Three Dimensional Cell Protector/Pore Architecture Formation for Bone and Tissue Constructs

• US 20100247605A1
• Filed: 05/10/2010
• Published: 09/30/2010
• Est. Priority Date: 01/14/2005
• Status: Abandoned Application

• Current Assignee: American Dental Association Foundation (American Dental Association)
• Original Assignee: American Dental Association Foundation (American Dental Association)
• Inventors: Weir, Michael D., Xu, Huakun
• Application Number:
  US12/776,952
• Publication Number:
  US 20100247605A1
• Time in Patent Office: Days
• US Class Current: 424/423
• CPC Class Codes: A61K 38/1825 Fibroblast growth factor [FGF]
• CPC Class Codes: A61K 38/1841 Transforming growth factor [TGF]
• CPC Class Codes: A61K 38/1858 Platelet-derived growth factor [PDGF]
• CPC Class Codes: A61K 38/1875 Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
• CPC Class Codes: A61L 2400/06 Flowable or injectable implant compositions
• CPC Class Codes: A61L 2430/02 for reconstruction of bones; weight-bearing implants
• CPC Class Codes: A61L 27/20 Polysaccharides
• CPC Class Codes: A61L 27/38 containing added animal cells organs or tissue containing native cells A61L27/36
• CPC Class Codes: A61L 27/425 of phosphorus containing material, e.g. apatite
• CPC Class Codes: A61L 27/46 with phosphorus-containing inorganic fillers
• CPC Class Codes: A61L 27/58 Materials at least partially resorbable by the body
• CPC Class Codes: A61P 19/04 for non-specific disorders of the connective tissue
• CPC Class Codes: A61P 19/08 for bone diseases, e.g. rachitism, Paget's disease
• CPC Class Codes: C08L 5/04 Alginic acid; Derivatives thereof
• CPC Class Codes: C08L 5/08 Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
• CPC Class Codes: C08L 67/04 Polyesters derived from hydroxycarboxylic acids, e.g. lactones C08L67/06 takes precedence
• CPC Class Codes: C08L 89/06 derived from leather or skin , e.g. gelatin

Abstract

Living cellular material is encapsulated or placed in a protective material (cell protector) which is biocompatible, biodegradable and has a three-dimensional form. The three dimensional form is incorporated into a matrix that maybe implanted in vivo, ultimately degrade and thereby by replaced by living cell generated material.

Claims

1. A method of making an implant material for implantation of living cells comprising the steps of:

(a) forming a mixture of at least one species of living cells substantially contained in a biocompatible and biodegradable three dimensional cavity construction, said cavity construction at least in part contained in a carrier matrix which is biocompatible in vivo and with the cavity construction material which is biogradeable; and

(b) implanting the mixture in vivo.