HINDERED ESTER-BASED BIODEGRADABLE LINKERS FOR OLIGONUCLEOTIDE DELIVERY
First Claim
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1. A compound comprising a structure according to Formula (I)
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Abstract
The invention provides hindered ester-based biodegradable linkers for the delivery of oligonucleotides in vivo, as well as method of making and using the same.
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30 Claims
- 1. A compound comprising a structure according to Formula (I)
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28. A method of preparing a hindered acyl or ester moiety-containing polymeric conjugate comprising:
reacting a compound of Formula (VI);
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29. A method of treating a mammal, comprising administering an effective amount of a compound of Formula (Ia) to a patient in need thereof.
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30. A method of administering polynucleotides to mammalian cells, comprising delivering an effective amount of a compound of Formula (Ia) to a cell requiring such treatment.
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