DEVICE AND METHOD FOR SAFE LOCATION AND MARKING OF A BIOPSY CAVITY

• US 20100234726A1
• Filed: 05/11/2010
• Published: 09/16/2010
• Est. Priority Date: 12/24/1998
• Status: Active Grant

• Current Assignee: Devicor Medical Products Incorporated (Danaher Corporation)
• Original Assignee: Devicor Medical Products Incorporated (Danaher Corporation)
• Inventors: Lebovic, Gail S., Bush, Mary Elizabeth, Wilson, Peter M., Morrissey, Anne B., Sutton, Douglas S., Conston, Stanley R., Sirimanne, D. Laksen, Fawzi, Natalie V.
• Granted Patent: US 9,492,570 B2
• Time in Patent Office: Days
• US Class Current: 600/426
• CPC Class Codes: A61B 2017/00539 hydraulically
• CPC Class Codes: A61B 2090/3925 ultrasonic
• CPC Class Codes: A61B 2090/3966 Radiopaque markers visible in an X-ray image
• CPC Class Codes: A61B 2090/3987 Applicators for implanting markers
• CPC Class Codes: A61B 2090/3995 Multi-modality markers
• CPC Class Codes: A61B 90/39 Markers, e.g. radio-opaque or breast lesions markers
• CPC Class Codes: A61K 49/006 Biological staining of tissues in vivo, e.g. methylene blue or toluidine blue O administered in the buccal area to detect epithelial cancer cells, dyes used for delineating tissues during surgery

Abstract

Cavity and sentinel lymph node marking 412 devices, marker delivery devices, and methods are disclosed. More particularly, upon insertion into a body, the cavity marking device and method enable one to determine the center, orientation, and periphery of the cavity by radiographic, mammography, echogenic, or other noninvasive imaging techniques. A composition and method are disclosed for locating the sentinel lymph node in a mammalian body to determine if cancerous cells have spread thereto. The composition is preferably a fluid composition consisting of a carrier fluid and some type of contrast agent; alternatively, the contrast agent may itself be a fluid and therefore not need a separate carrier fluid. This composition is capable of (1) deposition in or around a lesion and migration to and accumulation in the associated sentinel node, and (2) remote detection via any number of noninvasive techniques. Also disclosed is a method for remotely detecting the location of a sentinel node by (1) depositing a remotely detectable fluid in or around a lesion for migration to and accumulation in the associated sentinel node and (2) remotely detecting the location of that node with a minimum of trauma and toxicity to the patient. The composition and method may serve to mark a biopsy cavity, as well as mark the sentinel lymph node. The marking methods also may combine any of the features as described with the marking device and delivery device.

Claims

1-236. -236. (canceled)

237. A breast biopsy marker comprising:

a first non-bioabsorbable marker detectable by ultrasound; and

a second non-bioabsorbable metallic marker detectable by imaging means other than ultrasound wrapped about a portion of the first non-bioabsorbable marker.

238. The breast biopsy marker in accordance with claim 237 wherein the second marker is in the form of a coil.

239. A breast biopsy marker comprising:

a first polymer marker detectable by ultrasound; and

a second non-bioabsorbable metallic marker detectable by imaging means other than ultrasound wrapped about a portion of the first non-bioabsorbable marker.

240. The breast biopsy marker in accordance with claim 239 wherein the second marker is in the form of a coil