DRUG COATED EXPANDABLE DEVICES
First Claim
Patent Images
1. A medical device comprising:
- an expandable member having a first diameter for insertion into a vessel and a second diameter for making contact with the vessel walls; and
a liquid formulation of a rapamycin affixed to at least a portion of the surface of the expandable member, the liquid formulation of a rapamycin comprising about 50 mg/ml of a rapamycin, about 5 mg/ml of a first excipient selected from the group of polymers consisting of PEG 400, PEG 1000, PEG 1500, PEG 2000 and polyvinyl alcohol, about 5 mg/ml of a second excipient selected from the group of antioxidants consisting of BHT, BHA and vitamin E TPGS, ascorbyl palmitate, resveratrol, and acetone and water in a ratio of about 60/40 to about 75/25.
2 Assignments
0 Petitions
Accused Products
Abstract
Medical devices may be utilized for local and regional therapeutic agent delivery. These therapeutic agents or compounds may reduce a biological organism'"'"'s reaction to the introduction of the medical device to the organism. In addition, these therapeutic drugs, agents and/or compounds may be utilized to promote healing, including the prevention of thrombosis. The drugs, agents, and/or compounds may also be utilized to treat specific disorders, including restenosis, vulnerable plaque, and atherosclerosis in type 2 diabetic patients.
103 Citations
11 Claims
-
1. A medical device comprising:
-
an expandable member having a first diameter for insertion into a vessel and a second diameter for making contact with the vessel walls; and a liquid formulation of a rapamycin affixed to at least a portion of the surface of the expandable member, the liquid formulation of a rapamycin comprising about 50 mg/ml of a rapamycin, about 5 mg/ml of a first excipient selected from the group of polymers consisting of PEG 400, PEG 1000, PEG 1500, PEG 2000 and polyvinyl alcohol, about 5 mg/ml of a second excipient selected from the group of antioxidants consisting of BHT, BHA and vitamin E TPGS, ascorbyl palmitate, resveratrol, and acetone and water in a ratio of about 60/40 to about 75/25. - View Dependent Claims (2, 3, 4)
-
-
5. A method for coating a device comprising:
-
making a liquid formulation of a rapamycin comprising about 50 mg/ml of a rapamycin, about 5 mg/ml of a first excipient selected from the group of polymers consisting of PEG 400, PEG 100, PEG 1500, PEG 2000 and polyvinyl alcohol, about 5 mg/ml of a second excipient selected from the group of antioxidants consisting of BHT, BHA and vitamin E TPGS, ascorbyl palmitate, resveratrol, and acetone and water in a ratio of about 60/40 to about 75/25; coating an expandable device with the liquid formulation for less than 10 seconds; drying the coated expandable device for about 10 minutes; recoating the expandable device with the liquid formulation for less than 5 seconds; and drying the recoated expandable device for about 10 minutes. - View Dependent Claims (6)
-
- 7. A liquid formulation of a rapamycin comprising about 50 mg/ml of a rapamycin, about 50 mg/ml of a first excipient selected from the group of polymers consisting of PEG 400, PEG 1000, PEG 1500, PEG 2000 and polyvinyl alcohol, about 5 mg/ml of a second excipient selected from the group of antioxidants consisting of BHT, BHA and vitamin E TPGS, ascorbyl palmitate, resveratrol, and acetone and water in a ratio of about 60/40 to about 75/25.
-
9. A method for the treatment of vascular disease comprising:
-
positioning an expandable member having a first unexpanded diameter proximate a treatment site of a diseased vessel; and expanding the expandable member to a second diameter such that it makes contact with the vessel walls at the treatment site, the expandable member having a coating comprising about 50 mg/ml of a rapamycin, about 5 mg/ml of a first excipient selected from the group of polymers consisting of PEG 400, PEG 100, PEG 1500, PEG 2000 and polyvinyl alcohol, about 5 mg/ml of a second excipient selected from the group of antioxidants consisting of BHT, BHA and vitamin E TPGS, ascorbyl palmitate, resveratrol, and acetone and water in a ratio of about 60/40 to about 75/25, wherein the expansion of the expandable member to its second diameter facilitates the uptake of the liquid formulation into the tissues comprising the vessel walls. - View Dependent Claims (10, 11)
-
Specification