BIOSENSOR
First Claim
1. A biosensor comprising:
- a substrate having buried therein an electronic sensing element for sensing electrical variations due to a change in the status of a biomolecule, said substrate having a substrate surface located above the buried electronic sensing element;
a structured top layer covering the substrate surface, said structured top layer having a top surface located above the substrate surface, said top surface providing a sensing region on which a sample solution containing the biomolecule is placed,a sensing electrode electrically coupled to the electronic sensing element, said sensing electrode having at least a part of its surface exposed to the sensing region, andat least one channel for immobilizing the biomolecule via by suction through said channel, said channel being arranged in the structured top layer.
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Accused Products
Abstract
A biosensor which comprises a substrate (101) having a buried electronic sensing element and a substrate surface (124) above the buried electronic sensing element; a structured top layer (125) covering the substrate surface (124), having a top surface above the substrate surface (124), and comprising at least one stimulation and/or sensing electrode (116) and a channel (121) for holding the biomolecule by means of suction through said channel (121) arranged between the top surface (125) and the substrate surface (124), the sensing electrode (116) being electrically coupled to the electronic sensing element; wherein the top surface (125) is provided for placing a biomolecule present in a sample solution thereupon, the sensing electrode (116) is provided for sensing electrical variations in and presence of the biomolecule.
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Citations
59 Claims
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1. A biosensor comprising:
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a substrate having buried therein an electronic sensing element for sensing electrical variations due to a change in the status of a biomolecule, said substrate having a substrate surface located above the buried electronic sensing element; a structured top layer covering the substrate surface, said structured top layer having a top surface located above the substrate surface, said top surface providing a sensing region on which a sample solution containing the biomolecule is placed, a sensing electrode electrically coupled to the electronic sensing element, said sensing electrode having at least a part of its surface exposed to the sensing region, and at least one channel for immobilizing the biomolecule via by suction through said channel, said channel being arranged in the structured top layer. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59)
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25. A method of forming a biosensor comprising:
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providing a substrate having buried therein an electronic sensing element for sensing electrical variations due to a change in the status of a biomolecule, and a substrate surface located above the buried electronic sensing element; covering the substrate surface with a structured top layer having a top surface above the substrate surface; forming in or on the structured top layer a sensing electrode, the sensing electrode configured to sense electrical variations in the biomolecule; forming in or on the structured top layer at least one channel for immobilizing the biomolecule via suction; electrically coupling the sensing electrode to the electronic sensing element, adapting the top surface for placing a biomolecule present in a sample solution thereupon; and forming within the structured top layer at least one channel that is adapted to exert a suction force on the biomolecule. - View Dependent Claims (26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44)
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Specification