SYSTEMS AND METHODS FOR AUTONOMIC NERVE MODULATION
First Claim
1. A system for modulating autonomic neural activity in a body having a spinal cord, a subclavian vein and thoracic lymphatic vessels that include a thoracic duct and a right lymphatic duct, the system comprising:
- at least one stimulation lead including at least a first electrode region and a second electrode region, the at least one stimulation lead being adapted to be fed through the subclavian vein into a desired thoracic lymphatic vessel to operationally position the first electrode region in the thoracic lymphatic vessel to stimulate sympathetic nerves branching from a first region of the spinal cord and to operationally position the second electrode region in the desired thoracic lymphatic vessel to stimulate sympathetic nerves branching from a second region of the spinal cord or stimulate parasympathetic nerves anatomically adjacent to the desired thoracic lymphatic vessel; and
a programmable neural stimulator programmed to deliver neural stimulation pulses to the first electrode region to modulate sympathetic activity in the sympathetic nerves branching from the first region of the spinal cord and to deliver neural stimulation pulses to the second electrode region to modulate sympathetic activity in the sympathetic nerves branching from the second region of the spinal cord or to modulate parasympathetic activity in the parasympathetic nerves anatomically adjacent to the desired thoracic lymphatic vessel.
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Accused Products
Abstract
According to various embodiments of a method for modulating autonomic neural activity in a body having a spinal cord, a subclavian vein and thoracic lymphatic vessels that include a thoracic duct and a right lymphatic duct, at least one programmed therapy is implemented using an implanted medical device to modulate autonomic neural activity. Implementing the therapy includes increasing or decreasing sympathetic activity in sympathetic nerves branching from a first region of the spinal cord using a first electrode in the thoracic duct, and further includes increasing or decreasing parasympathetic activity in parasympathetic nerves adjacent to the desired thoracic lymphatic vessel or sympathetic activity in sympathetic nerves branching from a second region of the spinal cord using a second electrode in the desired thoracic lymphatic vessel.
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Citations
28 Claims
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1. A system for modulating autonomic neural activity in a body having a spinal cord, a subclavian vein and thoracic lymphatic vessels that include a thoracic duct and a right lymphatic duct, the system comprising:
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at least one stimulation lead including at least a first electrode region and a second electrode region, the at least one stimulation lead being adapted to be fed through the subclavian vein into a desired thoracic lymphatic vessel to operationally position the first electrode region in the thoracic lymphatic vessel to stimulate sympathetic nerves branching from a first region of the spinal cord and to operationally position the second electrode region in the desired thoracic lymphatic vessel to stimulate sympathetic nerves branching from a second region of the spinal cord or stimulate parasympathetic nerves anatomically adjacent to the desired thoracic lymphatic vessel; and a programmable neural stimulator programmed to deliver neural stimulation pulses to the first electrode region to modulate sympathetic activity in the sympathetic nerves branching from the first region of the spinal cord and to deliver neural stimulation pulses to the second electrode region to modulate sympathetic activity in the sympathetic nerves branching from the second region of the spinal cord or to modulate parasympathetic activity in the parasympathetic nerves anatomically adjacent to the desired thoracic lymphatic vessel. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18)
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19. A method for modulating autonomic neural activity in a body having a spinal cord, a subclavian vein and thoracic lymphatic vessels that include a thoracic duct and a right lymphatic duct, the method comprising:
implementing at least one programmed therapy using an implanted medical device to modulate autonomic neural activity, wherein implementing at least one programmed therapy includes; increasing or decreasing sympathetic activity in sympathetic nerves branching from a first region of the spinal cord using a first electrode in a desired thoracic lymphatic vessel; and increasing or decreasing parasympathetic activity in parasympathetic nerves adjacent to the desired thoracic lymphatic vessel or sympathetic activity in sympathetic nerves branching from a second region of the spinal cord using a second electrode in the desired thoracic lymphatic vessel. - View Dependent Claims (20, 21, 22, 23, 24, 25, 26)
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27. A method for implanting a system for modulating both parasympathetic and sympathetic activity in a body having a spinal cord, a subclavian vein and thoracic lymphatic vessels that include a thoracic duct and a right lymphatic duct, the method comprising:
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feeding at least one stimulation lead through the subclavian vein into the thoracic lymphatic vessels to operationally position a first electrode region in a desired thoracic lymphatic vessel to stimulate sympathetic nerves branching from a first region of the spinal cord and to operationally position a second electrode region in the thoracic duct to stimulate parasympathetic nerves adjacent to the desired thoracic lymphatic vessel; implanting a programmable neural stimulator; operationally attaching the programmable neural stimulator to the at least one stimulation lead to stimulate the sympathetic nerves and parasympathetic nerves; and implementing a test routine to verify capture of the sympathetic nerves and parasympathetic nerves. - View Dependent Claims (28)
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Specification