METHODS AND DEVICES FOR TREATMENT OF LUMENAL SYSTEMS

• US 20100228280A1
• Filed: 03/09/2009
• Published: 09/09/2010
• Est. Priority Date: 03/09/2009
• Status: Abandoned Application

• Current Assignee: Adam Groothuis, Edward I. McNamara, Elazer R. Edelman, Peter Markham
• Original Assignee: Adam Groothuis, Edward I. McNamara, Elazer R. Edelman, Peter Markham
• Inventors: Edelman, Elazer R., Markham, Peter, Groothuis, Adam, McNamara, Edward I.
• Application Number:
  US12/400,041
• Publication Number:
  US 20100228280A1
• Time in Patent Office: Days
• US Class Current: 606/200
• CPC Class Codes: A61F 2/012 Multiple filtering units
• CPC Class Codes: A61F 2002/018 made from tubes or sheets of material, e.g. by etching or laser-cutting
• CPC Class Codes: A61F 2230/0006 circular
• CPC Class Codes: A61F 2230/0067 conical
• CPC Class Codes: A61F 2230/0069 cylindrical
• CPC Class Codes: A61F 2230/0078 hyperboloidal
• CPC Class Codes: A61M 2025/0096 being laterally outward extensions or tools, e.g. hooks or fibres
• CPC Class Codes: A61M 2025/109 having balloons for removing solid matters, e.g. by grasping or scraping plaque, thrombus or other matters that obstruct the flow
• CPC Class Codes: A61M 2025/1093 having particular tip characteristics
• CPC Class Codes: A61M 25/0074 Dynamic characteristics of the catheter tip, e.g. openable, closable, expandable or deformable
• CPC Class Codes: A61M 25/0082 Catheter tip comprising a tool
• CPC Class Codes: A61M 25/1011 Multiple balloon catheters
• CPC Class Codes: A61M 25/104 used for angioplasty

Abstract

The invention provides a variety of catheters and methods for using such catheters. An exemplary catheter includes an elongate body having a proximal end a distal end. The elongate body defines a longitudinal axis of the catheter. The exemplary catheter further includes at least one inflatable member disposed on the elongate body proximate the distal end of the elongate body. The interior of the inflatable member is in fluid communication with an inflation lumen in the elongate body. The exemplary catheter also includes a first filter adapted and configured to capture emboli in a patient'"'"'s bloodstream as the bloodstream passes through the first filter along a first direction. The exemplary catheter further includes a second filter adapted and configured to capture emboli in a patient'"'"'s bloodstream as the bloodstream passes through the second filter along a second direction, wherein the second direction is generally opposite to the first direction.

Claims

1. A catheter comprising:

a) an elongate body having a proximal end a distal end, the elongate body defining a longitudinal axis of the catheter;

b) at least one inflatable member disposed on the elongate body proximate the distal end of the elongate body, the interior of the inflatable member being in fluid communication with an inflation lumen in the elongate body;

c) a first filter disposed on the elongate body at a location proximal to the at least one inflatable member, the first filter being adapted and configured to capture emboli in a patient'"'"'s bloodstream as the bloodstream passes through the first filter along a first direction; and

d) a second filter disposed on the elongate body at a location proximal to the at least one inflatable member and distal to the first filter, the second filter being adapted and configured to capture emboli in a patient'"'"'s bloodstream as the bloodstream passes through the second filter along a second direction, wherein the second direction is generally opposite to the first direction.

2. The catheter of claim 1, wherein the second filter is adapted and configured to expand and contract along a direction generally transverse to the longitudinal axis of the catheter.

3. The catheter of claim 2, wherein the second filter is adapted and configured to expand and contract in response to a change in direction of a patient'"'"'s bloodflow.

4. The catheter of claim 2, wherein the second filter is adapted and configured to expand and contract in response to a change in a patient'"'"'s local blood pressure.

5. The catheter of claim 4, wherein the second filter is adapted and configured to adjust in size in response to local pressure gradients in a patient'"'"'s bloodstream.

6. The catheter of claim 2, wherein the second filter is adapted and configured to selectively expand and contract.

7. The catheter of claim 1, wherein the second filter is at least partially disposed within the first filter.

8. The catheter of claim 1, wherein the first filter and second filter can be adjusted in size.

9. The catheter of claim 1, wherein the first filter and second filter include radiopaque material.

10. The catheter of claim 1, wherein the first filter and second filter are adapted and configured to be displaced along the longitudinal axis with respect to the at least one inflatable member.

11. The catheter of claim 10, wherein the first filter and second filter are attached to a tubular member that is adapted and configured to receive the elongate body through a lumen defined by the tubular member.

12. The catheter of claim 1, wherein the at least one inflatable member has an undulating exterior surface defining at least one longitudinal channel therein sufficient to permit perfusion in a patient'"'"'s blood vessel when the at least one inflatable member is expanded.

13. The catheter of claim 1, wherein the catheter includes a plurality of inflatable members that cooperate to define at least one perfusion channel on the exterior of the catheter when the inflatable members are inflated.

14. The catheter of claim 13, wherein the plurality of inflatable members are adapted and configured to close and open the perfusion channel.

15. The catheter of claim 1, wherein the catheter includes a plurality of inflatable members that can be selectively expanded serially or in parallel.

