BIOMIMETIC VASCULAR NETWORK AND DEVICES USING THE SAME
2 Assignments
0 Petitions
Accused Products
Abstract
The invention provides method of fabricating a scaffold comprising a fluidic network, including the steps of: (a) generating an initial vascular layer for enclosing the chamber and providing fluid to the cells, the initial vascular layer having a network of channels for fluid; (b) translating the initial vascular layer into a model for fluid dynamics analysis; (c) analyzing the initial vascular layer based on desired parameters selected from the group consisting of a characteristic of a specific fluid, an input pressure, an output pressure, an overall flow rate and combinations thereof to determine sheer stress and velocity within the network of channels; (d) measuring the sheer stress and the velocity and comparing the obtained values to predetermined values; (e) determining if either of the shear stress or the velocity are greater than or less than the predetermined values, and (f) optionally modifying the initial vascular layer and repeating steps (b)-(e). The invention also provides compositions comprising a vascular layer for use in tissue lamina as well as a medical devices having a vascular layer and kits.
-
Citations
106 Claims
-
1-70. -70. (canceled)
-
71. An artificial vascular layer comprising:
-
a substrate defining a network of channels having at least one input channel and at least one output channel and at least two intermediate channels at least partially connecting the at least one input channel and the at least one output channel, each channel having a height, a length, and a width, and a diameter, wherein the intermediate channels are formed in accordance with Murray'"'"'s law by varying said height and width of the intermediate channels with respect to adjacent channels, and the length of at least one of the intermediate channels is formed based on the diameter of said channel, whereby said channel has a biomimetic length. - View Dependent Claims (72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84)
-
-
85. A device comprising:
-
a first substrate defining a vasculature layer having at least one input channel, at least one output channel, and at least two intermediate channels at least partially connecting the at least one input channel and the at least one output channel, each channel having a height, a length, and a width, and a diameter; a second substrate defining a cellular layer coupled to first substrate, the cellular layer defining a chamber for holding parenchymal cells and configured to receive oxygen and nutrients from a fluid in the vascular layer; and a semi-permeable membrane separating the vasculature layer and the cellular layer; wherein; the intermediate channels are formed in accordance with Murray'"'"'s law by varying said height and width of the intermediate channels with respect to adjacent channels, and the length of at least one of the intermediate channels is formed based on the diameter of said channel, whereby said channel has a biomimetic length. - View Dependent Claims (86, 87, 88, 89, 90, 91)
-
-
92. A method of manufacturing artificial vasculature, comprising:
-
providing a substrate; forming, in the substrate, a network of channels, including at least one input channel, at least one output channel, and at least two intermediate channels at least partially connecting the at least one input channel and the at least one output channel, each channel having a height, a length, and a width, and a diameter, wherein the intermediate channels are formed in accordance with Murray'"'"'s law by varying said height and width of the intermediate channels with respect to adjacent channels, and the length of at least one of the intermediate channels is formed based on the diameter of said channel, whereby said channel has a biomimetic length. - View Dependent Claims (93, 94, 95, 96, 97, 98, 99, 100, 101, 102)
-
-
103. A method of at least partially replacing the function of an organ in a patient, comprising:
-
providing an artificial organ device comprising a first substrate coupled to a second substrate and separated by a semi-permeable membrane;
whereinthe first substrate defines a vasculature layer having at least one input channel, at least one output channel, and at least two intermediate channels at least partially connecting the at least one input channel and the at least one output channel, each channel having a height, a length, and a width, and a diameter, the intermediate channels are formed in accordance with Murray'"'"'s law by varying said height and width of the intermediate channels with respect to adjacent channels, and the length of at least one of the intermediate channels is formed based on the diameter of said channel, whereby said channel has a biomimetic length, and the a second substrate defines a cellular layer coupled to the first substrate, the cellular layer defining a chamber for holding parenchymal cells and configured to receive oxygen and nutrients from a fluid in the vascular layer; and coupling the artificial organ device to at least one arterial vessel and one venous vessel of the patient. - View Dependent Claims (104, 105, 106)
-
Specification