Soluble Hydrophobic Core Carrier Compositions for Delivery of Therapeutic Agents, Methods of Making and Using the Same
First Claim
1. A soluble hydrophobic-core carrier composition comprising:
- (i) a linear polymeric backbone;
(ii) a plurality of hydrophilic polymeric protective chains covalently linked and pendant to the polymeric backbone, wherein each protective side chain has a molecular weight between about 400 and about 20,000 Daltons; and
(iii) at least one hydrophobic moiety covalently linked and pendant to the polymeric backbone;
wherein the weight ratio of the hydrophilic polymeric protective side chains and the hydrophobic moieties is selected so that the composition is soluble in water.
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Abstract
The present invention relates to a soluble hydrophobic-core carrier composition comprising (i) a linear polymeric backbone; (ii) a plurality of hydrophilic polymeric protective chains covalently linked and pendant to the polymeric backbone and (iii) at least one hydrophobic moiety covalently linked and pendant to the polymeric backbone. In certain embodiments, the weight ratio of hydrophilic protective chains to hydrophobic moieties in the carrier is at least 15:1. In other embodiments, at least 90% of the residues of the polymeric backbone are coupled to a hydrophilic polymeric protective chain or a hydrophobic moiety. In other embodiments, the composition further comprises (iv) a hydrophobic load molecule dissociably linked to the hydrophobic moiety of the carrier.
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Citations
32 Claims
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1. A soluble hydrophobic-core carrier composition comprising:
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(i) a linear polymeric backbone; (ii) a plurality of hydrophilic polymeric protective chains covalently linked and pendant to the polymeric backbone, wherein each protective side chain has a molecular weight between about 400 and about 20,000 Daltons; and (iii) at least one hydrophobic moiety covalently linked and pendant to the polymeric backbone; wherein the weight ratio of the hydrophilic polymeric protective side chains and the hydrophobic moieties is selected so that the composition is soluble in water. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 14, 15, 16, 20, 21, 22, 23, 24, 25)
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13. (canceled)
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17. (canceled)
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18. (canceled)
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19. (canceled)
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26. (canceled)
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27. (canceled)
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28. (canceled)
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29. (canceled)
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30. A method of administering a therapeutic molecule to a subject comprising:
administering to the subject a composition comprising; (i) a linear polymeric backbone; (ii) a plurality of hydrophilic polymeric protective chains covalently linked and pendant to the polymeric backbone, wherein each protective side chain has a molecular weight between about 400 and about 20,000 Daltons; (iii) at least one hydrophobic moiety covalently linked and pendant to the polymeric backbone; (iv) a therapeutic molecule dissociably linked to the hydrophobic moiety of the backbone; wherein the weight ratio of the hydrophilic polymeric protective side chains and the hydrophobic moieties is selected so that the composition is soluble in water.
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31. (canceled)
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32. (canceled)
Specification