APTAMER-TARGETED SIRNA TO PREVENT ATTENUATION OR SUPPRESSION OF A T CELL FUNCTION
First Claim
Patent Images
1. A composition for modulating immune cells comprising an aptamer-interference RNA (RNAi) fusion molecule wherein said molecule is targeted to cells and cellular molecules associated with regulation of an immune response and comprises at least one aptamer specific for at least one molecule.
1 Assignment
0 Petitions
Accused Products
Abstract
Compositions for countering immune attenuating/suppressive pathways comprise targeting agents or aptamer targeted RNAi-mediated gene silencing (siRNA/shRNA). These compositions have broad applicability in the treatment of many diseases.
-
Citations
45 Claims
- 1. A composition for modulating immune cells comprising an aptamer-interference RNA (RNAi) fusion molecule wherein said molecule is targeted to cells and cellular molecules associated with regulation of an immune response and comprises at least one aptamer specific for at least one molecule.
-
12. A method of modulating an immune response in patient comprising:
-
constructing an aptamer and/or targeting agent and interference RNA fusion molecule wherein the aptamer and/or targeting agent is specific for an immune effector cell and the interference RNA is specific for a molecule associated with attenuation or suppression of the immune effector cell; administering the fusion molecule in a therapeutically effective amount to the patient; and
,modulating the immune response. - View Dependent Claims (13, 14, 15, 16, 17, 18, 19, 20, 21)
-
- 22. An aptamer-interference RNA molecule comprising at least one aptamer specific for a marker of a target cell and at least one interference RNA molecule specific for a desired polynucleotide of the target cell.
- 33. A composition for modulating immune cells comprising a targeting agent-interference RNA (RNAi) fusion molecule wherein said molecule is targeted to cells and cellular molecules associated with regulation of an immune response, comprising at least one targeting agent which specifically binds to at least one molecule.
-
44. A method of treating tumors in vivo comprising:
-
administering to a patient in need thereof a therapeutically effective chimeric molecule which specifically binds to immune cells or cells in tumor vasculatures; and
,treating tumors in vivo. - View Dependent Claims (45)
-
Specification