Non-Invasive Polarimetric Apparatus and Method for Analyte Sensing in Birefringent Media
First Claim
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1. A noninvasive polarimetric apparatus used to measure levels of a substance in a sample, in which the sample may exhibit dynamically changing birefringence comprising:
- a polarization system configured to generate multiple states of polarized light which interact with a given sample; and
,an analyzer system configured to receive the resulting signal and generate a secondary signal which can be further processed to measure levels of a substance in the sample.
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Abstract
A noninvasive polarimetric apparatus used to measure levels of a substance in a sample in the presence of dynamically changing sample birefringence is provided. A polarization system generates multiple states of polarized light which interact with the sample. An analyzer system receives a signal from the sample and generates a secondary signal. This signal is detected and then processed to measure levels of a substance in a sample that may be have time varying birefringent components.
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Citations
42 Claims
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1. A noninvasive polarimetric apparatus used to measure levels of a substance in a sample, in which the sample may exhibit dynamically changing birefringence comprising:
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a polarization system configured to generate multiple states of polarized light which interact with a given sample; and
,an analyzer system configured to receive the resulting signal and generate a secondary signal which can be further processed to measure levels of a substance in the sample. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 10, 11, 12, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40)
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9. A polarimeter according to, wherein the polarized light oscillates between left and right circularly polarized light, with elliptically polarized light between the left and right circularly polarized light.
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13. A noninvasive polarimetric apparatus used to measure levels of a substance in a sample, which may be birefringent in nature, dynamically changing sample birefringence comprising:
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at least one light source, at least one vertical polarizer, a polarization system configured to generate multiple states of polarized light which interact with a given sample, and an analyzer system configured to receive a signal obtained by the sample and generate a secondary signal which may be processed to measure levels of a substance in a sample, and at least one horizontal polarizer.
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41. A noninvasive method for measuring levels of a substance in a sample in the presence of dynamically changing birefringence comprising:
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generating states of polarized light wherein phase delays are introduced in the polarized light, at least partially interacting with the sample with the generated polarized light signal(s), and receiving a signal obtained by the sample and generating a secondary signal through an analyzer system.
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42. A non-invasive in vivo method for sensing a concentration of an optically active substance in an animal'"'"'s eye wherein the method comprises the steps of:
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generating states of polarized light wherein phase delays are introduced in the polarized light, at least partially interacting with the sample with the generated polarized light, receiving a signal obtained by the sample and generating a secondary signal through an analyzer system.
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Specification