USE OF OLIGOSACCHARIDES CONTAINING N-ACETYLLACTOSAMINE FOR MATURATION OF IMMUNE RESPONSES IN NEONATES

• US 20100233198A1
• Filed: 11/07/2008
• Published: 09/16/2010
• Est. Priority Date: 11/08/2007
• Status: Abandoned Application

• Current Assignee: Nestec SA (Nestle SA)
• Original Assignee: Nestec SA (Nestle SA)
• Inventors: Sprenger, Norbert, Fichot, Marie-Claire
• Application Number:
  US12/741,997
• Publication Number:
  US 20100233198A1
• Time in Patent Office: Days
• US Class Current: 424/184.100
• CPC Class Codes: A23L 29/30 containing carbohydrate syrups; containing sugars; containing sugar alcohols, e.g. xylitol; containing starch hydrolysates, e.g. dextrin products from apiculture A23L21/20; artificial sweetening agents A23L27/30
• CPC Class Codes: A23L 33/40 Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
• CPC Class Codes: A23V 2002/00 Food compositions, function of food ingredients or processes for food or foodstuffs
• CPC Class Codes: A23V 2200/3202 Prebiotics, ingredients fermented in the gastrointestinal tract by beneficial microflora
• CPC Class Codes: A23V 2200/324 having an effect on the immune system
• CPC Class Codes: A23V 2250/28 Oligosaccharides
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/7028 Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
• CPC Class Codes: A61K 35/741 Probiotics probiotic yeast, e.g. saccharomyces A61K36/06
• CPC Class Codes: A61P 37/02 Immunomodulators
• CPC Class Codes: A61P 37/04 Immunostimulants
• CPC Class Codes: A61P 37/08 Antiallergic agents antiasthmatic agents A61P11/06; ophthalmic antiallergics A61P27/14

Abstract

This invention relates to the use of an oligosaccharide selected from the group consisting of lacto-N-tetraose, lacto-N-neotetraose, lacto-N-hexaose, lacto-N-neohexaose, para-lacto-N-hexaose, para-lacto-N-neohexaose, lacto-N-octaose, lacto-N-neooctaose, iso-lacto-N-octaose, para-lacto-N-octaose and lacto-N-decaose in the manufacture of a medicament for infants or a therapeutic nutritional composition for infants for modulating immune responses in a neonatal infant. The invention extends to the use of such an oligosaccharide for modulating the immune system of a neonatal infant to promote the development in the first few weeks of the life of the infant of a beneficial intestinal microbiota comparable with that found in breast fed infants and for reducing the risk of subsequent development of allergy in the infant.

Claims

1. A method for assisting in the maturation of immune responses in a neonatal infant comprising the step of administering a composition to the neonatal infant comprising an oligosaccharide selected from the group consisting of lacto-N-tetraose, lacto-N-neotetraose, lacto-N-hexaose, lacto-N-neohexaose, para-lacto-N-hexaose, para-lacto-N-neohexaose, lacto-N-octaose, lacto-N-neooctaose, iso-lacto-N-octaose, para-lacto-N-octaose and lacto-N-decaose.

4. The method of claim 1, wherein the oligosaccharide is lacto-N-tetraose or lacto-N-neotetraose.

5. The method of claim 1, wherein the composition is an infant formula.

6. The use of claim 5, wherein the infant formula contains from 0.1 to 3 g of an oligosaccharide selected from the group consisting of lacto-N-tetraose, lacto-N-neotetraose, lacto-N-hexaose, lacto-N-neohexaose, para-lacto-N-hexaose, para-lacto-N-neohexaose, lacto-N-octaose, lacto-N-neooctaose, iso-lacto-N-octaose, para-lacto-N-octaose and lacto-N-decaose per 100 g formula.

7. The method of claim 5, where the infant formula comprises a probiotic bacterial strain in an amount of from 10e3 to 10e12 cfu/g formula on a dry weight basis.

8. The method of claim 5, wherein the infant formula comprises at least one prebiotic in an amount of from 0.3 to 10% by weight of the formula.

9. The method of claim 1, wherein the composition is a supplement which comprises from 0.1 to 3 g of an oligosaccharide selected from the group consisting of lacto-N-tetraose, lacto-N-neotetraose, lacto-N-hexaose, lacto-N-neohexaose, para-lacto-N-hexaose, para-lacto-N-neohexaose, lacto-N-octaose, lacto-N-neooctaose, iso-lacto-N-octaose, para-lacto-N-octaose and lacto-N-decaose per daily dose.

