances, one or more imagers suitable for imaging the cell or tissue, one or more sensors suitable for detecting various characteristics or pathology directly or indirectly associated with the cell or tissue, and one or more illuminators for providing light to or about the cell or tissue.

3. The support of claim 1, wherein the support is ingestible.

4. The support of claim 1, wherein the controller is operatively associated with the module so as to control the selective actuation thereof.

5. The support of claim 4, wherein the controller is operatively associated with the connecting interface so as to control the selective actuation thereof.

6. The support of claim 4, wherein the controller includes at least one sensor that operates, at least in part, to signal a controlled delivery of one or more medicaments.

7. The support of claim 4, wherein the controller includes a communicator for communicating with at least one remote facility.

8. The support of claim 5, wherein the controller includes a communicator for communicating with at least one remote facility.

9. The support of claim 5, further comprising a delivery mechanism for the controlled delivery of one or more substances.

10. The support of claim 7, wherein the remote facility includes a processing device for signaling the controlled delivery of one or more substances.

11. The support of claim 1, wherein the connecting interface includes at least one of (i) a microstructure and/or nano-element arrangement, (ii) an adhesive layer arrangement, and (iii) a suction system.

12. The support of claim 11, wherein the microstructure and/or nano-element arrangement includes an array of nano-pillars based on MEMS.

13. The support of claim 11, wherein the microstructure and/or nano-element arrangement includes one or more electro-statically actuated micro-hooks.

14. The support of claim 11, wherein an adhesive layer is pH activated.

15. The support of claim 11, wherein an adhesive layer changes from a first state to a second state when an electric field is applied thereto.

16. The support of claim 15, wherein the first state facilitates connecting to a cell or tissue in a body while the second state facilitates release therefrom.

17. The support of claim 11, wherein suction system includes one or more suction elements that cooperate with a targeted cell or tissue to define an adjustable chamber.

18. A system comprising:

at least one support suitable for being internalized into a body;

at least one ergonomic connecting interface operatively associated with each support;

at least one module operatively associated with each support, each module being suitable for accomplishing one or more operations relative to a cell or tissue in a body;

a controller operatively associated with at least one module; and

a remote facility operatively associated with the controller.

19. The system of claim 18, wherein a connecting interface includes at least one of (i) at least one nano-pillar array, (ii) at least one electro-statically actuated element, (iii) at least one polymer adhesive layer, and (iv) a suction system.

20. A method comprising the steps of:

introducing at least one support to one or more areas in a body;

connecting at least one support to a targeted cell or tissue of the body;

performing, via at least one support, at least one operation relative to the cell or tissue; and

disconnecting the at least one support in response to an event.

21. The method of claim 20, wherein the event includes at least one of:

(i) performance of an operation, (ii) elapse of a predetermined time amount, (iii) exhaustion of a predetermined resource amount, (iv) detection of an adverse reaction relative to the cell or tissue, and (v) a signal provided internal to or external from a support, such signal being either automatically or manually generated via a sensor and/or a remote facility.