Percutaneous Electrical Treatment Of Tissue

• US 20100241188A1
• Filed: 04/13/2009
• Published: 09/23/2010
• Est. Priority Date: 03/20/2009
• Status: Abandoned Application

• Current Assignee: electroCore, Inc., Electrocore, Llc
• Original Assignee: electroCore, Inc.
• Inventors: Errico, Joseph P., Mendez, Steven, Pastena, James R., Ross, Arthur, Simon, Bruce, Dickerson, Richard P., Hu, Hecheng
• Application Number:
  US12/422,483
• Publication Number:
  US 20100241188A1
• Time in Patent Office: Days
• US Class Current: 607/42
• CPC Class Codes: A61B 17/3415 for introducing tubes or catheters, e.g. gastrostomy tubes, drain catheters A61B17/3417 takes precedence; body piercing catheter guide needles A61M25/06
• CPC Class Codes: A61N 1/0526 Head electrodes A61N1/0551 takes precedence
• CPC Class Codes: A61N 1/0551 Spinal or peripheral nerve electrodes
• CPC Class Codes: A61N 1/3601 of respiratory organs

Abstract

Devices, systems and methods for applying electrical impulse(s) to one or more selected nerves in or around the carotid sheath are described. An electrode assembly is introduced through a percutaneous penetration in a patient to a target location adjacent to, or in close proximity with, the carotid sheath. Once in position, one or more electrical impulses are applied through the electrode assembly to one or more selected nerves to stimulate, block or otherwise modulate the nerve(s) and acutely treat the patient'"'"'s condition.

Claims

1. A method for acutely treating a condition or symptom of a patient comprising:

introducing an electrode through a percutaneous penetration in a patient to a target location adjacent to, or in close proximity with, the carotid sheath of the patient; and

applying an electrical impulse through the electrode to a selected nerve to modulate the selective nerve and acutely treat the condition or symptom of the patient.

2. The method of claim 1 wherein the introducing step is carried out by inserting a cannula through a skin surface in a neck of the patient and advancing the cannula to the target location proximal to the carotid sheath.

3. The method of claim 2 wherein the introducing step further comprises advancing the electrode through the cannula to a position parallel to the carotid sheath.

4. The method of claim 2 further comprising advancing an active and a return electrode through the cannula and applying an electrical voltage across the active and return electrodes.

5. The method of claim 1 further comprising stimulating one or more selected nerve fibers responsible for bronchial smooth muscle dilation to increase the activity of said nerve fibers.

6. The method of claim 1 wherein the electrical impulse is sufficient to acutely reduce a magnitude of bronchial constriction in a patient.

7. The method of claim 1 wherein the electrical impulse is of a frequency between about 15 Hz to 50 Hz.

8. The method of claim 1 wherein the electrical impulse is of an amplitude of between about 1 to 12 volts.

9. The method of claim 1 wherein the electrical impulse has a pulsed on-time of between about 50 to 500 microseconds.

10. The method of claim 1 wherein the selected nerve fibers are nonadrenergic noncholinergic nerve fibers.

11. The method of claim 1 further comprising increasing a blood pressure of the patient during the applying step.

12. The method of claim 1 further comprising at least partially improving peristalsis function during the applying step.

13. The method of claim 1 wherein the electrical impulse is sufficient to trigger an improvement in the patient'"'"'s condition or symptom in less than 3 hours.

14. The method of claim 1 wherein the electrical impulse is sufficient to trigger an improvement in the patient'"'"'s condition or symptom in less than 1 hour.

15. The method of claim 1 wherein the electrical impulse is sufficient to trigger an improvement in the patient'"'"'s condition or symptom in less than 15 minutes.

16. A device for acutely treating a condition of a patient comprising:

a source of electrical energy;

an introducer configured for creating percutaneous access to a target region adjacent to, or in close proximity with, a carotid sheath of a patient; and

an electrode assembly coupled to the source of electrical energy and comprising at least one electrode sized for advancing to the target region, wherein the source of electrical energy is configured to apply an electrical impulse through the electrode to a selected nerve at the target region sufficient to modulate the nerve and treat the condition of the patient.

17. The device of claim 16 wherein the introducer comprises:

an access device for creating percutaneous access through a skin surface of a neck of the patient to the target region; and

a cannula having an inner lumen.

18. The device of claim 16 wherein the electrode assembly comprises an active electrode, a return electrode and electrical leads coupling the active and return electrodes to the source of electrical energy.

19. The device of claim 16 wherein the access device comprises a needle.

20. The device of claim 16 wherein the electrical impulse is sufficient to stimulate one or more selected nerve fibers responsible for smooth muscle dilation to increase the activity of said nerve fibers.

21. The device of claim 16 wherein the electrical impulse is sufficient to acutely reduce a magnitude of bronchial constriction in a patient.

22. The device of claim 16 wherein the electrical impulse is of a frequency between about 15 Hz to 50 Hz.

23. The device of claim 16 wherein the electrical impulse is of an amplitude of between about 1 to 12 volts.

24. The device of claim 16 wherein the electrical impulse has a pulsed on-time of between about 50 to 500 microseconds.