10. The method of claim 1, wherein the composition is administered to the infant immediately after delivery and thereafter for at least 2 months.

11. The method of claim 1, wherein the composition is selected from the group consisting of medicament and therapeutic nutritional composition.

2. A method for modulating the immune system of a neonatal infant to promote the development in the first few weeks of the life of the infant of a beneficial intestinal microbiota comparable with that found in breast fed infants comprising the step of administering a composition comprising an oligosaccharide selected from the group consisting of lacto-N-tetraose, lacto-N-neotetraose, lacto-N-hexaose, lacto-N-neohexaose, para-lacto-N-hexaose, para-lacto-N-neohexaose, lacto-N-octaose, lacto-N-neooctaose, iso-lacto-N-octaose, para-lacto-N-octaose and lacto-N-decaose.

12. The method of claim 2, wherein the oligosaccharide is lacto-N-tetraose or lacto-N-neotetraose.

13. The method of claim 2, wherein the composition is an infant formula.

14. The use of claim 13, wherein the infant formula contains from 0.1 to 3 g of an oligosaccharide selected from the group consisting of lacto-N-tetraose, lacto-N-neotetraose, lacto-N-hexaose, lacto-N-neohexaose, para-lacto-N-hexaose, para-lacto-N-neohexaose, lacto-N-octaose, lacto-N-neooctaose, iso-lacto-N-octaose, para-lacto-N-octaose and lacto-N-decaose per 100 g formula.

15. The method of claim 13, where the infant formula comprises a probiotic bacterial strain in an amount of from 10e3 to 10e12 cfu/g formula on a dry weight basis.

16. The method of claim 13, wherein the infant formula comprises at least one prebiotic in an amount of from 0.3 to 10% by weight of the formula.

17. The method of claim 2, wherein the composition is a supplement which comprises from 0.1 to 3 g of an oligosaccharide selected from the group consisting of lacto-N-tetraose, lacto-N-neotetraose, lacto-N-hexaose, lacto-N-neohexaose, para-lacto-N-hexaose, para-lacto-N-neohexaose, lacto-N-octaose, lacto-N-neooctaose, iso-lacto-N-octaose, para-lacto-N-octaose and lacto-N-decaose per daily dose.

18. The method of claim 2, wherein the composition is administered to the infant immediately after delivery and thereafter for at least 2 months.

19. The method of claim 2, wherein the composition is selected from the group consisting of medicament and therapeutic nutritional composition.

3. A method for reducing the risk of subsequent development of allergy in an infant comprising the step of administering to the infant a composition comprising an oligosaccharide selected from the group consisting of lacto-N-tetraose, lacto-N-neotetraose, lacto-N-hexaose, lacto-N-neohexaose, para-lacto-N-hexaose, para-lacto-N-neohexaose, lacto-N-octaose, lacto-N-neooctaose, iso-lacto-N-octaose, para-lacto-N-octaose and lacto-N-decaose.

20. The method of claim 3, wherein the oligosaccharide is lacto-N-tetraose or lacto-N-neotetraose.

21. The method of claim 3, wherein the composition is an infant formula.

22. The use of claim 21, wherein the infant formula contains from 0.1 to 3 g of an oligosaccharide selected from the group consisting of lacto-N-tetraose, lacto-N-neotetraose, lacto-N-hexaose, lacto-N-neohexaose, para-lacto-N-hexaose, para-lacto-N-neohexaose, lacto-N-octaose, lacto-N-neooctaose, iso-lacto-N-octaose, para-lacto-N-octaose and lacto-N-decaose per 100 g formula.

23. The method of claim 21, where the infant formula comprises a probiotic bacterial strain in an amount of from 10e3 to 10e12 cfu/g formula on a dry weight basis.

24. The method of claim 21, wherein the infant formula comprises at least one prebiotic in an amount of from 0.3 to 10% by weight of the formula.

25. The method of claim 3, wherein the composition is a supplement which comprises from 0.1 to 3 g of an oligosaccharide selected from the group consisting of lacto-N-tetraose, lacto-N-neotetraose, lacto-N-hexaose, lacto-N-neohexaose, para-lacto-N-hexaose, para-lacto-N-neohexaose, lacto-N-octaose, lacto-N-neooctaose, iso-lacto-N-octaose, para-lacto-N-octaose and lacto-N-decaose per daily dose.

26. The method of claim 3, wherein the composition is administered to the infant immediately after delivery and thereafter for at least 2 months.

27. The method of claim 3, wherein the composition is selected from the group consisting of medicament and therapeutic nutritional composition.