INTRAOCULAR SUSTAINED RELEASE DRUG DELIVERY SYSTEMS AND METHODS FOR TREATING OCULAR CONDITIONS
First Claim
1. A method for treating elevated intraocular pressure, the method comprising the step of intracameral or anterior vitreal administration, to a patient with elevated intraocular pressure (IOP), of a sustained release implant comprising an anti-hypertensive agent and a biodegradable polymer, wherein the implant comprises from about 10 to about 50 weight percent the anti-hypertensive agent and from about 50 to about 90 weight percent the biodegradable polymer, and wherein the implant releases therapeutically effective amounts of the anti-hypertensive for a period of time between about 10 days and about 120 days.
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Accused Products
Abstract
Biocompatible, bioerodible sustained release implants and microspheres for intracameral or anterior vitreal placement include an anti-hypertensive agent and a biodegradable polymer effective to treat an ocular hypertensive condition (such as glaucoma) by relapsing therapeutic amount of the anti-hypertensive agent over a period of time between 10 days and 1 year.
98 Citations
18 Claims
- 1. A method for treating elevated intraocular pressure, the method comprising the step of intracameral or anterior vitreal administration, to a patient with elevated intraocular pressure (IOP), of a sustained release implant comprising an anti-hypertensive agent and a biodegradable polymer, wherein the implant comprises from about 10 to about 50 weight percent the anti-hypertensive agent and from about 50 to about 90 weight percent the biodegradable polymer, and wherein the implant releases therapeutically effective amounts of the anti-hypertensive for a period of time between about 10 days and about 120 days.
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3. A method for treating elevated intraocular pressure, the method comprising the step of intracameral administration against the trabecular meshwork, to a patient with elevated intraocular pressure, of a sustained release rod shaped implant comprising latanoprost or bimatoprost and a biodegradable polymer, wherein the implant comprises from about 10 to about 50 weight percent the latanoprost or bimatoprost and from about 50 to about 90 weight percent the biodegradable polymer, wherein the implant releases therapeutically effective amounts of the latanoprost or bimatoprost for a period of time between about 10 days and about 120 days.
- 4. A method for treating elevated intraocular pressure, the method comprising the step of intracameral or anterior vitreal administration to a patient with elevated intraocular pressure a plurality of sustained release biodegradable microspheres having an average diameter between 30 and 60 microns, the microspheres comprising from about 10 to about 30 weight percent an anti-hypertensive agent and from about 70 to about 90 weight percent a biodegradable polymer, wherein the microspheres release therapeutically effective amounts of the anti-hypertensive agent for a period of time between about 10 days and about 120 days.
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9. A method for treating elevated intraocular pressure, the method comprising the step of intracameral administration to a patient with elevated intraocular pressure a plurality of sustained release biodegradable microspheres having an average diameter between 30 and 60 microns, the microspheres comprising from about 10 to about 30 weight percent latanoprost and from about 70 to about 90 weight percent a biodegradable polymer, wherein the microspheres release therapeutically effective amounts of the latanoprost for a period of time between about 10 day and about 120 days.
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10. A method for treating elevated intraocular pressure, the method comprising the step of intracameral administration against the trabecular meshwork, to a patient with elevated intraocular pressure, a sustained release rod shaped implant comprising latanoprost and a biodegradable polymer, wherein the implant comprises from about 10 to about 50 weight percent an anti-hypertensive agent and from about 50 to about 90 weight percent a biodegradable polymer, wherein the implant releases therapeutically effective amounts of the latanoprost for a period of time between about 10 day and about 120 days.
- 11. A pharmaceutical composition for intraocular use to treat an ocular condition, the composition comprising a plurality of sustained release biodegradable microspheres having an average diameter between 30 and 60 microns, the microspheres comprising from about 10 to about 30 weight percent an anti-hypertensive agent and from about 70 to about 90 weight percent a biodegradable polymer, wherein the microspheres release therapeutically effective amounts of the anti-hypertensive agent for a period of time between about 10 day and about 120 days.
Specification