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MULTIPURPOSE ANALYSIS USING SECOND HARMONIC GENERATING NANOPROBES

  • US 20100233820A1
  • Filed: 01/20/2010
  • Published: 09/16/2010
  • Est. Priority Date: 01/21/2009
  • Status: Active Grant
First Claim
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1. A second harmonic generating (SHG) nanoprobe system for nucleotide sequencing comprising:

  • a plurality of distinct SHG nanoprobes, each of said distinct SHG nanoprobes having no inversion symmetry such that each SHG nanoprobe generates a distinct harmonic emission when radiated by an external excitation source at least two wavelengths; and

    an external excitation source for radiating the plurality of SHG nanoprobes;

    wherein each of said distinct SHG nanoprobes is assigned and linked to a distinct nucleotide type and radiated by the external excitation source at least two frequencies such that a distinct emissive fingerprint is generated for each of said nucleotide types.

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