Analyte Sensor
First Claim
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1. An electrochemical analyte sensor comprising:
- at least one electrode having an electroactive surface;
optionally an interference layer in contact with at least a portion of the electroactive surface; and
an enzyme layer comprising a hydrophilic polymer-enzyme composition, at least a portion of the enzyme layer covering the electroactive surface, the enzyme layer providing an electrochemically detectable species capable of providing a detectable output;
wherein sensor break-in is about 30 minutes or less immediately following deployment.
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Abstract
Electrochemical sensors for measuring an analyte in a subject are described. More particularly, devices for measurement of an analyte incorporating a sensor comprising a hydrophilic polymer-enzyme composition covering an electroactive surface providing rapid and accurate analyte levels upon deployment are disclosed.
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Citations
26 Claims
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1. An electrochemical analyte sensor comprising:
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at least one electrode having an electroactive surface; optionally an interference layer in contact with at least a portion of the electroactive surface; and an enzyme layer comprising a hydrophilic polymer-enzyme composition, at least a portion of the enzyme layer covering the electroactive surface, the enzyme layer providing an electrochemically detectable species capable of providing a detectable output; wherein sensor break-in is about 30 minutes or less immediately following deployment. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22)
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23. An electrochemical analyte sensor comprising:
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a flex circuit comprising at least one reference electrode and at least one conductive ink working electrode, at least one working electrode having an electroactive surface capable of providing a detectable electrical output upon interaction with an electrochemically detectable species; an optional cellulose acetate butyrate layer in contact with at least a portion of the electroactive surface; and an enzyme layer comprising poly-N-vinylpyrrolidone and glucose oxidase, the enzyme layer covering at least a portion of the electroactive surface of the working electrode; wherein the flex circuit is electrically configurable to a control unit capable of at least receiving the detectable electrical output; wherein sensor break-in is about 30 minutes or less immediately following deployment. - View Dependent Claims (24)
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25. A method of intravenously measuring an analyte in a subject, the method comprising:
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providing a catheter comprising a sensor, the sensor comprising; at least one electrode having an electroactive surface; optionally an interference layer in contact with at least a portion of the electroactive surface; and an enzyme layer comprising a hydrophilic polymer-enzyme composition, at least a portion of the enzyme layer covering the electroactive surface, the enzyme layer providing an electrochemically detectable species capable of providing a detectable output; introducing the catheter into the vascular system of a subject, wherein the sensor break-in is about 30 minutes or less immediately following deployment; and measuring an analyte.
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26. A method of intravenously measuring an analyte in a subject, the method comprising:
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providing a catheter comprising a sensor, the sensor comprising; a flex circuit comprising at least one reference electrode and at least one conductive ink working electrode, at least one working electrode having an electroactive surface capable of providing a detectable electrical output upon interaction with an electrochemically detectable species; an optional cellulose acetate butyrate layer in contact with at least a portion of the electroactive surface; and an enzyme layer comprising poly-N-vinylpyrrolidone and glucose oxidase, the enzyme layer covering at least a portion of the electroactive surface of the working electrode; wherein the flex circuit is electrically configurable to a control unit capable of at least receiving the detectable electrical output; introducing the catheter into the vascular system of a subject, wherein the sensor break-in is about 30 minutes or less immediately following deployment; and measuring an analyte.
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Specification