DEVICE AND METHOD FOR RESTORATION OF THE CONDITION OF BLOOD
First Claim
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1. Device for extracorporeal removal of harmful agents from blood or blood components, the device comprising full length heparin immobilized on a solid substrate by covalent end point attachment.
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Abstract
The present invention relates to a device for extracorporeal removal of harmful agents from blood or blood components, comprising full length heparin immobilized on a solid substrate by covalent end point attachment. The present invention also relates to a method for extracorporeal removal of a harmful agent from mammalian blood or blood components. The present invention further relates to a process for covalent end point attachment of full length heparin to a solid substrate.
33 Citations
41 Claims
- 1. Device for extracorporeal removal of harmful agents from blood or blood components, the device comprising full length heparin immobilized on a solid substrate by covalent end point attachment.
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20. Method for extracorporeal removal of a harmful agent from mammalian blood, comprising the steps:
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a) providing a sample of mammalian blood, b) bringing said sample into contact with full length heparin immobilized on a solid substrate by covalent end point attachment, under conditions allowing binding of said harmful agent to the heparin, c) separating the sample from the solid substrate, such that said harmful agent is at least partially retained on the solid substrate, and d) recovering said sample containing a reduced amount of said harmful agent. - View Dependent Claims (21)
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22. Method for treatment of a mammalian subject suffering from a condition caused or aggravated by a harmful agent, comprising the steps:
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a) extracting blood from the subject, b) bringing the extracted blood into contact with full length heparin immobilized on a solid substrate by covalent end point attachment, under conditions allowing binding of said harmful agent to the heparin, c) reintroducing the blood, containing a reduced amount of said harmful agent, into the bloodstream of the subject.
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- 23. Apparatus for extracorporeal circulation of blood or blood components, comprising a conventional extracorporeal blood treatment device and a device for removal of harmful agents.
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36. A process for covalent end point attachment of full length heparin to a solid substrate comprising the steps of:
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a) providing a solid substrate having primary amino functional groups, b) mixing said solid substrate of a) with full length heparin and a reducing agent in an aqueous medium, c) allowing the heparin to bind reductively to the amino functional groups, and d) recovering the solid substrate having covalently bound full length heparin on its surface. - View Dependent Claims (37, 38, 39, 40, 41)
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Specification