METHODS OF TREATING SKIN WITH AROMATIC SKIN-ACTIVE INGREDIENTS

• US 20100249222A1
• Filed: 06/09/2010
• Published: 09/30/2010
• Est. Priority Date: 02/01/2008
• Status: Active Grant

• Current Assignee: Mary Kay Incorporated (Mary Kay Holding Corporation)
• Original Assignee: Mary Kay Incorporated (Mary Kay Holding Corporation)
• Inventors: Gomez, Cristi, Florence, Tiffany C., Hines, Michelle D., Walke, Bob
• Granted Patent: US 8,399,521 B2
• Time in Patent Office: Days
• US Class Current: 514/450
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 2800/522 Antioxidants; Radical scavengers
• CPC Class Codes: A61K 31/045 Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
• CPC Class Codes: A61K 31/35 having six-membered rings with one oxygen as the only ring hetero atom
• CPC Class Codes: A61K 31/365 Lactones
• CPC Class Codes: A61K 8/33 containing oxygen
• CPC Class Codes: A61K 8/34 Alcohols
• CPC Class Codes: A61K 8/342 Alcohols having more than seven atoms in an unbroken chain
• CPC Class Codes: A61K 8/35 Ketones, e.g. benzophenone
• CPC Class Codes: A61K 8/37 Esters of carboxylic acids
• CPC Class Codes: A61K 8/4973 with oxygen as the only hetero atom
• CPC Class Codes: A61K 8/498 having 6-membered rings or their condensed derivatives, e.g. coumarin
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: A61Q 19/00 Preparations for care of the skin

Abstract

A method for treating skin, reducing oxidative damage to a skin cell, reducing lipoxygenase (LO) activity in a skin cell, reducing cyclooxygenase (COX) activity in a skin cell, reducing tumor necrosis factor alpha (TNF-α) in a skin cell, or reduction matrix metalloproteinase enzyme activity in a skin cell comprising contacting skin or a skin cell with an aromatic skin-active ingredient.

Claims

1. A method of treating a skin condition comprising topically applying to skin in need thereof a composition comprising 4-methyl-3-decen-5-ol, 3,3-dimethyl-5(2,2,3-trimethyl-3-cyclopenten-1-yl)-4-penten-2-ol, a mixture comprising 1-(1,2,3,4,5,6,7,8-octahydro-2,3,8,8-tetramethyl-2-naphthalenyl)ethan-1-one, 1-(2,3,8,8-tetramethyl-1,2,3,5,6,7,8,8a-octahydronaphthalen-2-yl)ethanone, and 1-(2,3,8,8-tetramethyl-1,2,3,4,6,7,8,8a-octahydronaphthalen-2-yl)ethanone, 2,6-dimethyl-5-heptenal, 3-hexen-1-ol, or (3E)-4-(2,6,6-trimethylcyclohex-1-en-1-yl)but-3-en-2-one.

2. The method of claim 1, wherein the composition is applied to a fine line or wrinkle and reduces MMP-9 activity in a skin cell of the skin.

3. The method of claim 1, wherein the composition is applied to inflamed skin and reduces COX-2 activity or lipoxygenase activity in a skin cell of the skin.

4. The method of claim 1, wherein the composition comprises 4-methyl-3-decen-5-ol, 3,3-dimethyl-5(2,2,3-trimethyl-3-cyclopenten-1-yl)-4-penten-2-ol, a mixture comprising 1-(1,2,3,4,5,6,7,8-octahydro-2,3,8,8-tetramethyl-2-naphthalenyl)ethan-1-one, 1-(2,3,8,8-tetramethyl-1,2,3,5,6,7,8,8a-octahydronaphthalen-2-yl)ethanone, and 1-(2,3,8,8-tetramethyl-1,2,3,4,6,7,8,8a-octahydronaphthalen-2-yl)ethanone, 2,6-dimethyl-5-heptenal, 3-hexen-1-ol, and (3E)-4-(2,6,6-trimethylcyclohex-1-en-1-yl)but-3-en-2-one.

5. The method of claim 1, wherein the composition comprises 4-methyl-3-decen-5-ol.

6. The method of claim 1, wherein the composition comprises 3,3-dimethyl-5(2,2,3-trimethyl-3-cyclopenten-1-yl)-4-penten-2-ol.

