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Novel Estrogenic Compounds

  • US 20100234330A1
  • Filed: 05/27/2010
  • Published: 09/16/2010
  • Est. Priority Date: 07/23/2003
  • Status: Active Grant
First Claim
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1. A topical pharmaceutical formulation comprising:

  • (a) a compound represented by the following Formula;

    or pharmaceutically acceptable salts thereof wherein;

    R and R1 are each independently hydrogen, sulfate or glucuronide and said compound has the following physicochemical properties;

    (i) a peak located at about 1.2 ppm in a 1H-NMR spectrum; and

    (ii) a peak located at about 45 ppm in a 13C-NMR spectrum. said compound being present in chemically pure form; and

    (b) a pharmaceutically active ingredient selected from the group consisting of estrogenic compounds, androgenic compounds, progestin compounds, vasodilation agents, calcium salts, and vitamin D, and mixtures and combinations thereof.

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