METHOD AND APPARATUS FOR DETECTION OF MULTIPLE ANALYTES
First Claim
1. A body fluid analysis apparatus comprising:
- a fluid handling network including a patient end configured to maintain fluid communication with a bodily fluid in a patient;
a valve system in operative engagement with the fluid handling network, the valve system having an infusion mode in which the valve system is operable to deliver infusion fluid to the patient through the patient end, and a sample draw mode in which the valve system is operable to draw a sample of the bodily fluid from the patient through the patient end;
an infrared spectroscopic analyzer positioned to analyze at least a portion of the sample;
a processor in communication with or incorporated into the spectroscopic analyzer; and
stored program instructions executable by the processor to obtain measurements of two or more properties of the sample, wherein the program instructions are configured to cause the fluid analyzer to;
obtain a spectral characterization of the at least a portion of the sample, the spectral characterization incorporating one or more mid-infrared wavelengths;
analyze the spectral characterization to obtain a measurement of the level of a first analyte in at least a portion of the sample; and
analyze the same spectral characterization to obtain a measurement of the level of a second analyte in at least a portion of the sample when the first analyte and the second analyte have overlapping spectral features, such that the results of the spectral characterization are sensitive both the first analyte and the second analyte.
0 Assignments
0 Petitions
Accused Products
Abstract
In some embodiments, an apparatus analyzes the composition of bodily fluid. The apparatus comprises a fluid handling network including a patient end configured to maintain fluid communication with a bodily fluid in a patient and at least one pump intermittently operable to draw a sample of bodily fluid from the patient. The apparatus further comprises a fluid analyzer positioned to analyze at least a portion of the sample and measure the presence of two or more analytes. Also disclosed is a method for analyzing the composition of a bodily fluid in a patient. The method comprises drawing a sample of the bodily fluid of the patient through a fluid handling network configured to maintain fluid communication with a bodily fluid in a patient. The method further comprises analyzing the at least a portion of the sample in a fluid analyzer to estimate the concentration of two or more analytes in the sample.
123 Citations
18 Claims
-
1. A body fluid analysis apparatus comprising:
-
a fluid handling network including a patient end configured to maintain fluid communication with a bodily fluid in a patient; a valve system in operative engagement with the fluid handling network, the valve system having an infusion mode in which the valve system is operable to deliver infusion fluid to the patient through the patient end, and a sample draw mode in which the valve system is operable to draw a sample of the bodily fluid from the patient through the patient end; an infrared spectroscopic analyzer positioned to analyze at least a portion of the sample; a processor in communication with or incorporated into the spectroscopic analyzer; and stored program instructions executable by the processor to obtain measurements of two or more properties of the sample, wherein the program instructions are configured to cause the fluid analyzer to; obtain a spectral characterization of the at least a portion of the sample, the spectral characterization incorporating one or more mid-infrared wavelengths; analyze the spectral characterization to obtain a measurement of the level of a first analyte in at least a portion of the sample; and analyze the same spectral characterization to obtain a measurement of the level of a second analyte in at least a portion of the sample when the first analyte and the second analyte have overlapping spectral features, such that the results of the spectral characterization are sensitive both the first analyte and the second analyte. - View Dependent Claims (2, 3, 4, 5, 6)
-
-
7. A method of analyzing body fluid, the method comprising:
-
drawing a sample of the bodily fluid of the patient through a fluid handling network configured to maintain fluid communication with a bodily fluid in a patient; directing at least a portion of the sample to an infrared spectroscopic analyzer connected to the fluid handling network; obtaining a spectral characterization from the at least a portion of the sample in the infrared spectroscopic analyzer, the spectral characterization including one or more mid-infrared wavelengths; and analyzing the at least a portion of the sample in the infrared spectroscopic analyzer to obtain two or more analyte levels by; analyzing the spectral characterization to obtain an estimate of a level of a first analyte in the at least a portion of the sample; and analyzing the same spectral characterization to obtain an estimate of a level of a second analyte in the at least a portion of the sample. - View Dependent Claims (8, 9, 10, 11, 12, 18)
-
-
13. An apparatus for analyzing the composition of bodily fluid, the apparatus comprising:
-
a fluid handling network including a patient end configured to maintain fluid communication with a bodily fluid in a patient; a valve system in operative engagement with the fluid handling network, the valve system having an infusion mode in which the valve system is operable to deliver infusion fluid to the patient through the patient end, and a sample draw mode in which the valve system is operable to draw a sample of the bodily fluid from the patient through the patient end; a infrared spectroscopic analyzer positioned to analyze at least a portion of the sample; a processor in communication with or incorporated into the infrared spectroscopic analyzer; and stored program instructions executable by the processor to obtain measurements of the levels of two or more analytes in the at least a portion of the sample, wherein the program instructions are configured to cause the infrared spectroscopic analyzer to; obtain a spectral characterization from the at least a portion of the sample in the infrared spectroscopic analyzer, the spectral characterization including one or more mid-infrared wavelengths; analyze the spectral characterization to obtain an estimate of a level of a first analyte in the at least a portion of the sample; and analyze the same spectral characterization to obtain an estimate of a level of a second analyte in the at least a portion of the sample. - View Dependent Claims (14, 15, 16, 17)
-
Specification