16. The catheter of claim 1, wherein the at least one inflatable member includes polymeric material.

17. The catheter of claim 16, wherein the polymeric material includes polyester.

18. The catheter of claim 16, wherein the polymeric material includes at least one material selected from the group consisting of nylon, polyether block amide, and polyethylene.

19. The catheter of claim 1, wherein the distance between the at least one inflatable member and the second filter is substantially the same as the distance between a patient'"'"'s aortic valve and the location of the entrance to a patient'"'"'s coronary sinus.

20. The catheter of claim 1, wherein the distance between the at least one inflatable member and the second filter is adjustable.

21. The catheter of claim 1, wherein the catheter further comprises means for ejecting pressurized liquid proximate the distal end of the catheter.

22. The catheter of claim 21, wherein the means for ejecting liquid includes a plurality of openings in the exterior surface of the catheter in fluid communication with a source of pressurized fluid.

23. The catheter of claim 21, wherein the means for ejecting liquid is adapted and configured to eject liquid in a direction generally transverse to the longitudinal axis.

24. The catheter of claim 21, wherein the means for ejecting liquid includes a plurality of openings on the surface of the inflatable member.

25. The catheter of claim 24, wherein the openings on the surface of the inflatable member are in fluid communication with a source of pressurized fluid that is not in fluid communication with fluid used to inflate the at least one inflatable member.

47. The catheter of claim 11, wherein the first filter and second filter can be moved closer to or further away from each other along the axis of the catheter.

26. A catheter comprising:

a) an elongate body having a proximal end a distal end, the elongate body defining a longitudinal axis of the catheter;

b) a first filter disposed on the elongate body at a location proximal to the distal end, the first filter being adapted and configured to capture emboli in a patient'"'"'s bloodstream as the bloodstream passes through the first filter along a first direction; and

c) a second filter disposed on the elongate body at a location proximal to the distal end and distal to the first filter, the second filter being adapted and configured to capture debris in a patient'"'"'s bloodstream as the bloodstream passes through the second filter along a second direction, wherein the second direction is generally opposite to the first direction.

27. The catheter of claim 26, further comprising at least one inflatable member disposed on the elongate body proximate the distal end of the elongate body, the interior of the inflatable member being in fluid communication with an inflation lumen in the elongate body.

28. The catheter of claim 26, further comprising at least one deliverable prosthesis disposed on the elongate body proximate the distal end of the elongate body, the interior of the inflatable member being in fluid communication with an inflation lumen in the elongate body.

29. The catheter of claim 26, further comprising a removable sheath surrounding at least one of the first filter and second filter.

30. The catheter of claim 29, wherein the sheath surrounds the first filter and second filter.

31. The catheter of claim 30, wherein the second filter is disposed at least partially within the first filter.

32. The catheter of claim 30, wherein the catheter is adapted and configured for a neuro thrombectomy procedure.

46. The method of claim 32, wherein the ejecting step includes directing pressurized liquid through a plurality of openings disposed on the surface of the inflatable member.

33. A method of treating a patient'"'"'s luminal system, comprising:

a) providing a catheter including;

i) an elongate body having a proximal end a distal end, the elongate body defining a longitudinal axis of the catheter;

ii) at least one inflatable member disposed on the elongate body proximate the distal end of the elongate body;

iii) a first filter disposed on the elongate body at a location proximal to the at least one inflatable member, the first filter being adapted and configured to capture emboli in a patient'"'"'s bloodstream as the bloodstream passes through the first filter along a first direction; and

iv) a second filter disposed on the elongate body at a location proximal to the at least one inflatable member and distal to the first filter, the second filter being adapted and configured to capture emboli in a patient'"'"'s bloodstream as the bloodstream passes through the second filter along a second direction, wherein the second direction is generally opposite to the first direction;

b) disposing the distal end of the catheter in a patient'"'"'s luminal system; and

c) expanding the at least one inflatable member.

34. The method of claim 33, wherein the distal end of the catheter is disposed proximate a valve in the patient'"'"'s luminal system.

35. The method of claim 34, wherein the valve is the patient'"'"'s aortic valve.

36. The method of claim 34, further comprising:

a) disposing the first filter at a location downstream from the patient'"'"'s aortic root to capture emboli; and

b) expanding the second filter to prevent the emboli from being directed into the patient'"'"'s coronary sinus arteries.

37. The method of claim 36, wherein the second filter is expanded and contracted in response to a change in direction of a patient'"'"'s bloodflow.

38. The method of claim 36, wherein the second filter is expanded and contracted in response to a change in a patient'"'"'s local blood pressure.

39. The method of claim 37, wherein the second filter adjusts in size in response to local pressure gradients in a patient'"'"'s bloodstream.

40. The method of claim 36, wherein the second filter is selectively expanded and contracted.

41. The method of claim 35, further comprising disposing the second filter at least partially within the first filter.

42. The method of claim 33, further comprising displacing the filters along the longitudinal axis with respect to the inflatable member.

43. The catheter of claim 33 further comprising defining a perfusion channel proximate the exterior of the inflatable member.

44. The method of claim 33, further comprising ejecting pressurized liquid proximate the distal end of the catheter to remove debris from the valve area.

45. The method of claim 44, wherein liquid is directed through at least one of the valve leaflets to loosen debris from one or more of the valve leaflets.