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METHODS AND KITS FOR IDENTIFICATION OF ANTI-EXCITOTOXIC COMPOUNDS

  • US 20100248986A1
  • Filed: 09/05/2008
  • Published: 09/30/2010
  • Est. Priority Date: 09/06/2007
  • Status: Abandoned Application
First Claim
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1. A method of identifying compounds reducing excitotoxicity in neurons, the method comprising:

  • a) providing a library of compounds suspected of reducing excitotoxicity in neurons;

    b) providing a plurality of samples of glial cells;

    c) contacting at least one member of the plurality of the samples with at least one member of the library of the compounds suspected of reducing excitotoxicity in neurons;

    d) determining the amount of EAAT-1 protein in said at least one member of the plurality of the samples of glial cells contacted with the at least one member of the library of the compounds suspected of reducing excitotoxicity in neurons;

    e) comparing the amount of the EAAT-1 protein from step (d) with the amount of EAAT protein from at least one member of the plurality of samples of glial cells not contacted with the at least one member of the library of the compounds suspected of reducing excitotoxicity in neurons; and

    f) selecting the members of the library of compounds suspected of reducing excitotoxicity in neurons which increase the amount of the EAAT protein in the respective members of the plurality of samples of glial cells.

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