Multizone Implants

• US 20100249944A1
• Filed: 03/11/2010
• Published: 09/30/2010
• Est. Priority Date: 03/31/2009
• Status: Abandoned Application

• Current Assignee: Covidien LP (Medtronic Plc)
• Original Assignee: Covidien LP (Medtronic Plc)
• Inventors: Stopek, Joshua, Thomas, Jonathan D.
• Application Number:
  US12/721,919
• Publication Number:
  US 20100249944A1
• Time in Patent Office: Days
• US Class Current: 623/23.570
• CPC Class Codes: A61B 17/0401 Suture anchors, buttons or pledgets, i.e. means for attaching sutures to bone, cartilage or soft tissue; Instruments for applying or removing suture anchors A61B17/0642 takes precedence; fixation devices for tendons or ligaments A61F2/0811
• CPC Class Codes: A61B 2017/00004 (bio)absorbable, (bio)resorbable, resorptive for implantable prostheses A61F2210/0004
• CPC Class Codes: A61B 2017/00893 pharmaceutically effective
• CPC Class Codes: A61B 2017/0445 cannulated, e.g. with a longitudinal through-hole for passage of an instrument
• CPC Class Codes: A61B 2017/045 snug fit within the anchor

Abstract

Medical devices having more than one degradation zone or degradation mechanism are used for orthopedic repair devices and soft tissue fixation devices.

Claims

1. An implant comprising at least two degradation zones having different degradation rates, the at least two degradation zones including a first degradation zone at a distal portion of the implant and a second degradation zone at a proximal portion of the implant.

2. The implant according to claim 1, further comprising a third degradation zone at an intermediate portion of the implant, the intermediate portion being located between the distal portion and the proximal portion of the implant.

3. The implant according to claim 1, wherein the first degradation zone has a faster degradation rate than the second degradation zone.

4. The implant according to claim 2, wherein the first degradation zone has a faster degradation rate than the third degradation zone and the third degradation zone has a faster degradation rate than the second degradation zone.

5. The implant according to claim 1, wherein the first degradation zone comprises a different composition than the second degradation zone.

6. The implant according to claim 1, wherein the first degradation zone comprises a composition that is the same as a composition of the second degradation zone.

7. The implant according to claim 1, further including an osteoconductive inorganic phase.

8. The implant according to claim 1, further comprising an interface between the first degradation zone and the second degradation zone.

9. The implant according to claim 2, further comprising an interface between at least one of the first and third degradation zones and the third and second degradation zones.

10. The implant according to claim 1, further comprising an interphase between the first degradation zone and the second degradation zone.

11. The implant according to claim 2, further comprising an interphase between at least one of the first and third degradation zones and the third and second degradation zones.

12. The implant according to claim 1, wherein the composite implant may be selected from the group consisting of orthopedic repair devices and soft tissue repair devices.

13. The implant according to claim 1, wherein the implant is a bone anchor.

14. The implant according to claim 1, wherein the degradation zones comprise materials selected from the group consisting of polyesters, polyester polyalkylene oxide copolymers, polyorthoesters, polyhydroxybutyrates, polyhydroxyalkanoates, polyanhydrides, polyamines, polycarbonates, copolymers and combinations thereof.

15. The implant according to claim 1, wherein at least one degradation zone comprises a porous structure.

16. The implant according to claim 1, wherein the first degradation zone comprises more amorphous regions than the second degradation zone.

17. The implant according to claim 1, wherein the second degradation zone comprises more crystalline regions than the first degradation zone.

18. The implant according to claim 1, further comprising a bioactive agent.

19. The implant according to claim 1, wherein at least one degradation zone comprises a polymer drug.

20. The implant according to claim 1, wherein the degradation rate of at least one degradation zone corresponds to an elution of a bioactive agent.