Delivery system for delivering bioactive materials

• US 20100239629A1
• Filed: 07/31/2006
• Published: 09/23/2010
• Est. Priority Date: 07/31/2006
• Status: Abandoned Application

• Current Assignee: ISP Investments, Inc. (Ashland Global Holdings, Inc.)
• Original Assignee: ISP Investments, Inc. (Ashland Global Holdings, Inc.)
• Inventors: Winkowski, Karen, Patel, Jayanti, Narayanan, Kolazi S., Jon, Domingo
• Application Number:
  US11/496,599
• Publication Number:
  US 20100239629A1
• Time in Patent Office: Days
• US Class Current: 424/408
• CPC Class Codes: A01N 25/04 Dispersions, emulsions, suspoemulsions, suspension concentrates or gels foams A01N25/16
• CPC Class Codes: A01N 25/30 characterised by the surfactants
• CPC Class Codes: A01N 31/08 Oxygen or sulfur directly attached to an aromatic ring system
• CPC Class Codes: A01N 31/16 with two or more oxygen or sulfur atoms directly attached to the same aromatic ring system
• CPC Class Codes: A01N 37/38 having at least one oxygen or sulfur atom attached to an aromatic ring system
• CPC Class Codes: A01N 47/12 containing a —O—CO—N< group, or a thio analogue thereof, neither directly attached to a ring nor the nitrogen atom being a member of a heterocyclic ring

Abstract

A delivery system for delivering bioactive materials as an aqueous nanoparticle dispersion of a water soluble matrix of polyvinylpyrrolidone (PVP) polymer and copolymers thereof, and an anionic surfactant.

Claims

1. A delivery system for delivering bioactive materials comprising an aqueous nanoparticle dispersion of bioactive material and a water soluble matrix of (a) polyvinylpyrrolidone polymer, or copolymers thereof, and (b) an anionic surfactant, wherein (a) and (b) form a complex which can solubilize the bioactive material in water below the critical micellular concentration of the surfactant.

3. A delivery system according to claim 1 wherein the weight ratio of bioactive material to (a) is 1:

5 to 5;

0.5.

4. A delivery system according to claim 3 wherein said ratio is 1:

0.2 to 1;

2.

5. A delivery system according to claim 1 wherein the weight ratio of bioactive material to (b) is 1:

10 to 2;

1.

6. A delivery system according to claim 5 wherein said ratio is 1:

3 to 1;

5.

7. A delivery system according to claim 1 wherein the weight ratio of (a):

(b) is 10;

1 to 1;

10.

8. A delivery system according to claim 1 wherein said bioactive material is a disinfectant or mixture of disinfectants.

9. A delivery system according to claim 8 wherein said disinfectant is a phenolic compound.

10. A delivery system according to claim 8 wherein said disinfectant is selected from the group consisting of triclosan, chlorhexidine, iodopropargyl butyl carbamate (IPBC), orthophenyl phenol, parachlorometaxylenol (PCMX), parachloro ortho benzyl phenol, pine oil, mixed phenol disinfectants, mixed phenol and quats.

11. A delivery system according to claim 8 wherein said disinfectant is triclosan.

12. A composition comprising the delivery system of claim 1 and water of dilution.

13. A composition according to claim 12 wherein said bioactive material is present in an amount of 10 ppm to 10%.

14. A composition according to claim 12 wherein said bioactive material is present in an amount of 0.05 to 0.2%.

15. A composition according to claim 12 in which said bioactive mixture comprises triclosan.

17. A delivery system according to claim 1 comprising, by weight, 3% triclosan, 3% PVP K-30 and 10.5 sodium dodecyl sulfate.

18. A composition comprising the delivery system of claim 17 diluted with water at a ratio of 1/450 to a final concentration of 66 ppm triclosan, 66 ppm PVP K-30 and 230 ppm sodium dodecyl sulfate.

19. A composition according to claim 15 further including a bridging compound to bind proteinaceous material in the mouth for sustained release.

20. A composition according to claim 19 wherein said material is a tannin.

21. A tablet comprising the delivery system of claim 1.

2. (canceled)

16. (canceled)