Reticulated elastomeric matrices, their manufacture and use in implantable devices
First Claim
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1. An implantable device comprising a reticulated resiliently-compressible elastomeric matrix.
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Abstract
This invention relates to biodurable, reticulated elastomeric matrices that are resiliently-compressible, their manufacture and uses including uses for implantable devices into or for topical treatment of patients, such as humans and other animals, for therapeutic, nutritional, or other useful purposes.
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Citations
49 Claims
- 1. An implantable device comprising a reticulated resiliently-compressible elastomeric matrix.
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14. A process for producing an elastomeric matrix comprising a polymeric material having a reticulated structure, the process comprising:
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a) fabricating a mold having surfaces defining a microstructural configuration for the elastomeric matrix; b) charging the mold with a flowable polymeric material; c) solidifying the polymeric material; and d) removing the mold to yield the elastomeric matrix. - View Dependent Claims (15, 16, 17, 18, 19, 20, 21)
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22. A process for producing an elastomeric matrix having a reticulated structure, the process comprising:
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a) coating a reticulated foam template with a flowable resistant material, optionally a thermoplastic polymer or a wax; b) exposing a coated surface of the foam template; c) removing the foam template to yield a casting of the reticulated foam template; d) coating the casting with an elastomer in a flowable state to form an elastomeric matrix; e) exposing a surface of the casting; and f) removing the casting to yield a reticulated elastomeric matrix comprising the elastomer. - View Dependent Claims (23)
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24. A lyophilization process for producing an elastomeric matrix having a reticulated structure, the process comprising:
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a) forming a solution comprising a solvent-soluble biodurable elastomer in a solvent; b) at least partially solidifying the solution to form a solid, optionally by cooling the solution; and c) removing the non-polymeric material, optionally by subliming the solvent from the solid under reduced pressure, to provide an at least partially reticulated elastomeric matrix comprising the elastomer. - View Dependent Claims (25)
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26. A polymerization process for preparing a reticulated elastomeric matrix, the process comprising admixing:
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a) a polyol component, b) an isocyanate component, c) a blowing agent, d) optionally, a crosslinking agent, e) optionally, a chain extender, f) optionally, at least one catalyst, g) optionally, a surfactant, and h) optionally, a viscosity modifier; to provide a crosslinked elastomeric matrix and reticulating the elastomeric matrix by a reticulation process to provide the reticulated elastomeric matrix. - View Dependent Claims (27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45)
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- 46. A process for preparing a reticulated composite elastomeric implantable device, the process comprising endoporously coating a reticulated elastomeric matrix with a coating material selected to encourage cellular ingrowth and proliferation.
Specification