CASSETTE FOR SAMPLE PREPARATION
First Claim
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1. An apparatus, comprising:
- a first housing defining a first chamber, a second chamber and an opening in fluid communication with the first chamber, the first chamber configured to contain at least a sample and a plurality of magnetic particles;
a valve at least partially disposed within the first housing, the valve configured to transfer the plurality of magnetic particles between the first chamber and the second chamber while maintaining fluidic isolation between the first chamber and the second chamber;
a second housing defining a reagent chamber configured to contain a reagent; and
a plunger at least partially disposed within the reagent chamber, a portion of the second housing configured to be disposed within the first chamber of the first housing via the opening such that the reagent can be transferred from the reagent chamber to the first chamber of the first housing when the plunger is moved.
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Accused Products
Abstract
A cassette for preparing a sample is disclosed herein. The cassette includes a housing, which encloses the structures and the processes used to prepare the sample.
93 Citations
22 Claims
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1. An apparatus, comprising:
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a first housing defining a first chamber, a second chamber and an opening in fluid communication with the first chamber, the first chamber configured to contain at least a sample and a plurality of magnetic particles; a valve at least partially disposed within the first housing, the valve configured to transfer the plurality of magnetic particles between the first chamber and the second chamber while maintaining fluidic isolation between the first chamber and the second chamber; a second housing defining a reagent chamber configured to contain a reagent; and a plunger at least partially disposed within the reagent chamber, a portion of the second housing configured to be disposed within the first chamber of the first housing via the opening such that the reagent can be transferred from the reagent chamber to the first chamber of the first housing when the plunger is moved. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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9. An apparatus, comprising:
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a first housing defining a first chamber and a second chamber, the first chamber configured to contain at least a sample and a plurality of magnetic particles; a valve at least partially disposed within the first housing, the valve configured to transfer the plurality of magnetic particles between the first chamber and the second chamber while maintaining fluidic isolation between the first chamber and the second chamber; a second housing defining a reagent chamber configured to contain a reagent, the second housing configured to be coupled to the first housing such that the reagent chamber can be placed in fluid communication with the first chamber of the first housing; and a plunger at least partially disposed within the reagent chamber, the plunger configured to transfer the reagent from the reagent chamber to the first chamber of the first housing when the plunger is moved. - View Dependent Claims (11, 12, 13, 14, 15, 16, 17)
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10. The apparatus of 9, further comprising:
a pump coupled to the second housing, the pump fluidically coupled to an elongate tip disposed at least partially within the first chamber of the first housing, the pump configured to mix the reagent with the sample disposed within first chamber of the first housing.
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18. An apparatus, comprising:
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a first housing defining a first chamber and a second chamber, the first chamber configured to contain at least a sample and a plurality of magnetic particles; a valve at least partially disposed within the first housing, the valve configured to transfer the plurality of magnetic particles between the first chamber and the second chamber while maintaining fluidic isolation between the first chamber and the second chamber; and a second housing defining a reagent chamber configured to contain a reagent, the second housing configured to be coupled to the first housing such that the reagent chamber can be placed in fluid communication with the first chamber of the first housing; and a pump coupled to the second housing, the pump fluidically coupled to an elongate tip disposed at least partially within the first chamber of the first housing, the pump configured to convey the sample and the reagent between the first chamber of the first housing and an interior volume of the second housing. - View Dependent Claims (19, 20, 21, 22)
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Specification