Treatment of Muscular Dystrophy
First Claim
1. A cellular composition useful for treatment of a muscular dystrophy, said composition comprising an adherent population of cells derived from a group comprising of:
- the placental body, cord blood, Wharton'"'"'s Jelly, menstrual blood, endometrium, and amniotic fluid, administered at a concentration, frequency, and location sufficient to induce improvement in muscle function or inhibit deterioration of muscle function in a patient suffering from a muscular dystrophy.
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Abstract
The present invention provides mesenchymal stem cells and mesenchymal-like cells useful for treatment of muscular dystrophies including Duchenne Muscular Dystrophy (DMD), as well as, Becker, limb girdle, congenital, facioscapulohumeral, myotonic, oculopharyngeal, distal, and Emery-Dreifuss dystrophies. Also provided are protocols for administration of cells for treatment of the above dystrophies and adjuvant protocols. Futhermore, the invention teaches methods of manipulating mesenchymal and mesenchymal-like cells in vitro and in vivo for augmentation of therapeutic effects. Particularly, use of endometrial regenerative cells, alone or in combination with mesenchymal stem cells is provided for treatment of DMD and Becker muscular dystrophy.
24 Citations
30 Claims
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1. A cellular composition useful for treatment of a muscular dystrophy, said composition comprising an adherent population of cells derived from a group comprising of:
- the placental body, cord blood, Wharton'"'"'s Jelly, menstrual blood, endometrium, and amniotic fluid, administered at a concentration, frequency, and location sufficient to induce improvement in muscle function or inhibit deterioration of muscle function in a patient suffering from a muscular dystrophy.
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
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16. A cellular composition useful for treatment of muscular fibrosis associated with muscular dystrophy, said composition comprising an adherent population of cells derived from a group comprising of:
- the placental body, cord blood, Wharton'"'"'s Jelly, menstrual blood, endometrium, and amniotic fluid, administered at a concentration, frequency, and location sufficient to induce improvement in muscle function or inhibit deterioration of muscle function in a patient suffering from a muscular dystrophy.
- View Dependent Claims (17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30)
Specification