SYSTEMS AND METHODS FOR PHOTOACOUSTIC OPTHALMOSCOPY
First Claim
Patent Images
1. A multimodal imaging system comprising:
- a laser apparatus for generating a laser beam capable of irradiating a biological sample;
a dual-axis scanner operatively connected to the laser for scanning the laser beam across the biological sample;
an optical device for delivering the laser beam to the biological sample; and
an ultrasonic transducer for measuring laser induced ultrasonic waves.
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Abstract
Various embodiments of the present invention include systems and methods for multimodal functional imaging based upon photoacoustic and laser optical scanning microscopy. In particular, at least one embodiment of the present invention utilizes a contact lens in combination with an ultrasound transducer for purposes of acquiring photoacoustic microscopy data. Traditionally divergent imaging modalities such as confocal scanning laser ophthalmoscopy and photoacoustic microscopy are combined within a single laser system. Functional imaging of biological samples can be utilized for various medical and biological purposes.
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Citations
24 Claims
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1. A multimodal imaging system comprising:
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a laser apparatus for generating a laser beam capable of irradiating a biological sample; a dual-axis scanner operatively connected to the laser for scanning the laser beam across the biological sample; an optical device for delivering the laser beam to the biological sample; and an ultrasonic transducer for measuring laser induced ultrasonic waves. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. A method for noninvasive ophthalmic imaging, comprising:
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generating a laser beam capable of irradiating a biological sample, the laser beam being generated from a tunable laser system; scanning the laser beam with a dual-axis optical scanner; collimating and focusing the laser beam on the biological sample with an optical system; irradiating the biological sample based at least in part upon the focused laser beam; detecting photoacoustic waves in response to the irradiated biological sample; processing the photoacoustic signals; and generating an image of the biological sample based at least in part upon the processed photoacoustic signals. - View Dependent Claims (13, 14, 15, 16, 17, 18, 19, 20, 21)
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22. A method of ophthalmic imaging comprising:
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irradiating a ocular region of interest with a laser beam generated from a tunable laser; scanning the ocular region of interest using a dual-axis galvanometer capable of two-dimensional raster scanning; recording photoacoustic waves generated by the irradiated ophthalmic region; controlling the recording and scanning within a single time base; and generating an ophthalmic image based at least in part upon the recording and scanning.
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23. An ophthalmic imaging system comprising
a tunable laser for irradiating a biological sample with a laser beam; -
a two-dimensional galvanometer for raster scanning the laser beam across a field; an optical delivery apparatus for delivering the laser beam to the biological sample; a stationary ultrasound detector for detecting photoacoustic waves generated by an irradiated biological sample; and a processor for generating a functional retinal image based at least in part upon the detected photoacoustic waves.
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24. A laser scanning optical resolution photoacoustic microscope comprising:
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a tunable laser capable of irradiating a biological sample with a laser beam; a dual-axis galvanometer for raster scanning the laser beam; an optical delivery system for delivering the laser beam to the biological sample; and an ultrasound transducer integrated within a contact lens for detecting photoacoustic waves generated by the irradiated biological sample.
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Specification