7. The method of claim 1, wherein the composition comprises a mixture comprising 1-(1,2,3,4,5,6,7,8-octahydro-2,3,8,8-tetramethyl-2-naphthalenyl)ethan-1-one, 1-(2,3,8,8-tetramethyl-1,2,3,5,6,7,8,8a-octahydronaphthalen-2-yl)ethanone, and 1-(2,3,8,8-tetramethyl-1,2,3,4,6,7,8,8a-octahydronaphthalen-2-yl)ethanone.

8. The method of claim 1, wherein the composition comprises 2,6-dimethyl-5-heptenal.

9. The method of claim 1, wherein the composition comprises 3-hexen-1-ol.

10. The method of claim 1, wherein the composition comprises (3E)-4-(2,6,6-trimethylcyclohex-1-en-1-yl)but-3-en-2-one.

11. The method of claim 1, wherein the composition is an emulsion, a cream, or a lotion.

12. A method of treating a fine line or wrinkle comprising topically applying to a fine line or wrinkle on skin a composition comprising 3-hexen-1-ol, 4-methyl-3-decen-5-ol, or (3E)-4-(2,6,6-trimethylcyclohex-1-en-1-yl)but-3-en-2-one, wherein MMP-9 activity is reduced in a skin cell of the skin.

13. The method of claim 12, wherein the composition comprises 3-hexen-1-ol.

14. The method of claim 12, wherein the composition comprises 4-methyl-3-decen-5-ol.

15. The method of claim 12, wherein the composition comprises (3E)-4-(2,6,6-trimethylcyclohex-1-en-1-yl)but-3-en-2-one.

16. The method of claim 12, wherein the composition comprises 3-hexen-1-ol, 4-methyl-3-decen-5-ol, and (3E)-4-(2,6,6-trimethylcyclohex-1-en-1-yl)but-3-en-2-one, wherein MMP-9 activity is reduced in a skin cell of the skin.

17. A method of reducing skin inflammation comprising topically applying to inflamed skin a composition comprising 3-hexen-1-ol, 3,3-dimethyl-5 (2,2,3-trimethyl-3-cyclopenten-1-yl)-4-penten-2-ol, 2,6-dimethyl-5-heptenal, or a mixture comprising 1-(1,2,3,4,5,6,7,8-octahydro-2,3,8,8-tetramethyl-2-naphthalenyl)ethan-1-one, 1-(2,3,8,8-tetramethyl-1,2,3,5,6,7,8,8a-octahydronaphthalen-2-yl)ethanone, and 1-(2,3,8,8-tetramethyl-1,2,3,4,6,7,8,8a-octahydronaphthalen-2-yl)ethanone, wherein COX-2 activity or lipoxygenase activity is reduced in a skin cell of the skin.

18. The method of claim 17, wherein the composition comprises 3-hexen-1-ol.

19. The method of claim 17, wherein the composition comprises 3,3-dimethyl-5(2,2,3-trimethyl-3-cyclopenten-1-yl)-4-penten-2-ol.

20. The method of claim 17, wherein the composition comprises 2,6-dimethyl-5-heptenal.

21. The method of claim 17, wherein the composition comprises a mixture comprising 1-(1,2,3,4,5,6,7,8-octahydro-2,3,8,8-tetramethyl-2-naphthalenyl)ethan-1-one, 1-(2,3,8,8-tetramethyl-1,2,3,5,6,7,8,8a-octahydronaphthalen-2-yl)ethanone, and 1-(2,3,8,8-tetramethyl-1,2,3,4,6,7,8,8a-octahydronaphthalen-2-yl)ethanone.

22. The method of claim 17, wherein the composition comprises 3-hexen-1-ol, 3,3-dimethyl-5(2,2,3-trimethyl-3-cyclopenten-1-yl)-4-penten-2-ol, 2,6-dimethyl-5-heptenal, and a mixture comprising 1-(1,2,3,4,5,6,7,8-octahydro-2,3,8,8-tetramethyl-2-naphthalenyl)ethan-1-one, 1-(2,3,8,8-tetramethyl-1,2,3,5,6,7,8,8a-octahydronaphthalen-2-yl)ethanone, and 1-(2,3,8,8-tetramethyl-1,2,3,4,6,7,8,8a-octahydronaphthalen-2-yl)ethanone.